Midori Awazu
Keio University
Internal medicineUrologyMitogen-activated protein kinaseEndocrinologySurgeryPathologyAmbulatory blood pressureRenal functionKinasePediatricsPrednisoloneKidney developmentDiseaseKidneyNephropathyp38 mitogen-activated protein kinasesNephrologyMAPK/ERK pathwayMedicineUrinary systemBlood pressureBiologyGastroenterologyCell biologyProtein kinase A
Publications 78
#1Midori Awazu (Keio: Keio University)H-Index: 19
#2Mamiko Yamada (Keio: Keio University)H-Index: 3
Last. Kazuya Matsumura (Keio: Keio University)H-Index: 2
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Mutations in the ciliary gene TTC21B, NPHP4, and CRB2 cause familial focal and segmental glomerulosclerosis (FSGS). We report a girl with a mutation of the ciliary gene CC2D2A presenting with FSGS and nephronophthisis. The patient had mental retardation, postaxial polydactyly, and ataxic breathing, and was diagnosed as having compound heterozygous CC2D2A missense mutations at age 5. Retrospectively, azotemia at 1 year and proteinuria at 5 years were recorded but not investigated. At age 6, she w...
#1Midori Awazu (Keio: Keio University)H-Index: 19
#2Yoshifumi Yamaguchi (UTokyo: University of Tokyo)H-Index: 17
Last. Mariko Hida (Keio: Keio University)H-Index: 14
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Abstract Inhibition of caspase-3 (Casp3) reduces ureteric branching in organ culture but the mechanism remains unclear. Since Casp3 has non-apoptotic functions, we examined whether Casp3 regulates ureteric branching by promoting cell migration, using a ureteric bud (UB) cell line and Casp3-deficient (Casp3−/−) mice. Also, we examined whether Casp3 plays a role in the reduced ureteric branching of metanephroi from nutrient restricted mothers, in which Casp3 activity is suppressed. A Casp3 inhibit...
#2Midori Awazu (Keio: Keio University)H-Index: 19
Last. Tomohiro Ishii (Keio: Keio University)H-Index: 22
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Summary We report a male infant with congenital nephrogenic diabetes insipidus (NDI) who presented with hypercalcemia and hyperphosphatemia since birth. Serum sodium started to increase at 39 days. Although there was no polyuria, urine osmolality was 71 mOsm/kg, when serum osmolality was 296 mOsm/kg with plasma arginine vasopressin 22.5 pg/mL. He was thus diagnosed as NDI. An undetectable level of urine calcium and unsuppressed intact parathyroid hormone suggested hyperparathyroidism including c...
#1Tatsuhiko AzegamiH-Index: 12
#2Keiko UchidaH-Index: 1
Last. Masaaki MoriH-Index: 47
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#1Tatsuhiko Azegami (Keio: Keio University)H-Index: 12
#2Keiko Uchida (Keio: Keio University)H-Index: 1
Last. Masaaki Mori (Keio: Keio University)H-Index: 47
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Early intervention to manage high blood pressure (BP) in young adulthood is a promising approach for the prevention of future cardiovascular diseases. We aimed to examine the ability of childhood health information to predict the incidence of young adults with high BP. This cohort study included baseline clinical data of Japanese individuals aged 12-13 years. A total of 1129 participants were followed up for an average of 8.6 years. We examined the association of childhood variables consisting o...
#1Takuma OhnishiH-Index: 2
#2Nariaki Asada (Keio: Keio University)H-Index: 2
Last. Isamu KamimakiH-Index: 4
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Urinary tract infection (UTI) is one of the most common bacterial infections in children. The symptoms of UTI in young children are nonspecific, therefore urine should be examined whenever UTI cannot be ruled out. In clinical settings, however, collecting urine from children who are not toilet trained is sometimes difficult, presenting a challenge in UTI management. Here, we developed a "diaper UTI test", which enables the quick detection of pyuria in ordinary diapers, and investigated its sensi...
#1Yuri DoteH-Index: 1
#2Tetsuya KibeH-Index: 1
Last. Midori Awazu (Keio: Keio University)H-Index: 19
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Ask-Upmark kidney (AUK) is a scarred segment of the kidney, characterized by formation of primitive tubular and glomerular structures, and sporadically diagnosed as a cause of hypertension (HTN). A 6-year-old girl with neurofibromatosis type 1 (NF1) and moyamoya syndrome had severe HTN. Based on past history, she had HTN at the age of 1.5 years. Laboratory examination revealed slightly elevated plasma and renal venous renin activity without lateralization. No evidence of pheochromocytoma, or coa...
#1Midori Awazu (Keio: Keio University)H-Index: 19
#2Mariko Hida (Keio: Keio University)H-Index: 14
We previously reported that maternal nutrient restriction (NR) inhibited ureteric branching, metanephric growth, and nephrogenesis in the rat. Here we examined whether folic acid, a methyl-group donor, rescues the inhibition of kidney development induced by NR and whether DNA methylation is involved in it. The offspring of dams given food ad libitum (CON) and those subjected to 50% food restriction (NR) were examined. NR significantly reduced ureteric tip number at embryonic day 14, which was at...
#2Sayu OmoriH-Index: 11
Last. Midori Awazu (Keio: Keio University)H-Index: 19
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