Gabriele Capurso
Vita-Salute San Raffaele University
CancerInternal medicineRadiologySurgeryPathologyOncologySingle-nucleotide polymorphismProspective cohort studyPancreatitisAcute pancreatitisPancreatic diseasePancreasDiseasePancreatic cancerIn patientCancer researchMedicineBiologyGastroenterologyMeta-analysis
Publications 378
#1Patrick MichlH-Index: 15
#2Matthias Löhr (Karolinska University Hospital)H-Index: 55
Last. Luigi Ricciardiello (UNIBO: University of Bologna)H-Index: 35
view all 0 authors...
BACKGROUND Pancreatic ductal adenocarcinoma is the deadliest cancer worldwide with a 98% loss-of-life expectancy and a 30% increase in the disability-adjusted life years during the last decade in Europe. The disease cannot be effectively prevented nor being early detected. When diagnosed, 80% of patients have tumors that are in incurable stages, while for those who undergo surgery, 80% of patients will present with local or distant metastasis. Importantly, chemotherapies are far from being effec...
#1Marco Lanzillotta (UniSR: Vita-Salute San Raffaele University)H-Index: 16
#2Emanuel Della-Torre (UniSR: Vita-Salute San Raffaele University)H-Index: 27
Last. Gabriele Capurso (UniSR: Vita-Salute San Raffaele University)H-Index: 56
view all 10 authors...
Abstract null null Background null Type I autoimmune pancreatitis (AIP) and IgG4-related sclerosing cholangitis (IgG4-SC) belong to the IgG4-related disease (IgG4-RD) spectrum. Both entities respond to glucocorticoids, but iatrogenic toxicity associated with prolonged steroid therapy and relapse represent relevant clinical concerns in the long-term. Rituximab is increasingly used as an effective alternative strategy to induce remission but data regarding the safety and efficacy of B-cell depleti...
#1Laura Pistoni (UniPi: University of Pisa)H-Index: 1
#2Manuel Gentiluomo (UniPi: University of Pisa)H-Index: 6
Last. Yogesh K. Vashist (UHH: University of Hamburg)H-Index: 27
view all 58 authors...
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers. Its poor prognosis is predominantly due to the fact that most patients remain asymptomatic until the disease reaches an advanced stage, alongside the lack of early markers and screening strategies. A better understanding of PDAC risk factors is essential for the identification of groups at high risk in the population. Genome-wide association studies (GWAS) have been a powerful tool for detecting genetic variants associated...
#1Piera Zaccari (UniSR: Vita-Salute San Raffaele University)
#2Matteo TacelliH-Index: 5
Last. Paolo Giorgio ArcidiaconoH-Index: 40
view all 5 authors...
#1Gianpaolo BalzanoH-Index: 44
#2Giovanni Guarneri (UniSR: Vita-Salute San Raffaele University)H-Index: 4
Last. Massimo Falconi (UniSR: Vita-Salute San Raffaele University)H-Index: 105
view all 6 authors...
Abstract Background Adequate criteria for pancreatic surgery centralization are debated. This retrospective study aimed to define a reproducible method for complex care centralization, accounting for hospital performance and access to care. Methods The method consisted in: 1. Analysis of overall outcome and mortality-related factors. 2. Assessment of volume and adjusted mortality of each hospital. 3. Definition of different centralization models. 4. Final adjustments to guarantee access to care,...
#2Manuel Gentiluomo (UniPi: University of Pisa)H-Index: 6
Last. Daniele Campa (UniPi: University of Pisa)H-Index: 34
view all 66 authors...
Background Most cases of pancreatic ductal adenocarcinoma (PDAC) are asymptomatic in early stages, and the disease is typically diagnosed in advanced phases, resulting in very high mortality. Tools to identify individuals at high risk of developing PDAC would be useful to improve chances of early detection. Objective We generated a polygenic risk score (PRS) for PDAC risk prediction, combining the effect of known risk SNPs, and carried out an exploratory analysis of a multifactorial score. Metho...
5 CitationsSource
#1Laura Apadula (UniSR: Vita-Salute San Raffaele University)H-Index: 1
#2Gabriele CapursoH-Index: 56
Last. Paolo Giorgio ArcidiaconoH-Index: 40
view all 3 authors...
OBJECTIVE Increasing attention is paid to measure patient's experience using specific patient-reported experience measures (PREMs) as tool to assess the overall quality of care provided. The European Society of Gastrointestinal Endoscopy and the United European Gastroenterology have recognized the measure of quality of endoscopy facilities as a priority to provide an adequate service. However, although some studies included patient satisfaction measurement, specific PREMs for gastrointestinal en...
#1Emanuel Della-Torre (UniSR: Vita-Salute San Raffaele University)H-Index: 27
#2Marco Lanzillotta (UniSR: Vita-Salute San Raffaele University)H-Index: 16
Last. Lorenzo Dagna (UniSR: Vita-Salute San Raffaele University)H-Index: 37
view all 8 authors...
ABSTRACT Background The 2019 ACR/EULAR Classification Criteria for IgG4-related disease (IgG4-RD) represent a fundamental tool for patient enrollment in research studies and in clinical trials but their usefulness in daily clinical practice remains unknown. Objective To validate the 2019 ACR/EULAR Classification Criteria for IgG4-RD in a real-life setting and to anticipate their utility for orienting disease diagnosis and patient management. Methods Four experts were asked to classify 200 patien...