Igor Astsaturov
Fox Chase Cancer Center
CancerInternal medicineSurgeryPathologyOncologyAntibodyImmunologyIn vivoChemotherapyEGFR inhibitorsNeuroendocrine tumorsEpidermal growth factor receptorCetuximabPancreatic cancerKRASIn patientCancer researchColorectal cancerCarcinogenesisSignal transductionMedicineBiologyCell biologyCancer cellPharmacology
118Publications
29H-index
2,424Citations
Publications 112
Newest
#2Ralph FrancesconeH-Index: 12
Last. Edna CukiermanH-Index: 43
view all 10 authors...
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#1Ralph Francescone (Fox Chase Cancer Center)H-Index: 12
#2Débora Barbosa Vendramini-Costa (Fox Chase Cancer Center)H-Index: 16
Last. Edna Cukierman (Fox Chase Cancer Center)H-Index: 43
view all 29 authors...
Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate and lacks effective therapeutics. Therefore, it is of paramount importance to identify new targets. Using multi-plex data from patient tissue, three-dimensional co-culturing in vitro assays, and orthotopic murine models, we identified Netrin G1 (NetG1) as a promoter of PDAC tumorigenesis. We found that NetG1+ cancer-associated fibroblasts (CAFs) support PDAC survival, through a NetG1 mediated effect on glutamate/glutamine me...
10 CitationsSource
#1William H. Ward (NMCP: Naval Medical Center Portsmouth)H-Index: 8
#2Caitlin R. Meeker (Fox Chase Cancer Center)H-Index: 4
Last. Michael J. Hall (Fox Chase Cancer Center)H-Index: 23
view all 17 authors...
PURPOSEPerformance status (PS) is a subjective assessment of patients' overall health. Quantification of physical activity using a wearable tracker (Fitbit Charge [FC]) may provide an objective mea...
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#1Rishi Jain (Fox Chase Cancer Center)H-Index: 4
#2Crystal S. Denlinger (Fox Chase Cancer Center)H-Index: 30
Last. Carolyn Y. Fang (Fox Chase Cancer Center)H-Index: 27
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465Background: Identification of poor dietary patterns is important for the optimal management of patients with metastatic GI malignancies who suffer from high rates of malnutrition and sarcopenia ...
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#1Linara Gabitova-Cornell (Fox Chase Cancer Center)H-Index: 1
#2Aizhan Surumbayeva (Fox Chase Cancer Center)H-Index: 1
Last. Igor Astsaturov (Kazan: Kazan Federal University)H-Index: 29
view all 24 authors...
Oncogenic transformation alters lipid metabolism to sustain tumor growth. We define a mechanism by which cholesterol metabolism controls the development and differentiation of pancreatic ductal adenocarcinoma (PDAC). Disruption of distal cholesterol biosynthesis by conditional inactivation of the rate-limiting enzyme Nsdhl or treatment with cholesterol-lowering statins switches glandular pancreatic carcinomas to a basal (mesenchymal) phenotype in mouse models driven by KrasG12D expression and ho...
5 CitationsSource
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#1Efrat Dotan (Fox Chase Cancer Center)H-Index: 18
#2Dana Backlund Cardin (VUMC: Vanderbilt University Medical Center)H-Index: 13
Last. Colin D. Weekes (Harvard University)H-Index: 26
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Background The recombinant fusion protein ipafricept (IPA) blocks Wnt signaling, and in combination with gemcitabine (G) and nab-paclitaxel (Nab-P) caused tumor regression in xenografts. This phase 1b study evaluated the combination of IPA with Nab-P+G in untreated metastatic PDAC (mPDAC) patients. Methods Dose escalation started with standard dose Nab-P+G and IPA (3.5 mg/kg days 1, 15). Due to fragility fractures seen with different anti-Wnt agents, following cohorts had >=6 patients treated wi...
4 CitationsSource
#1John J. KraisH-Index: 10
#2Emma ClausenH-Index: 4
Last. Neil F. JohnsonH-Index: 62
view all 6 authors...
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#1Ralph Francescone (Fox Chase Cancer Center)H-Index: 12
#2Débora Barbosa Vendramini-Costa (Fox Chase Cancer Center)H-Index: 16
Last. Edna Cukierman (Fox Chase Cancer Center)H-Index: 43
view all 30 authors...
Abstract Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate and lacks effective therapeutics. Therefore, it is of paramount importance to identify new targets. Using multi-plex data from patient tissue, three-dimensional co-culturing in vitro assays, and orthotopic murine models, we identified Netrin G1 (NetG1) as a promoter of PDAC tumorigenesis. NetG1+ cancer-associated fibroblasts (CAFs) supported PDAC survival, through a NetG1 mediated effect on glutamate/glutamine metab...
9 CitationsSource
#1Francesca Battaglin (SC: University of Southern California)H-Index: 16
#2Joanne XiuH-Index: 20
Last. Anthony B. El-Khoueiry (SC: University of Southern California)H-Index: 40
view all 20 authors...
4598Background: Isocitrate dehydrogenases (IDH) mutations (mut) identify a distinct subtype of BC that has yet to be fully characterized. We recently showed that IDH1/2 mutant (mIDH) BC harbor spec...
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