Brigitte Wildemann
University Hospital Heidelberg
Internal medicinePathologyMagnetic resonance imagingAquaporin 4AntibodyAutoantibodyNeurologyPediatricsImmunologyOptic neuritisTransverse myelitisMyelitisDiseaseCerebrospinal fluidMultiple sclerosisNeuromyelitis opticaGynecologyMedicineBiologyGastroenterology
Publications 315
#1Brigitte Wildemann (Heidelberg University)H-Index: 63
#2Sven Jarius (Heidelberg University)H-Index: 65
Last. Andrea Viehöver (Heidelberg University)H-Index: 3
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#1Antonios Bayas (Augsburg College)H-Index: 19
#2Achim Berthele (TUM: Technische Universität München)H-Index: 48
Last. Brigitte Wildemann (University Hospital Heidelberg)H-Index: 63
view all 5 authors...
1 CitationsSource
#1Manfred WickH-Index: 16
#2Catharina C. Gross (WWU: University of Münster)H-Index: 31
Last. Martin StangelH-Index: 63
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The analysis of cells in the cerebrospinal fluid (CSF) is a routine procedure that is usually performed manually using the Fuchs–Rosenthal chamber and cell microscopy for cell counting and differentiation. In order to reduce the requirement for manual assessment, automated analyses by devices mainly used for blood cell analysis have been also used for CSF samples. Here, we summarize the current state of investigations using these automated devices and critically review their limitations. Despite...
#1Susanna Asseyer (Humboldt University of Berlin)H-Index: 9
#2Eugenia Henke (RUB: Ruhr University Bochum)H-Index: 1
Last. Ilya Ayzenberg (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 19
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BACKGROUND AND PURPOSE Myelin oligodendrocyte glycoprotein-antibody (MOG-ab)-associated disease (MOGAD) is an inflammatory autoimmune condition of the CNS. However, data on pain and depression have remained scarce. The aim of this study was to assess features of chronic pain and depression as well as their impact on health-related quality of life (hr-QoL) in MOGAD. METHODS Patients with MOGAD were identified in the Neuromyelitis Optica Study Group (NEMOS) registry. Data were acquired by a questi...
2 CitationsSource
#1Dominic Schmid (DKFZ: German Cancer Research Center)H-Index: 1
#2Uwe Warnken (DKFZ: German Cancer Research Center)H-Index: 20
Last. Tobias Kessler (DKFZ: German Cancer Research Center)H-Index: 10
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Recent technological advances in molecular diagnostics through liquid biopsies hold the promise to repetitively monitor tumor evolution and treatment response of brain malignancies without the need of invasive surgical tissue accrual. Here, we implemented a mass spectrometry-based protein analysis pipeline which identified hundreds of proteins in 251 cerebrospinal fluid (CSF) samples from patients with four types of brain malignancies (glioblastoma, lymphoma, brain metastasis and leptomeningeal ...
#1Sven Jarius (University Hospital Heidelberg)H-Index: 65
#2Brigitte Wildemann (University Hospital Heidelberg)H-Index: 63
Die Aquaporin-4(AQP4)-Immunglobulin-G(IgG)-assoziierte Neuromyelitis-optica-Spektrum-Erkrankungen („neuromyelitis optica spectrum disorders“, NMOSD) und die Myelinoligodendrozytenglykoprotein(MOG)-IgG-assoziierte Enzephalomyelitis (MOG-EM) sind wichtige autoimmune Differenzialdiagnosen der Multiplen Sklerose und unterscheiden sich von dieser u. a. im Hinblick auf Therapie und Prognose. Die AQP4-IgG-positive NMOSD verlauft fast immer, die MOG-EM in mindestens 80 % der adulten Falle relapsierend. ...
1 CitationsSource
#1Sven Jarius (Heidelberg University)H-Index: 65
Last. Brigitte Wildemann (Heidelberg University)H-Index: 63
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BACKGROUND A positive MRZ reaction, as defined by intrathecal IgG production against at least two of its constituents, measles virus (M), rubella virus (R) and varicella zoster virus (Z), is detectable in ~ 63% of patients with multiple sclerosis (MS) and is currently considered the laboratory marker with the highest specificity and positive likelihood ratio for MS. However, M, R and Z are only the most well-established constituents of a broader intrathecal humoral immune response in MS. OBJECTI...
#1Steffen PfeufferH-Index: 10
#2Tobias Ruck (WWU: University of Münster)H-Index: 22
Last. Heinz WiendlH-Index: 86
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OBJECTIVES Alemtuzumab is effective in patients with active multiple sclerosis but has a complex safety profile, including the development of secondary autoimmunity. Most of patients enrolled in randomised clinical trials with alemtuzumab were either treatment naive or pretreated with injectable substances. Other previous disease-modifying treatments (DMTs) were not used in the study cohorts, and therefore, associated risks might yet remain unidentified. METHODS We retrospectively evaluated a pr...
5 CitationsSource
#1Jürgen HaasH-Index: 29
#2Henriette Rudolph (Heidelberg University)H-Index: 8
Last. Brigitte WildemannH-Index: 63
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The role of B cells in multiple sclerosis (MS) is increasingly recognized. B cells undergo compartmentalized redistribution in blood and cerebrospinal fluid (CSF) during active MS, whereby memory B cells accumulate in the CSF. While B-cell trafficking across the blood–brain barrier has been intensely investigated, cellular diapedesis through the blood–CSF barrier (BCSFB) is incompletely understood. To investigate how B cells interact with the choroid plexus to transmigrate into the CSF we isolat...
1 CitationsSource
#1Patrick Ostkamp (WWU: University of Münster)H-Index: 2
#2Anke Salmen (University of Bern)H-Index: 14
Last. Nicholas Schwab (WWU: University of Münster)H-Index: 23
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Multiple sclerosis (MS) disease risk is associated with reduced sun-exposure. This study assessed the relationship between measures of sun exposure (vitamin D [vitD], latitude) and MS severity in the setting of two multicenter cohort studies (n NationMS = 946, n BIONAT = 990). Additionally, effect-modification by medication and photosensitivity-associated MC1R variants was assessed. High serum vitD was associated with a reduced MS severity score (MSSS), reduced risk for relapses, and lower disab...
5 CitationsSource