Michael Sturek
Indiana University
AnatomyInternal medicineEndocrinologyBiomedical engineeringCardiologyChemistryMaterials scienceCoronary circulationArteryInsulin resistanceCoronary artery diseaseCoronary arteriesVascular smooth muscleMetabolic syndromeSmooth muscleMiniature swineCalciumDiabetes mellitusMedicineBiology
Publications 309
#1Jill K. Badin (IU: Indiana University)H-Index: 3
#2Caleb Eggenberger (Marian University)H-Index: 1
Last. Michael Sturek (IU: Indiana University)H-Index: 62
view all 8 authors...
Intracellular free Ca2+ ([Ca2+]i) dysregulation occurs in coronary smooth muscle (CSM) in atherosclerotic coronary artery disease (CAD) of metabolic syndrome (MetS) swine. Our goal was to determine how CAD severity, arterial structure, and MetS risk factors associate with [Ca2+]i dysregulation in human CAD compared to changes in Ossabaw miniature swine. CSM cells were dispersed from coronary arteries of explanted hearts from transplant recipients and from lean and MetS swine with CAD. CSM [Ca2+]...
#7Mitchel R. Stacy (OSU: Ohio State University)H-Index: 2
#1Poul Flemming Høilund-Carlsen (OUH: Odense University Hospital)H-Index: 36
#2Reza Piri (OUH: Odense University Hospital)H-Index: 10
Last. Oke Gerke (OUH: Odense University Hospital)H-Index: 25
view all 8 authors...
The evidence on atherosclerosis imaging with 18F-sodium-fluoride (NaF) positron emission tomography (PET) is hotly debated because of the different patient characteristics, methodology, vascular beds, etc. in reported studies. This review is a continuation of a previous review on this topic, which covered the period 2010-2018. The purpose was to examine whether some of the most important questions that the previous review had left open had been elucidated by the most recent literature. Using pri...
3 CitationsSource
#1Peter M. H. Heegaard (DTU: Technical University of Denmark)H-Index: 46
#2Michael Sturek (IU: Indiana University)H-Index: 62
Last. Graham J. Belsham (UCPH: University of Copenhagen)H-Index: 65
view all 4 authors...
The ongoing COVID-19 pandemic caused by infection with SARS-CoV-2 has created an urgent need for animal models to enable study of basic infection and disease mechanisms and for development of vaccines, therapeutics, and diagnostics. Most research on animal models for COVID-19 has been directed toward rodents, transgenic rodents, and non-human primates. The primary focus has been on the angiotensin-converting enzyme 2 (ACE2), which is a host cell receptor for SARS-CoV-2. Among investigated specie...
5 CitationsSource
#1Charles R. PowellH-Index: 9
#2Albert Kim (University College of Engineering)H-Index: 9
Last. Michael SturekH-Index: 62
view all 8 authors...
Metabolic Syndrome (MetS) has detrimental effects on the bladder, including detrusor underactivity. The progression and mechanism of disease are poorly understood. A swine model for diabetic bladder dysfunction (DBD) was established because of the pig's human-sized bladder and its ability to develop MetS by dietary modification alone. The hypothesis of this study is that this swine model will demonstrate oxidative stress associated with MetS, which contributes to both bladder fibrosis and detrus...
#1Yingchun CaoH-Index: 13
#2Mouhamad Alloosh (IU: Indiana University)H-Index: 16
Last. Ji-Xin ChengH-Index: 83
view all 4 authors...
#1Poul Flemming Høilund-Carlsen (University of Southern Denmark)H-Index: 36
#2Michael Sturek (IU: Indiana University)H-Index: 62
Last. Oke Gerke (University of Southern Denmark)H-Index: 25
view all 4 authors...
Purpose We examined the literature to elucidate the role of 18F-sodium fluoride (NaF)-PET in atherosclerosis.
17 CitationsSource
#1Austin J Borja (UPenn: University of Pennsylvania)H-Index: 6
#2Esha Kothekar (HUP: Hospital of the University of Pennsylvania)H-Index: 6
Last. Mona-Elisabeth Revheim (University of Oslo)H-Index: 12
view all 14 authors...
1609 Objectives: To quantify the effects of obesity and high-calcium diet on aortic calcification, assessed by 1) NaF-PET/CT and 2) number of aortic calcium depositions on histological section. Methods: This study included 13 swine divided into 4 groups: 2 animals on normal-calorie / normal-calcium diet (control), 4 metabolic syndrome (obese) pigs on high-calorie / normal-calcium diet (MetS), 3 MetS pigs on high-calorie / high-calcium supplement diet (HS), and 4 MetS pigs on high-calorie / high-...