Nadia Zaffaroni
University of Milan
CancerInternal medicinePathologyOncologyMolecular biologyTelomereChemistryApoptosisIn vitroImmunologySurvivinCisplatinProstate cancerCancer researchCell growthMedicineCell cultureBiologyTelomeraseCancer cellPharmacology
Publications 404
#1Jessica Caciolla (UNIBO: University of Bologna)H-Index: 2
#2Silvia MartiniH-Index: 17
Last. Carmela Fimognari (UNIBO: University of Bologna)H-Index: 33
view all 13 authors...
Abstract null null Breast Cancer (BC) is a leading cause of death in women, currently affecting 13% of female population worldwide. First-line clinical treatments against Estrogen Receptor positive (ER+) BC rely on suppressing estrogen production, by inhibiting the aromatase (AR) enzyme, or on blocking estrogen-dependent pro-oncogenic signaling, by targeting Estrogen Receptor (ER) α with selective Modulators/Degraders (SERMs/SERDs). The development of dual acting molecules targeting AR and ERα r...
#1Carlotta Antoniotti (UniPi: University of Pisa)H-Index: 20
#2Federica Marmorino (UniPi: University of Pisa)H-Index: 15
Last. Elisa SottotettiH-Index: 8
view all 20 authors...
#1Chiara Platella (University of Naples Federico II)H-Index: 9
#2Stefania Mazzini (University of Milan)H-Index: 16
Last. Sabrina Dallavalle (University of Milan)H-Index: 26
view all 9 authors...
Stilbenoids are natural compounds endowed with several biological activities, including cardioprotection and cancer prevention. Among them, (±)- trans -δ-viniferin, deriving from trans -resveratrol dimerization, was here investigated in its ability to target DNA duplex and G-quadruplex structures by exploiting NMR, circular dichroism, fluorescence spectroscopy and molecular docking. (±)- trans -δ-Viniferin proved to bind both the minor and major grooves of duplexes, whereas it bound the 3'- and ...
Nucleic acid sequences able to adopt a G-quadruplex conformation are overrepresented within the human genome. This evidence strongly suggests that these genomic regions have been evolutionary selected to play a pivotal role in several aspects of cell biology. In the present review article, we provide an overview on the biological impact of targeting G-quadruplexes in cancer. A variety of small molecules showing good G-quadruplex stabilizing properties has been reported to exert an antitumor acti...
#1Silvia MartiniH-Index: 3
#2Valentina ZucoH-Index: 25
Last. Nadia ZaffaroniH-Index: 66
view all 10 authors...
Triple-negative breast cancer (TNBC) is an aggressive disease with limited therapeutic options. Here, we pursued a combinatorial therapeutic approach to enhance the activity of selinexor, the first-in-class XPO1 inhibitor, by miR-34a ectopic expression in human TNBC experimental models. Anti-proliferative activity induced by selinexor and miR-34a expression, singly and in combination, was evaluated by MTS assay and cell counting. The effect of treatments on survivin and apoptosis-related protein...
#1Giulia BertoliniH-Index: 13
#2Valeria Cancila (University of Palermo)H-Index: 10
Last. Luca RozH-Index: 31
view all 22 authors...
Abstract Platinum-based chemotherapy remains widely used in advanced non-small cell lung cancer (NSCLC) despite experimental evidence of its potential to induce long-term detrimental effects, including the promotion of pro-metastatic microenvironments. Here, we investigated the interconnected pathways underlying the promotion of cisplatin-induced metastases. In tumor-free mice, cisplatin treatment resulted in an expansion in the bone-marrow of CCR2+CXCR4+Ly6Chigh inflammatory monocytes (IM) and ...
1 CitationsSource
#1Paolo GandelliniH-Index: 25
Last. Nadia ZaffaroniH-Index: 66
view all 16 authors...
Active surveillance (AS) has evolved as a strategy alternative to radical treatments for very low risk and low-risk prostate cancer (PCa). However, current criteria for selecting AS patients are still suboptimal. Here, we performed an unprecedented analysis of the circulating miRNome to investigate whether specific miRNAs associated with disease reclassification can provide risk refinement to standard clinicopathological features for improving patient selection. The global miRNA expression profi...