Donald R. Gerecke
Rutgers University
GeneMatrix metalloproteinaseDownregulation and upregulationPathologyMolecular biologyChemistryImmunologyBasement membraneInflammationNitrogen mustardLamininWound healingSulfur mustardMouse skinCancer researchBiochemistryMedicineBiologyCell biologyPharmacology
86Publications
18H-index
1,215Citations
Publications 86
Newest
#1Marion K. Gordon (RU: Rutgers University)H-Index: 21
#2Rita Hahn (RU: Rutgers University)H-Index: 3
Last. Donald R. Gerecke (RU: Rutgers University)H-Index: 18
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#1Diane E. Heck (RU: Rutgers University)H-Index: 2
#1Diane E. Heck (RU: Rutgers University)H-Index: 38
Last. Jeffrey D. Laskin (UMDNJ: University of Medicine and Dentistry of New Jersey)H-Index: 69
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Ultraviolet light radiation in sunlight is known to cause major alterations in growth and differentiation patterns of exposed human tissues. The specific effects depend on the wavelengths and doses of the light, and the nature of the exposed tissue. Both growth inhibition and proliferation are observed, as well as inflammation and immune suppression. Whereas in the clinical setting, these responses may be beneficial, for example, in the treatment of psoriasis and atopic dermatitis, as an environ...
102 CitationsSource
#1Donald R. Gerecke (RU: Rutgers University)H-Index: 18
#2Xianmin MengH-Index: 3
Last. David E. Birk (Thomas Jefferson University)H-Index: 78
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Source
#1Donald R. GereckeH-Index: 18
#2Pinaki BhattH-Index: 3
Last. Michael P. ShakarjianH-Index: 12
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Epidermolysis bullosa (EB), a genetic skin disease characterized by skin blistering, may be caused by mutations in any of a variety of genes that encode proteins required for maintaining the structural integrity of skin. Three of these genes, laminin-α3, laminin-β3, and laminin-γ2 produce separate polypeptides that together form the basement membrane protein, laminin 5. Disruption of laminin 5 protein causes skin blisters that may be further enhanced by the actions of matrix metalloproteinases (...
#1Donald R. Gerecke (RU: Rutgers University)H-Index: 18
Source
#1Eleni G. Tzortzaki (RU: Rutgers University)H-Index: 4
#2Jay A. Tischfield (RU: Rutgers University)H-Index: 81
Last. Donald R. Gerecke (RU: Rutgers University)H-Index: 18
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Collagens XII and XIV are members of a subfamily of fibril-associated collagens with interrupted triple-helices (FACITs) that facilitate the interactions of adjacent collagen fibrils. Using immunohistochemistry and in situ hybridization, we analyzed the spatial and temporal expression pattern of collagens XII and XIV during bleomycin-induced pulmonary fibrosis. C57Bl mice were treated with bleomycin (1 U, i.p., every other day for 8 days) or saline (control), and lung tissue samples were analyze...
24 CitationsSource
#1Manuel Koch (Cornell University)H-Index: 42
#2Friedrich Laub (Cornell University)H-Index: 14
Last. Marion K. Gordon (Cornell University)H-Index: 1
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Abstract Tissue-specific assembly of fibers composed of the major collagen types I and II depends in part on the formation of heterotypic fibrils, using the quantitatively minor collagens V and XI. Here we report the identification of a new fibrillar-like collagen chain that is related to the fibrillar α1(V), α1(XI), and α2(XI) collagen polypeptides and which is coexpressed with type I collagen in the developing bone and eye. The new collagen was designated the α1(XXIV) chain and consists of a l...
96 CitationsSource
#1Donald R. Gerecke (RU: Rutgers University)H-Index: 18
#2Xianmin Meng (Thomas Jefferson University)H-Index: 4
Last. David E. Birk (Thomas Jefferson University)H-Index: 78
view all 4 authors...
Abstract The entire mouse cDNA sequence for type XIV collagen was determined using overlapping PCR products. The 6456 nucleotide (nt) cDNA sequence contains a 5391-nt open reading frame encoding 1797 amino acid residues. The amino terminus has a 28-residue signal peptide that is followed by the mature polypeptide of 1769 amino acid residues with a calculated molecular mass of 193.2 kDa. The mouse α1(XIV) collagen chain is predicted to contain all the structural domains described for the polypept...
16 CitationsSource
#1Marion K. Gordon (RU: Rutgers University)H-Index: 21
#2Peihong Zhou (RU: Rutgers University)H-Index: 9
Last. Jeffrey D. Laskin (RU: Rutgers University)H-Index: 69
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#2Peihong ZhouH-Index: 9
Last. Smulian Md, Mph, John CH-Index: 2
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