María Elena Romero-Espejel
Universidad Autónoma de la Ciudad de México
SiderophoreGlyceraldehyde 3-phosphate dehydrogenaseMembrane proteinHSP60Peptide sequenceBacterial growthCytoplasmHuman pathogenPneumococcal infectionsHemeDehydrogenaseBacterial pneumoniaHelicobacter pyloriPathogenStreptococcus pneumoniaePlasma protein bindingBacteriaEscherichia coliBinding proteinBiochemistryCell growthChaperoninBiologyGroELMicrobiology
4Publications
4H-index
55Citations
Publications 4
Newest
#2Mario A. RodríguezH-Index: 17
Last. José de Jesús Olivares-Trejo (UACM: Universidad Autónoma de la Ciudad de México)H-Index: 11
view all 5 authors...
Streptococcus pneumoniae is a Gram-positive microorganism that is the cause of bacterial pneumonia, sinusitis and otitis media. This human pathogen also can cause invasive diseases such as meningitis, bacteremia and septicemia. Haemoglobin (Hb) and haem can support the growth and viability of S. pneumoniae as sole iron sources. Unfortunately, the acquisition mechanism of Hb and haem in this bacterium has been poorly studied. Previously we identified two proteins of 37 and 22 kDa as putative Hb- ...
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#1Zelene Edith Vázquez-Zamorano (UACM: Universidad Autónoma de la Ciudad de México)H-Index: 1
#2Marco Antonio González-López (UACM: Universidad Autónoma de la Ciudad de México)H-Index: 4
Last. José de Jesús Olivares-Trejo (UACM: Universidad Autónoma de la Ciudad de México)H-Index: 11
view all 6 authors...
Streptococcus pneumoniae is a gram positive encapsulated bacterium responsible of septicaemia and upper respiratory infections in children. This pathogen requires iron to survive in the host, which it can obtain of haemoglobin (Hb) or haem. Only two Hb-binding membrane proteins have been identified up to now. However it is unknown whether this pathogen secretes proteins in order to scavenge iron from the Hb or haem. Therefore, in order to explore these possibilities, cellular growth of S. pneumo...
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#1Marco Antonio González-López (UACM: Universidad Autónoma de la Ciudad de México)H-Index: 4
Last. José de Jesús Olivares-Trejo (UACM: Universidad Autónoma de la Ciudad de México)H-Index: 11
view all 4 authors...
Helicobacter pylori is a bacterium that can use multiple iron sources. However, it is unknown whether this bacterium secretes molecules such as siderophores or haemophores to scavenge iron. Here, we report the first secreted iron-binding protein of H. pylori, which we purified by haem-affinity chromatography. Mass spectrometry analysis revealed its identity as chaperonin (HpGroEL). When we compared HpGroEL with EcGroEL from Escherichia coli, they were homologous, showing 60% similarity. Addition...
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#1María Elena Romero-Espejel (UACM: Universidad Autónoma de la Ciudad de México)H-Index: 4
#2Marco Antonio González-López (UACM: Universidad Autónoma de la Ciudad de México)H-Index: 4
Last. José de Jesús Olivares-Trejo (UACM: Universidad Autónoma de la Ciudad de México)H-Index: 11
view all 3 authors...
Streptococcus pneumoniae, a human pathogen bacterium, can support its growth using haemoglobin (Hb) and haem as sole iron sources, but not when holo-transferrin or holo-lactoferrin is supplied. For this reason, it is easy to think that the principal iron sources for this pathogen inside humans are Hb and haem. Unfortunately, the mechanism has been poorly studied. The findings presented in this study are the first efforts that attempted to explain the mechanism involved in iron acquisition of thi...
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