Ole Mors
Aarhus University Hospital
GeneGenome-wide association studyPsychiatryInternal medicineSingle-nucleotide polymorphismPsychologyDanishGenetic associationCohort studyBipolar disorderDepression (differential diagnoses)AntidepressantMajor depressive disorderPopulationGeneticsClinical psychologyMedicineCohortSchizophreniaBiology
Publications 628
#1Veera M. Rajagopal (Lundbeck)H-Index: 10
#2Jinjie Duan (Lundbeck)
Last. Marie Bækvad-Hansen (AU: Aarhus University)H-Index: 13
view all 22 authors...
Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder, with onset in childhood ("childhood ADHD"), and around two thirds of affected individuals will continue to have ADHD symptoms in adulthood ("persistent ADHD"). Age at first diagnosis can vary, and sometimes ADHD is first diagnosed in adulthood ("late-diagnosed ADHD"). null In this study, we analyzed a large Danish population-based case-cohort generated by iPSYCH in order to identify common genetic risk loci and per...
#1Sonja LaBianca (Lundbeck)H-Index: 1
Last. Vivek Appadurai (Lundbeck)H-Index: 11
view all 27 authors...
Abstract null Attention deficit hyperactivity disorder (ADHD) is a complex disorder with heterogeneous clinical presentations that manifest variability in long-term outcomes. The genetic contributions to this clinical heterogeneity, however, are not well understood. Here, we study 14 084 individuals diagnosed with ADHD to identify several genetic factors underlying clinical heterogeneity. One genome-wide significant locus was specifically associated with an autism spectrum disorder (ASD) diagnos...
#1Tine Holm (Aarhus University Hospital)H-Index: 6
#2Ole Mors (Aarhus University Hospital)H-Index: 88
AIM While it is known that being mechanically restrained during hospitalization can, in severe cases, lead to PTSD in individuals with mental illness, less is known about why some develop posttraumatic stress reactions following restraint while others do not. This study examined whether the amount of exposure to mechanical restraint and patients' interpretations of the episodes' centrality to their identity were related to symptoms of PTSD in individuals with schizophrenia. METHODS We asked 20 i...
#1Arndis Simonsen (Aarhus University Hospital)H-Index: 8
#2Riccardo Fusaroli (AU: Aarhus University)
Last. Daniel Campbell-Meiklejohn (University of Sussex)H-Index: 14
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An abnormality in inference, resulting in distorted internal models of the world, has been argued to be a common mechanism underlying the heterogeneous psychopathology in schizophrenia. However, findings have been mixed as to wherein the abnormality lies and have typically failed to find convincing relations to symptoms. The limited and inconsistent findings may have been due to methodological limitations of the experimental design, such as conflating other factors (e.g. comprehension) with the ...
1 CitationsSource
#1Isabell Brikell (Lundbeck)H-Index: 13
#2Theresa Wimberley (AU: Aarhus University)H-Index: 15
Last. Søren DalsgaardH-Index: 35
view all 16 authors...
Objective: Stimulant medications are effective for treating attention deficit hyperactivity disorder (ADHD), yet discontinuation and switch to nonstimulant ADHD medications are common. This study a...
#1Veerle PaternosterH-Index: 4
#2Anders Valdemar Edhager (Aarhus University Hospital)H-Index: 4
Last. Jane H. Christensen (Lundbeck)H-Index: 21
view all 11 authors...
Genetic studies have repeatedly shown that the Bromodomain containing 1 gene, BRD1, is involved in determining mental health, and the importance of the BRD1 protein for normal brain function has been studied in both cell models and constitutive haploinsufficient Brd1+/- mice. Homozygosity for inactivated Brd1 alleles is lethal during embryonic development in mice. In order to further characterize the molecular functions of BRD1 in the brain, we have developed a novel Brd1 knockout mouse model (B...
#1Xueping Liu (Centre for Mental Health)H-Index: 6
#1Xueping Liu (Centre for Mental Health)H-Index: 1
Last. Michael E. Benros (Centre for Mental Health)H-Index: 32
view all 15 authors...
1 CitationsSource
#1Strom Ni (Humboldt University of Berlin)
#2Jakob Grove (AU: Aarhus University)H-Index: 51
Last. Mattheisen M (Dal: Dalhousie University)H-Index: 1
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Among patients with obsessive-compulsive disorder (OCD), 65-85% manifest another psychiatric disorder concomitantly or at some other time point during their life. OCD is highly heritable, as are many of its comorbidities. A possible genetic heterogeneity of OCD in relation to its comorbid conditions, however, has not yet been exhaustively explored. We used a framework of different approaches to study the genetic relationship of OCD with three commonly observed comorbidities, namely major depress...
#1Mattheisen M (Dal: Dalhousie University)H-Index: 1
#1Manuel Mattheisen (Dal: Dalhousie University)
Last. Anders D. Børglum (AU: Aarhus University)H-Index: 67
view all 33 authors...
Attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are highly heritable neurodevelopmental disorders with a considerable overlap in their genetic etiology. We dissected their shared and distinct genetic architecture by cross-disorder analyses of large data sets, including samples with information on comorbid diagnoses. We identified seven loci shared by the disorders and the first five genome-wide significant loci differentiating the disorders. All five differenti...