Sarah L. Gulliford
University College London
Internal medicineRadiologyUrologySurgeryOncologyLogistic regressionMedical physicsRadiation treatment planningProstateHead and neck cancerMucositisProstate cancerDysphagiaRectumProstate radiotherapyToxicityNuclear medicineDose distributionIncidence (epidemiology)Radiation therapyClinical trialMedicineDosimetryComplication
111Publications
23H-index
1,616Citations
Publications 108
Newest
#1Martin A. Ebert (SCGH: Sir Charles Gairdner Hospital)H-Index: 26
#2Sarah L. Gulliford (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 23
Last. Claudio Fiorino (UniSR: Vita-Salute San Raffaele University)H-Index: 54
view all 10 authors...
For decades, dose-volume information for segmented anatomy has provided the essential data for correlating radiotherapy dosimetry with treatment-induced complications. Dose-volume information has formed the basis for modelling those associations via normal tissue complication (NTCP) models and for driving treatment planning. Limitations to this approach have been identified. Many studies have emerged demonstrating that the incorporation of information describing the spatial nature of the dose di...
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#1Swee-Ling Wong (UCL: University College London)
#2J. Alshaikhi (UCL: University College London)
Last. R. Mendes (UCLH: University College London Hospitals NHS Foundation Trust)
view all 11 authors...
Abstract Aims Twenty per cent of patients with non-small cell lung cancer present with stage III locally advanced disease. Precision radiotherapy with pencil beam scanning (PBS) protons may improve outcomes. However, stage III is a heterogeneous group and accounting for complex tumour motion is challenging. As yet, it remains unclear as to whom will benefit. In our retrospective planning study, we explored if patients with superior sulcus tumours (SSTs) are a select cohort who might benefit from...
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#1Douglas Brand (ICR: Institute of Cancer Research)H-Index: 5
#2Sarah C. Brüningk (ETH Zurich)
Last. Sarah L. Gulliford (UCL: University College London)H-Index: 23
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Abstract Purpose Changes in fraction size of external beam radiotherapy (EBRT) exert non-linear impacts on subsequent toxicity. Commonly described by the linear-quadratic model, fraction size sensitivity of normal tissues is expressed by the α/β ratio. Here we study individual α/β ratios for different late rectal side effects after prostate EBRT. Methods and Materials The XXXXXXX trial (XX-REGISTRATION-NUMBER-XX) randomised men with non-metastatic prostate cancer 1:1:1 to 74Gy/37 fractions (Fr),...
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#1Douglas BrandH-Index: 5
#2Alison TreeH-Index: 20
Last. N. van AsH-Index: 16
view all 8 authors...
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#1Marco Marcello (UWA: University of Western Australia)H-Index: 3
#2James W. Denham (University of Newcastle)H-Index: 56
Last. Martin A. Ebert (UWA: University of Western Australia)H-Index: 26
view all 16 authors...
Abstract Background and purpose This study aimed to identify anatomically-localised regions where planned radiotherapy dose is associated with gastrointestinal toxicities in healthy tissues throughout the pelvic anatomy. Materials and methods Planned dose distributions for up to 657 patients of the Trans Tasman Radiation Oncology Group 03.04 RADAR trial were deformably registered onto a single exemplar computed tomography dataset. Voxel-based multiple comparison permutation dose difference testi...
2 CitationsSource
#1Marco Marcello (UWA: University of Western Australia)H-Index: 3
#2James W. Denham (University of Newcastle)H-Index: 56
Last. Martin A. Ebert (UWA: University of Western Australia)H-Index: 26
view all 16 authors...
Purpose Reducing margins during treatment planning to decrease dose to healthy organs surrounding the prostate can risk inadequate treatment of subclinical disease. This study aimed to investigate whether lack of dose to subclinical disease is associated with increased disease progression by utilizing high-quality prostate radiotherapy clinical trial data to identify anatomically-localised regions where dose variation is associated with PSA progression (PSAP). Methods and Materials Planned dose ...
2 CitationsSource
#1Marco Marcello (UWA: University of Western Australia)H-Index: 3
#2James W. Denham (University of Newcastle)H-Index: 56
Last. Martin A. Ebert (UWA: University of Western Australia)H-Index: 26
view all 16 authors...
Purpose: Dose information from organ sub-regions has been shown to be more predictive of genitourinary toxicity than whole organ dose volume histogram information. This study aimed to identify anatomically-localised regions where 3D dose is associated with genitourinary toxicities in healthy tissues throughout the pelvic anatomy. Methods and Materials: Dose distributions for up to 656 patients of the Trans-Tasman Radiation Oncology Group 03.04 RADAR trial were deformably registered onto a single...
1 CitationsSource
#1Matthew Lowe (University of Manchester)H-Index: 7
#2A. Gosling (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 1
Last. Sarah L. Gulliford (UCL: University College London)H-Index: 23
view all 13 authors...
Abstract In the UK, the recent introduction of high-energy proton beam therapy into national clinical practice provides an opportunity for new clinical trials, particularly those comparing proton and photon treatments. However, comparing these different modalities can present many challenges. Although protons may confer an advantage in terms of reduced normal tissue dose, they can also be more sensitive to uncertainty. Uncertainty analysis is fundamental in ensuring that proton plans are both sa...
2 CitationsSource
#1Julia Murray (ICR: Institute of Cancer Research)H-Index: 6
#2S. Gulliford (ICR: Institute of Cancer Research)H-Index: 1
Last. CHHiP InvestigatorsH-Index: 3
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Abstract Background and purpose The penile bulb (PB) dose may be critical in development of post prostate radiotherapy erectile dysfunction (ED). This study aimed to generate PB dose constraints based on dose-volume histograms (DVHs) in patients treated with prostate radiotherapy, and to identify clinical and dosimetric parameters that predict the risk of ED post prostate radiotherapy. Materials and methods Penile bulb DVHs were generated for 276 patients treated within the randomised IGRT subst...
7 CitationsSource
#1Sarah L. Kerns (URMC: University of Rochester Medical Center)H-Index: 27
#2Laura FachalH-Index: 24
Last. Catharine M L West (MAHSC: Manchester Academic Health Science Centre)H-Index: 77
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BACKGROUND: 10-20% of patients develop long-term toxicity following radiotherapy for prostate cancer. Identification of common genetic variants associated with susceptibility to radiotoxicity might improve risk prediction and inform functional mechanistic studies. METHODS: We conducted an individual patient data meta-analysis of six genome-wide association studies (n = 3,871) in men with European ancestry who underwent radiotherapy for prostate cancer. Radiotoxicities (increased urinary frequenc...
23 CitationsSource