Isabella Sperduti
Seconda Università degli Studi di Napoli
CancerInternal medicineSurgeryPathologyOncologyRetrospective cohort studyRandomized controlled trialStage (cooking)Metastatic breast cancerLung cancerChemotherapyIn patientCancer researchProportional hazards modelColorectal cancerBreast cancerMedicineBiologyGastroenterologyMeta-analysis
Publications 554
#1Marco Chiappetta (UCSC: Catholic University of the Sacred Heart)H-Index: 8
#2Giovanni LeuzziH-Index: 4
Last. Francesco FaccioloH-Index: 8
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BACKGROUND The prognostic role of the extension of lymphadenectomy in Non-small-cell lung cancer is still a debated and intriguing issue. The aim of this study is to validate a prognostic score including the number of resected lymph-nodes previously reported using a large multicentre dataset. METHODS From 01/2002 to 12/2012, data on 4858 NSCLC patients undergoing curative-intent surgery in six Institutions were retrospectively reviewed. To test the discriminative ability of the model, composed o...
#1Roberto GazzeriH-Index: 20
#2Stefano TeleraH-Index: 14
Last. Alex Alfieri (Winterthur Museum, Garden and Library)H-Index: 22
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PURPOSE Intradural extramedullary spinal metastases (IESM) represent an extremely rare manifestation of systemic cancer. We evaluated the surgical indications, complications and outcome in a series of 43 patients with solitary intradural extramedullary metastases originating from solid cancer of non-neurogenic origin. METHODS Patients' age, histopathological diagnoses of primary cancer, tumor size, spinal location, and extramedullary tumor dissemination were collected. Preoperative functional st...
#1Luca MoscettiH-Index: 20
#2Isabella SperdutiH-Index: 52
Last. Federico PiacentiniH-Index: 20
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In recent years, the number of trials incorporating health-related quality of life (HRQoL) data has increased. The impact of HRQoL on regulatory decision making in the European context and on clinical practice is not well established. We conducted an analysis of the role of QoL data extracted from the clinical trials of the drugs approved for hormone receptor positive/HER2-negative advanced/metastatic breast cancer (mBC). The results from the HRQoL were collected and a meta-analysis was performe...
#1Marco Chiappetta (UCSC: Catholic University of the Sacred Heart)H-Index: 8
#2Filippo Lococo (UCSC: Catholic University of the Sacred Heart)H-Index: 22
Last. Stylianos Korasidis (UniPi: University of Pisa)H-Index: 6
view all 16 authors...
ABSTRACT null null Objective null ITMIG classifies thymoma recurrences based on the topographic location, but its effectiveness in prognosis prediction has not been well investigated yet. Aims of this study are to analyse survival outcome of patients surgically treated for thymoma recurrence according to the ITMIG recurrence classification and to investigate possible alternatives. null null null Methods null From 01/01/1990 to 1/07/2017 data on 135 surgically treated patients for thymoma recurre...
#1Laura PizzutiH-Index: 20
#2Maddalena BarbaH-Index: 31
Last. Clara Natoli (University of Chieti-Pescara)H-Index: 32
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In metastatic breast cancer (mBC), the change of human epidermal growth factor receptor 2 (HER2) status between primary and metastatic lesions is widely recognized, however clinical implications are unknown. Our study address the question if relevant differences exist between subjects who preserve the HER2 status and those who gain the HER2 positivity when relapsed. Data of patients affected by HER2-positive mBC, treated with pertuzumab and/or trastuzumab-emtansine (T-DM1) in a real-world settin...
12 CitationsSource
#2Enrico MelisH-Index: 3
Last. Mauro CaterinoH-Index: 1
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#1Michele Signore (ISS: Istituto Superiore di Sanità)H-Index: 27
#2Romina Alfonsi (ISS: Istituto Superiore di Sanità)
Last. Giovanni Muto (Humanitas University)H-Index: 22
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Extracellular vesicles (EVs) and their cargo represent an intriguing source of cancer biomarkers for developing robust and sensitive molecular tests by liquid biopsy. Prostate cancer (PCa) is still one of the most frequent and deadly tumor in men and analysis of EVs from biological fluids of PCa patients has proven the feasibility and the unprecedented potential of such an approach. Here, we exploited an antibody-based proteomic technology, i.e. the Reverse-Phase Protein microArrays (RPPA), to m...
Central studies carried out on vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-COV2) excluded patients receiving immunosuppressive therapy and those diagnosed with an immunosuppressive condition. Moreover, there are no data on vaccine efficacy regarding older patients with cancer. OBJECTIVES: The primary objective was to evaluate the seroprevalence of the SARS-CoV2 IgG in older patients (aged ≥80 years) diagnosed with solid or hematological malignancies, one month afte...
#1Gian Maria Busetto (Policlinico Umberto I)H-Index: 19
#2Francesco Del Giudice (Policlinico Umberto I)H-Index: 13
Last. Alessandro Sciarra (Policlinico Umberto I)H-Index: 31
view all 11 authors...
PURPOSE To evaluate the diagnostic accuracy of SelectMDx and its association with multiparametric magnetic resonance (mpMRI) in predicting prostate cancer (PCa) and clinically significant PCa (csPCa) on prostate biopsies among men scheduled for initial prostate biopsy. METHODS In this single-center prospective study, 52 men scheduled for initial prostate biopsy, based on elevated total PSA level (> 3 ng/ml) or abnormal digital rectal examination, were consecutively included. All subjects underwe...
3 CitationsSource