Masaomi Nangaku
University of Tokyo
Internal medicineEndocrinologyPathologyRenal functionHypoxia-inducible factorsIntensive care medicineChemistryImmunologyOxidative stressHemodialysisAnemiaKidney diseaseHypoxia (medical)KidneyAcute kidney injuryCancer researchNephrologyMedicineBiologyGastroenterologyCell biology
Publications 645
#1Akira Okada (UTokyo: University of Tokyo)H-Index: 6
#2Hayato Yamana (UTokyo: University of Tokyo)H-Index: 16
Last. Hideo Yasunaga (UTokyo: University of Tokyo)H-Index: 55
view all 11 authors...
Objectives null Renal failure and hepatic cirrhosis are mutually aggravating factors. However, no specific therapeutic strategies for hepatic encephalopathy (HE) and end-stage kidney disease have been established. The coexistence, with an extremely poor prognosis, makes randomized controlled trials unfeasible. We evaluated whether an infusion of branched-chain amino acids was associated with mortality in patients hospitalized for HE and end-stage kidney disease. null Design and Methods null Usin...
#1Yuki Kawai (UTokyo: University of Tokyo)
#2Akiko Sankoda (UTokyo: University of Tokyo)
Last. Nobuhito Hirawa (Yokohama City University Medical Center)H-Index: 25
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Background: Diabetic kidney disease (DKD) is one of the main complications of type 2 diabetes mellitus (T2DM). DKD is a known risk factor for end-stage renal disease, cardiovascular disease, and all-cause death. Effective intervention for early-stage DKD is vital to slowing down the progression of kidney disease and improve prognoses. Mobile health (mHealth) is reportedly effective in supporting patients’ self-care and improving glycemic control, but the impact of mHealth on DKD has yet to be sh...
#1Tadao Akizawa (Showa University)H-Index: 62
#2Masaomi Nangaku (UTokyo: University of Tokyo)H-Index: 80
Last. Hideki HirakataH-Index: 57
view all 7 authors...
Enarodustat (JTZ-951) is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor developed for treating anemia in chronic kidney disease. Two open-label, uncontrolled phase 3 studies evaluated the 52-week safety and efficacy of enarodustat in Japanese anemic patients with chronic kidney disease not on dialysis (n = 132) [SYMPHONY ND-Long study] or on maintenance hemodialysis (n = 136) [SYMPHONY HD-Long study]. The most frequent adverse events were viral upper respiratory tract infection (2...
#1H. Kato (UTokyo: University of Tokyo)
#2Naoko Hidaka (UTokyo: University of Tokyo)
Last. Nobuaki Ito (UTokyo: University of Tokyo)H-Index: 17
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INTRODUCTION This study assessed the performance of a new fully automated immunoassay for fibroblast growth factor (FGF) 23 (Determinar CL FGF23 CL) among healthy individuals and those with chronic hypophosphatemia compared with the previous assay (Kainos FGF23 KI). MATERIALS AND METHODS A total of 380 serum samples from healthy participants were collected to determine the reference range of FGF23 levels with CL. A total of 200 serum samples from 22 hypophosphatemic patients were collected simul...
#1Yuichiro Kitai (Kyoto University)H-Index: 4
#2Masaomi Nangaku (UTokyo: University of Tokyo)H-Index: 80
Last. Motoko Yanagita (Kyoto University)H-Index: 35
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Clinical Background: Older age has been associated with higher prevalence and progression of chronic kidney disease (CKD). The presence of CKD leads to an increased risk of end-stage renal disease, cardiovascular diseases, and death. Epidemiology: Progressive aging of the population is accompanied by an increase in the prevalence of CKD worldwide. The high prevalence of CKD in the aged population would result in a considerably greater social burden. Challenges: Structural and functional changes ...
#1Geraldo Silva Junior (University of Fortaleza)
#2Giovani Gadonski (PUCRS: Pontifícia Universidade Católica do Rio Grande do Sul)H-Index: 7
Last. Claudio Ronco (UNIPD: University of Padua)H-Index: 118
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The study of kidney diseases has been described since the Hippocratic era, but nephrology as a medical specialty dates from the mid-20th century. Despite all interesting aspects of nephrology, there is a lack of interest by young physicians for the specialty worldwide. Great discoveries have been made throughout the years, leading to great achievements in diagnosis, classification, and treatment of kidney diseases. There is a current interest in the search for novel biomarkers for early detectio...
#1Kayo Ikeda Kurakawa (UTokyo: University of Tokyo)H-Index: 1
#2Akira Okada (UTokyo: University of Tokyo)H-Index: 6
Last. Kiyohide Fushimi (Tokyo Medical and Dental University)H-Index: 58
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CONTEXT Insulinoma is the most common pancreatic functional neuroendocrine neoplasm, yet little information on recent clinical practice in patients with insulinoma, especially malignant insulinoma, is available. OBJECTIVE To clarify the characteristics and practice patterns in patients with insulinoma using a national inpatient database. METHODS Using the Japanese Diagnosis Procedure Combination database, we retrospectively identified patients with insulinoma admitted between 2010 and 2018. We c...
#1Rie Fujii (UTokyo: University of Tokyo)H-Index: 2
#2Sho Hasegawa (UTokyo: University of Tokyo)H-Index: 8
Last. Reiko Inagi (UTokyo: University of Tokyo)H-Index: 59
view all 9 authors...
The relevance of primary cilia shortening in kidney disease and its pathomechanism are largely unknown. Tubular damage in acute kidney injury (AKI) is strongly associated with mitochondrial dysfunction. Thus, we investigated the interaction between primary cilia and mitochondria in cisplatin-induced AKI mouse models. We observed that the expression of intraflagellar transport 88 (IFT88), a ciliary maintenance protein, was decreased in the renal cortex following tubular damage due to cisplatin-in...
1 CitationsSource
#1Rikako Oki (UTokyo: University of Tokyo)H-Index: 1
#2Yosuke Hirakawa (UTokyo: University of Tokyo)H-Index: 9
Last. Masaomi Nangaku (UTokyo: University of Tokyo)H-Index: 80
view all 10 authors...
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) had clinical success in the treatment of non-small cell lung carcinoma (NSCLC). An effect of this drug on kidney has not been clarified and the occurrence of glomerulonephritis related to EGFR-TKI has rarely been reported. We present the case of a 71-year-old man with NSCLC who developed proteinuria and microscopic hematuria with the rise in a titer of MPO-ANCA, when 2 years and 3 months passed since the initiation of erloti...
#1Ryo Matsuura (UTokyo: University of Tokyo)H-Index: 6
#2Tetsushi Yamashita (UTokyo: University of Tokyo)H-Index: 5
Last. Kent Doi (UTokyo: University of Tokyo)H-Index: 38
view all 9 authors...
Although chronic heart failure is clinically associated with acute kidney injury (AKI), the precise mechanism that connects kidney and heart remains unknown. Here, we elucidate the effect of pre-existing heart failure with reduced ejection fraction (HFrEF) on kidney via sympathetic activity, using the combining models of transverse aortic constriction (TAC) and unilateral renal ischemia reperfusion (IR). The evaluation of acute (24 h) and chronic (2 weeks) phases of renal injury following IR 8 w...