Merete Nordentoft
University of Copenhagen
PsychiatryInternal medicineMental healthPsychologyDanishRandomized controlled trialCognitionPediatricsCohort studyBipolar disorderDepression (differential diagnoses)PsychosisIntervention (counseling)PopulationPoison controlSuicide preventionClinical psychologyMedicineCohortSchizophrenia
Publications 875
#1Isabell Brikell (KI: Karolinska Institutet)H-Index: 13
Last. T. WergeH-Index: 6
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BackgroundADHD is multifactorial, yet the interplay ADHD polygenic risks scores (ADHD-PRS) and other ADHD associated risk-factors remains relatively unexplored. The aim of this study was to investigate associations, confounding and interactions of ADHD-PRS with birth, somatic and psychosocial risk-factors previously associated with ADHD. null MethodsParticipants came from the Danish iPSYCH2012 case-cohort, including a randomly selected general population sample (N=21,578), and all ADHD cases wit...
#1Frederike Schirmbeck (UvA: University of Amsterdam)H-Index: 21
#2Nadine C. van der Burg (UvA: University of Amsterdam)H-Index: 1
Last. Rodrigo A. Bressan (UNIFESP: Federal University of São Paulo)H-Index: 55
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Introduction null Diagnoses of anxiety and/or depression are common in subjects at Ultra-High Risk for Psychosis (UHR) and associated with extensive functional impairment. Less is known about the impact of affective comorbidities on the prospective course of attenuated psychotic symptoms (APS). null Method null Latent class mixed modelling identified APS trajectories in 331 UHR subjects assessed at baseline, 6, 12, and 24 months follow-up. The prognostic value of past, baseline, and one-year DSM...
#1Benedikte Kudahl (UCPH: University of Copenhagen)
#2Marie Eva Berg (Copenhagen University Hospital)
Last. Carsten Hjorthøj (Copenhagen University Hospital)H-Index: 31
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Abstract null null Background and purpose null Denmark launched a pilot program of medical cannabis in January 2018. The aim was to establish whether medical cannabis and cannabis-based medicine (MC/CBM) were superior and safe compared to conventional treatment, regardless of the indications for which people received such medication. null null null Materials and methods null People (cases) were identified who had redeemed at least one prescription of MC/CBM according to the nationwide, unselecte...
#1Sonja Orlovska-Waast (Copenhagen University Hospital)H-Index: 2
#2Liselotte Petersen (AU: Aarhus University)H-Index: 31
Last. Michael E. Benros (Copenhagen University Hospital)H-Index: 32
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BACKGROUND Cerebrospinal fluid (CSF) immune alterations have been associated with mental disorders, neurological disease, and CNS infections; however, comprehensive large-scale longitudinal CSF studies are lacking. METHODS By using the Clinical Laboratory Information System (LABKA) Research Database in the Central Denmark Region (1994-2012), we included 15,030 individuals tested for CSF WBC, CSF/serum albumin ratio, IgG index, total protein, albumin, or IgG with follow-up for the risk of mental ...
#1Tina Dam Kristensen (Centre for Mental Health)H-Index: 6
#2Louise Birkedal Glenthøj (Centre for Mental Health)H-Index: 8
Last. Birte Glenthøj (UCPH: University of Copenhagen)H-Index: 45
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OBJECTIVE: Psychosis spectrum disorders are associated with cerebral changes, but the prognostic value and clinical utility of these findings are unclear. Here, we applied a multivariate statistical model to examine the predictive accuracy of global white matter fractional anisotropy (FA) for transition to psychosis in individuals at ultra-high risk for psychosis (UHR). METHODS: 110 UHR individuals underwent 3 Tesla diffusion-weighted imaging and clinical assessments at baseline, and after 6 and...
#1Veera M. Rajagopal (Lundbeck)H-Index: 10
#2Jinjie Duan (Lundbeck)
Last. Marie Bækvad-Hansen (AU: Aarhus University)H-Index: 13
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Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder, with onset in childhood ("childhood ADHD"), and around two thirds of affected individuals will continue to have ADHD symptoms in adulthood ("persistent ADHD"). Age at first diagnosis can vary, and sometimes ADHD is first diagnosed in adulthood ("late-diagnosed ADHD"). null In this study, we analyzed a large Danish population-based case-cohort generated by iPSYCH in order to identify common genetic risk loci and per...
#1Kirstine Davidsen (University of Southern Denmark)H-Index: 4
#2Thomas Munk-Laursen (Lundbeck)
Last. Anne Thorup (CMHS: Mental Health Services)H-Index: 23
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OBJECTIVE Parental severe mental illness (SMI) increases the lifetime risk of mental and pediatric disorders in the offspring but little is known about specific disorders during early childhood. The primary aim was to investigate the incidence of mental and pediatric disorders among children 0-6 years old exposed to parental SMI, and secondarily to investigate the distribution of disorders on specific child age. METHODS A nationwide, register-based cohort study of 1,477,185 children born in Denm...
#1Tatjana Gazibara (University of Southern Denmark)H-Index: 13
#2Katherine A. Ornstein (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 24
Last. Lau Caspar Thygesen (University of Southern Denmark)H-Index: 30
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We aimed to examine the association of young and middle-aged sibling bereavement with use of health services and risk of developing mental health disorders over 24 months before and after sibling's death. All persons aged 18-56 years who died of illness/natural causes between 2009 and 2016 were identified in the Danish Register of Causes of Death. The study sample included 31,842 bereaved siblings and 31,842 age- and sex-matched controls. Overall, the largest effect was observed for increased us...
#1Thomas Nordahl Christensen (CMHS: Mental Health Services)
#2Iben Gammelgård Wallstrøm (University of Southern Denmark)H-Index: 1
Last. Merete Nordentoft (CMHS: Mental Health Services)H-Index: 96
view all 5 authors...
AIMS The study aimed to investigate time trends in incidence rates in schizophrenic spectrum disorders (ICD-10: F20-F29), bipolar affective disorder (ICD-10: F30, F31), and recurrent depression (ICD-10: F33) and to investigate the rates of employment for all incident cases. METHOD We used nationwide longitudinal data from 2000 to 2013 on all psychiatric inpatients and outpatients contacts in Denmark. Age-adjusted incidence rate ratios were calculated for the three diagnostic groups, and rates of...
#1Nina Vindegaard (Centre for Mental Health)H-Index: 2
#2Helene Speyer (Centre for Mental Health)H-Index: 1
Last. Michael Eriksen Benros (Centre for Mental Health)H-Index: 2
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Abstract Background Many diverse inflammatory pathophysiologic mechanisms have been linked to mental disorders, and through the past decade an increasing interest in the gut microbiota and its relation to mental health has been arising. We aimed to systematically review studies of alterations in gut microbiota of patients suffering from psychotic disorders, bipolar disorder or depression compared to healthy controls. Methods We systematically searched the databases CENTRAL, PubMed, EMBASE, PsycI...
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