Guruprasad P. Aithal
University of Nottingham
Internal medicineRadiologySurgeryOdds ratioImmunologyLiver injuryLiver diseaseCirrhosisLiver biopsyFatty liverChronic liver diseaseDiseaseSteatohepatitisDrugFibrosisPopulationMedicineCohortBiologyGastroenterologyPharmacology
Publications 350
#2Jane I. GroveH-Index: 27
Last. Guruprasad P. AithalH-Index: 62
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Introduction null A Low Glycaemic Index (LGI) diet is a proposed lifestyle intervention in non-alcoholic fatty liver diseases (NAFLD) which is designed to reduce circulating blood glucose levels, hepatic glucose influx, insulin resistance and de novo lipogenesis. A significant reduction in liver fat content through following a 1-week LGI diet has been reported in healthy volunteers. Changes in dietary fat and carbohydrates have also been shown to alter gut microbiota composition and lead to hepa...
#1Scott A. Willis (Lboro: Loughborough University)H-Index: 4
#2Stephen Bawden (University of Nottingham)H-Index: 5
Last. James A. King (Lboro: Loughborough University)H-Index: 21
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Obesity is a primary antecedent to non-alcoholic fatty liver disease whose cardinal feature is excessive hepatic lipid accumulation. Although total hepatic lipid content closely associates with hepatic and systemic metabolic dysfunction, accumulating evidence suggests that the composition of hepatic lipids may be more discriminatory. This review summarises cross-sectional human studies using liver biopsy/lipidomics and proton magnetic resonance spectroscopy to characterise hepatic lipid composit...
#1Jane I. GroveH-Index: 27
#2Peggy Cho Kiu LoH-Index: 1
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Last. H. NiuH-Index: 4
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#1Amrita VijayH-Index: 4
Last. Guruprasad P. AithalH-Index: 62
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#2Vishal S. VaidyaH-Index: 47
Last. M. Isabel LucenaH-Index: 36
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#2Steven Masson (Newcastle University)H-Index: 21
Last. Devanshi Seth (Centenary Institute of Cancer Medicine and Cell Biology)H-Index: 21
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Background null The aMAP score (derived from age, male sex, albumin and platelet count) was recently devised to predict hepatocellular carcinoma (HCC) development. It was shown to have excellent performance irrespective of aetiology and ethnicity. Only one cohort of non-viral hepatitis patients (Japanese with mostly non-alcoholic fatty liver disease) was included in the validation set. Hence, the performance of the aMAP score among Caucasians with alcohol-related cirrhosis (ALC) is unknown. We a...
#1Mohsan Subhani (University of Nottingham)H-Index: 1
#2Abhishek Sheth (University of Nottingham)
Last. Joanne R Morling (University of Nottingham)H-Index: 16
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AIM: To assess the impact of Covid-19 on alcohol use disorders (AUD) and the role of universal alcohol screening (UAS) in an inpatient setting. METHODS: Retrospective cohorts were defined as pre-pandemic and pandemic admitted to Nottingham University Hospitals (April to October; 2019 and 2020) and had alcohol assessment by AUDIT-C. AUDIT-C score was assessed against age, sex, ethnicity, admission type, speciality and primary diagnosis of mental disorders. Subgroup analysis for Covid-19 positive ...
#2Theocharis Tsoleridis (University of Nottingham)H-Index: 4
Last. Adeel Ikram (University of Nottingham)
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Understanding the impact of prior infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the response to vaccination is a priority for responding to the coronavirus disease 2019 (COVID-19) pandemic. In particular, it is necessary to understand how prior infection plus vaccination can modulate immune responses against variants of concern. To address this, we sampled 20 individuals with and 25 individuals without confirmed previous SARS-CoV-2 infection from a large cohort o...
2 CitationsSource
#1Richard Mattock (Ebor: University of York)H-Index: 1
#2Dhiraj Tripathi (University Hospitals Birmingham NHS Foundation Trust)H-Index: 26
Last. Guruprasad P. Aithal (University of Nottingham)H-Index: 62
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Objectives null Transjugular intrahepatic portosystemic stent shunt (TIPSS) is clinically effective in variceal bleeding and refractory ascites; however, the cost-effectiveness of TIPSS has yet to be evaluated in the UK. This study aimed to establish the cost-effectiveness of (i) pre-emptive TIPSS versus endoscopic band ligation (EBL) in populations with variceal bleeding and (ii) TIPSS versus large volume paracentesis (LVP) in refractory ascites. null Methods null A cost-utility analysis was co...