Ralph H. Hruban
Johns Hopkins University School of Medicine
GeneCancerInternal medicineRadiologySurgeryPathologyOncologyIntraductal papillary mucinous neoplasmPancreatic diseaseCarcinomaPancreasPancreatic cancerAdenocarcinomaPancreatic Intraepithelial NeoplasiaCancer researchGeneticsCarcinogenesisMedicineBiologyGastroenterology
1,166Publications
208H-index
129kCitations
Publications 1172
Newest
#1Fang-Chi Hsu (Johns Hopkins University)
#2Nicholas J. Roberts (Johns Hopkins University)H-Index: 20
Last. George Zogopoulos (MUHC: McGill University Health Centre)H-Index: 23
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Importance null Pathogenic germline variants in the ATM gene have been associated with pancreatic cancer risk. Although genetic testing identifies these variants in approximately 1% to 3% of unselected patients with pancreatic cancer, the lifetime risk of pancreatic cancer among individuals with pathogenic ATM variants has not been well estimated. null Objective null To estimate age-specific penetrance of pancreatic cancer in individuals with a pathogenic variant in the ATM gene. null Design, se...
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Summary null Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor patient survival. Toward understanding the underlying molecular alterations that drive PDAC oncogenesis, we conducted comprehensive proteogenomic analysis of 140 pancreatic cancers, 67 normal adjacent tissues, and 9 normal pancreatic ductal tissues. Proteomic, phosphoproteomic, and glycoproteomic analyses were used to characterize proteins and their modifications. In addition, whole-genome sequencing, wh...
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#1Georgios Gemenetzis (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 17
#2Alex B. Blair (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 17
Last. Matthew J. Weiss (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 48
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#4Alex B. Blair (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 17
#9Jin He (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 40
OBJECTIVE. Pancreatic ductal adenocarcinoma (PDAC) is often a lethal malignancy with limited preoperative predictors of long-term survival. The purpose of this study was to evaluate the prognostic utility of preoperative CT radiomics features in predicting postoperative survival of patients with PDAC. MATERIALS AND METHODS. A total of 153 patients with surgically resected PDAC who underwent preoperative CT between 2011 and 2017 were retrospectively identified. Demographic, clinical, and survival...
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#1Laura Wake (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 1
#2Derek B. Allison (UK: University of Kentucky)H-Index: 10
Last. Michael J. Borowitz (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 87
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Pathologists who enter the workforce must have a diverse skill set beyond that of clinical diagnostics alone. Anticipating this need, the Johns Hopkins Pathology Residency Program developed Special Expertise Tracks to enhance training in relevant subspecialty domains. Using a combination of discussions and surveys, we assessed: (1) our current resident curriculum; (2) perceived curricular strengths and needs; (3) resident career preferences and ultimate career paths; (4) perceived barriers to im...
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#1Georgios Gemenetzis (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 17
#2Alex B. Blair (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 17
Last. Matthew J. Weiss (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 48
view all 19 authors...
BACKGROUND The introduction of multi-agent chemotherapy and radiation therapy has facilitated potential resection with curative intent in selected locally advanced pancreatic cancer (LAPC) patients with excellent outcomes. Nevertheless, there remains a remarkable lack of consensus on the management of LAPC. We sought to describe the outcomes of patients with LAPC and objectively define the multidisciplinary selection process for operative exploration based on anatomical factors. METHODS Consecut...
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#1Joseph R. Habib (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 6
#2Shamsher Pasha (JHUSOM: Johns Hopkins University School of Medicine)
Last. William R. Burns (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 6
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Pancreatic ductal adenocarcinoma (PDAC) has a high propensity for systemic dissemination. Ovarian metastases are rare and poorly described. We identified PDAC cases with ovarian metastasis from a prospectively maintained registry. We reported on the association between outcomes and clinicopathologic factors. Recurrence-free (RFS) and overall survival (OS) were calculated using Kaplan–Meier analysis. Twelve patients with PDAC and synchronous or metachronous ovarian metastases were identified. Nin...
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#1Amanda L. BlackfordH-Index: 56
#2Erica J. ChildsH-Index: 9
Last. Michele L. CoteH-Index: 35
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#1Linda C. ChuH-Index: 16
#2Seyoun ParkH-Index: 14
Last. Elliot K. FishmanH-Index: 133
view all 6 authors...
Computed tomography is the most commonly used imaging modality to detect and stage pancreatic cancer. Previous advances in pancreatic cancer imaging have focused on optimizing image acquisition parameters and reporting standards. However, current state-of-the-art imaging approaches still misdiagnose some potentially curable pancreatic cancers and do not provide prognostic information or inform optimal management strategies beyond stage. Several recent developments in pancreatic cancer imaging, i...
4 CitationsSource
#1Naziheh Assarzadegan (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 7
#2Elizabeth D. Thompson (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 20
Last. Ralph H. Hruban (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 208
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BACKGROUND Intraductal papillary mucinous neoplasms (IPMNs) represent a unique opportunity to treat and prevent a curable neoplasm before it has the chance to progress to incurable cancer. This prospect, however, has to be balanced with the real risk of over treating patients with lesions that would, in fact, never progress during the life of the patient. PURPOSE Informed clinical decisions in the treatment of IPMNs are first and foremost based on a deep understanding of the pathology of these l...
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