Isao Date
Okayama University
Internal medicineRadiologyEndocrinologyDopaminergicSurgeryPathologyNeurotrophic factorsNeuroscienceAneurysmSubarachnoid hemorrhageGliomaParkinson's diseaseStriatumAngiogenesisTransplantationAnesthesiaCancer researchMedicineBiologyPharmacology
582Publications
58H-index
8,148Citations
Publications 581
Newest
#1Naoya Kidani (Okayama University)H-Index: 4
#2Kenji Sugiu (Okayama University)H-Index: 26
Last. Isao Date (Okayama University)H-Index: 58
view all 10 authors...
BACKGROUND The patients with ruptured vertebral artery dissecting aneurysm (rVADA) should be treated as early as possible because VADA carries extremely high risk of rebleeding in the acute phase. We have established a mobile endovascular strategy for the patients with rVADA between our flagship center and its affiliated local hospitals. We introduced and reviewed our mobile endovascular therapy in this study. METHODS We retrospectively evaluated 98 consecutive patients who underwent endovascula...
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#1Kazuki KobayashiH-Index: 17
#2Tadato YukiueH-Index: 1
Last. Tomoyuki OgawaH-Index: 3
view all 13 authors...
We developed a new cranioplasty method that utilizes artificial bone made of ultra-high-molecular-weight polyethylene, with a wedge-shaped edge (UHMWPE Wing). This study shows the methods and data of case series and finite element analyses with the UHMWPE Wing. A circumferential wing was preoperatively designed for a custom-made artificial bone made of UHMWPE to achieve high fixed power and to minimize the usage of cranial implants. Here, we present 4 years of follow-up data and finite element a...
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#1Tomohito Hishikawa (Okayama University)H-Index: 14
#2Satoshi Murai (Okayama University)H-Index: 5
Last. Isao Date (Okayama University)H-Index: 58
view all 16 authors...
The effectiveness of adenosine-induced flow arrest in surgical clipping for the cerebral aneurysms with difficulties in temporary clip placement to the proximal main trunk has been reported. This is the first clinical trial to evaluate the safety and feasibility of adenosine-assisted clipping surgery for unruptured cerebral aneurysms (UCAs) in Japan. The inclusion criteria are as follows: patients over 20 years old, patients who agree to be enrolled in this study after providing informed consent...
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#1Yusuke Tomita (Okayama University)H-Index: 6
#2Yosuke Shimazu (Okayama University)H-Index: 6
Last. Isao Date (Okayama University)H-Index: 58
view all 12 authors...
Ventriculitis is a rare, serious complication of neurosurgery. A 59-year-old man who had undergone a craniotomy for a paranasal adenocarcinoma, developed a right frontal cystic lesion. We performed a bifrontal craniotomy to remove the lesion. The dura was repaired with non-vascularized free fascia lata in watertight fashion. Ventriculitis occurred 3 days postoperatively. Ventricular drainage, craniectomy, and endoscopic irrigation were undertaken to remove an abscess. The dura and the resection ...
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#1Masahiro KamedaH-Index: 21
#2Eijiro Tokuyama (Okayama University)H-Index: 6
Last. Isao DateH-Index: 58
view all 4 authors...
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#1Yoshifumi Mizobuchi (University of Tokushima)H-Index: 14
#2Shinji Nagahiro (University of Tokushima)H-Index: 55
Last. Iwao YamakamiH-Index: 20
view all 27 authors...
BACKGROUND Microvascular decompression (MVD) is the most effective procedure for hemifacial spasm (HFS). MVD results from nonspecialized or low-volume institutes are not always reliable. Most studies on MVD for HFS are retrospective and single centered; to the best of our knowledge, no prospective, multicenter studies exist. OBJECTIVE To evaluate short- and long-term outcomes and complications in patients who underwent MVD for HFS in specialized Japanese institutions, in this multicenter, prospe...
1 CitationsSource
#1Yasuhiko HattoriH-Index: 5
Last. Yosuke ShimazuH-Index: 6
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#1Fusao Ikawa (Hiroshima University)H-Index: 16
#2Akio Morita (Nippon Medical School)H-Index: 49
Last. Hajime Arai (Juntendo University)H-Index: 35
view all 17 authors...
OBJECTIVE: Japan has been reported to have the highest (and increasing) incidence of subarachnoid hemorrhage (SAH) in the world. However, there has never been a report on the nationwide incidence rate and recent trends for SAH in Japan. In this register-based study, the authors aimed to clarify the estimated nationwide SAH incidence rate and the recent trend in SAH incidence in Japan and the reasons for any changes in this trend. METHODS: The authors compiled data from the Japanese Ministry of H...
3 CitationsSource
#1Atsuhito Uneda (Okayama University)H-Index: 8
#2Kazuhiko Kurozumi (Okayama University)H-Index: 23
Last. Isao Date (Okayama University)H-Index: 58
view all 15 authors...
Glioblastoma (GBM) is the most lethal primary brain tumor characterized by significant cellular heterogeneity, namely tumor cells, including GBM stem-like cells (GSCs) and differentiated GBM cells (DGCs), and non-tumor cells such as endothelial cells, vascular pericytes, macrophages, and other types of immune cells. GSCs are essential to drive tumor progression, whereas the biological roles of DGCs are largely unknown. In this study, we focused on the roles of DGCs in the tumor microenvironment....
2 CitationsSource