Jaakko Tuomilehto
National Institute for Health and Welfare
EpidemiologyInternal medicineEndocrinologySurgeryDemographyPhysical therapyType 2 diabetesDiseaseBody mass indexImpaired glucose tolerancePopulationIncidence (epidemiology)Risk factorObesityGeneticsDiabetes mellitusMedicineGerontologyBlood pressureBiology
Publications 1310
#1Bin ZhouH-Index: 26
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Summary null null Background null Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. null null null Methods null We used data from 1990 to 2019 on people aged 30–79 years from population-representative studies with measurement of blood pressure and data on blood pressu...
#1Sina KavalakattH-Index: 11
#2Abdelkrim KhadirH-Index: 12
Last. Ali TissH-Index: 20
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The neuropeptide urocortin 3 (UCN3) has a beneficial effect on metabolic disorders, such as obesity, diabetes, and cardiovascular disease. It has been reported that UCN3 regulates insulin secretion and is dysregulated with increasing severity of obesity and diabetes. However, its function in the adipose tissue is unclear. We investigated the overexpression of UCN3 in 3T3-L1 preadipocytes and differentiated adipocytes and its effects on heat shock response, ER stress, inflammatory markers, and gl...
#1Rafael Gabriel (ISCIII: Carlos III Health Institute)H-Index: 5
#2Tania Acosta (Universidad del Norte, Colombia)H-Index: 5
Last. Jaakko TuomilehtoH-Index: 217
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Abstract null null Aims null /hypothesis. null To determine the best cut-off threshold value of the Finnish Diabetes Risk Score (FINDRISC) for the detection of diabetes and non-diabetic hyperglycaemia in people 35 years or older at primary health care settings in Europe. null null null Methods null Cross-sectional study in 11,444 adults from primary health care centres using community and opportunistic screening approaches. All participants completed the FINDRISC questionnaire and underwent a 2-...
#1Amanda I AdlerH-Index: 32
#2Peter H. Bennett (NIH: National Institutes of Health)H-Index: 101
Last. Nigel Unwin (UWI: University of the West Indies)H-Index: 73
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Abstract null null Executive Summary null This document updates the 1999 World Health Organization (WHO) classification of diabetes. It prioritizes clinical care and guides health professionals in choosing appropriate treatments at the time of diabetes diagnosis, and provides practical guidance to clinicians in assigning a type of diabetes to individuals at the time of diagnosis. It is a compromise between clinical and aetiological classification because there remain gaps in knowledge of the aet...
#1Soo Lim (Seoul National University Bundang Hospital)H-Index: 64
#2Alice Pik-Shan Kong (CUHK: The Chinese University of Hong Kong)
Last. Jaakko Tuomilehto (National Institute for Health and Welfare)H-Index: 217
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Abstract null null Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has changed the lives of many people across the globe. In addition to the effect of the virus on the biological functions in those infected individuals, many countries have launched government policy with additional impact of these quarantine procedures on the metabolic health of many people worldwide. This mini-review aimed to highlight current evidence regarding the in...
#1Ruth Stephen (University of Eastern Finland)H-Index: 4
#2Tiia Ngandu (National Institute for Health and Welfare)H-Index: 28
Last. Alina Solomon (KI: Karolinska Institutet)H-Index: 41
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The CAIDE (Cardiovascular Risk Factors, Aging and Dementia) Risk Score is a validated tool estimating dementia risk. It was previously associated with imaging biomarkers. However, associations between dementia risk scores (including CAIDE) and dementia-related biomarkers have not been studied in the context of an intervention. This study investigated associations between change in CAIDE score and change in neuroimaging biomarkers (brain magnetic resonance imaging (MRI) and Pittsburgh Compound B-...
#1Janika Nättinen (UTA: University of Tampere)H-Index: 9
#2Ulla Aapola (UTA: University of Tampere)H-Index: 11
Last. Hannu Uusitalo (UTA: University of Tampere)H-Index: 40
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#1Julia K. Goodrich (Broad Institute)H-Index: 24
#1Julia K. Goodrich (Broad Institute)H-Index: 2
Hundreds of thousands of genetic variants have been reported to cause severe monogenic diseases, but the probability that a variant carrier develops the disease (termed penetrance) is unknown for virtually all of them. Additionally, the clinical utility of common polygenetic variation remains uncertain. Using exome sequencing from 77,184 adult individuals (38,618 multi-ancestral individuals from a type 2 diabetes case-control study and 38,566 participants from the UK Biobank, for whom genotype a...
#1Zumin Shi (College of Health Sciences, Bahrain)H-Index: 37
#2Jaakko Tuomilehto (UH: University of Helsinki)H-Index: 217
Last. Paul Zimmet (Monash University)H-Index: 143
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BACKGROUND To compare the predictive value of the circadian syndrome (CircS) and Metabolic syndrome (MetS) for cardiovascular disease. METHOD We used the data of 9360 Chinese adults aged ≥40 years from the 2011 China Health and Retirement Longitudinal Study (CHARLS). Of the participants, 8253 people were followed in the 2015 survey. MetS was defined using the harmonized criteria. CircS was based on the components of the International Diabetes Federation (IDF) MetS plus short sleep and depression...
3 CitationsSource
BACKGROUND Evidence for the effects of exercise and dietary interventions on cognition from long-term randomized controlled trials (RCTs) in large general populations remains insufficient. OBJECTIVE The objective of our study was to investigate the independent and combined effects of resistance and aerobic exercise and dietary interventions on cognition in a population sample of middle-aged and older individuals. METHODS We conducted a 4-y RCT in 1401 men and women aged 57-78 y at baseline. The ...
1 CitationsSource