Zane T. Hammoud
Henry Ford Health System
GlycoproteinCancerRadiologySurgeryPathologyGlycoproteomicsGlycanDysplasiaLung cancerEsophagectomyGlycosylationLungEsophagusEsophageal diseaseMediastinal fibrosisAdenocarcinomaIdiopathic Retroperitoneal FibrosisRadiation therapyMedicineBiomarker (medicine)
Publications 32
#1Simona Cazacu (HFHS: Henry Ford Health System)H-Index: 9
#2Wei Jiang (HFHS: Henry Ford Health System)H-Index: 1
Last. Chaya Brodie (HFHS: Henry Ford Health System)H-Index: 5
view all 7 authors...
#1Ko Un Park (HFHS: Henry Ford Health System)H-Index: 1
#2Ilan Rubinfeld (HFHS: Henry Ford Health System)H-Index: 22
Last. Zane T. Hammoud (HFHS: Henry Ford Health System)H-Index: 15
view all 4 authors...
Background Although influence of technical complications in association to hospital length of stay has been studied extensively in esophageal resection, nontechnical factors responsible for prolonged length of stay have not been reported. Using the NSQIP dataset, we hypothesized that we would be able to identify factors associated with prolonged length of stay after esophagectomy. Study Design National Surgical Quality Improvement Program data from 2005 to 2012 were reviewed for CPT codes for es...
14 CitationsSource
#1Ning Wen (HFHS: Henry Ford Health System)H-Index: 17
#2H Li (HFHS: Henry Ford Health System)H-Index: 8
Last. M. Salim Siddiqui (HFHS: Henry Ford Health System)H-Index: 9
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The purpose of this study is to characterize the dosimetric properties and accuracy of a novel treatment platform (Edge radiosurgery system) for localizing and treating patients with frameless, image-guided stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT). Initial measurements of various components of the system, such as a comprehensive assessment of the dosimetric properties of the flattening filter-free (FFF) beams for both high definition (HD120) MLC and conical cone-...
22 CitationsSource
#1Sanath Kumar (HFHS: Henry Ford Health System)H-Index: 11
#2Benjamin Movsas (HFHS: Henry Ford Health System)H-Index: 43
Last. Renate Parry (Varian Medical Systems)H-Index: 7
view all 18 authors...
1 CitationsSource
#1Ehwang Song (TTU: Texas Tech University)H-Index: 14
#2Rui Zhu (TTU: Texas Tech University)H-Index: 9
Last. Yehia Mechref (TTU: Texas Tech University)H-Index: 51
view all 4 authors...
Changes in glycosylation have been shown to have a profound correlation with development/malignancy in many cancer types. Currently, two major enrichment techniques have been widely applied in glycoproteomics, namely, lectin affinity chromatography (LAC)-based and hydrazide chemistry (HC)-based enrichments. Here we report the LC–MS/MS quantitative analyses of human blood serum glycoproteins and glycopeptides associated with esophageal diseases by LAC- and HC-based enrichment. The separate and co...
49 CitationsSource
#1Sanath Kumar (HFHS: Henry Ford Health System)H-Index: 11
#2Benjamin Movsas (HFHS: Henry Ford Health System)H-Index: 43
Last. Renate Parry (Varian Medical Systems)H-Index: 7
view all 18 authors...
#1Anoop Mayampurath (IU: Indiana University)H-Index: 18
#2Ehwang Song (TTU: Texas Tech University)H-Index: 14
Last. Haixu Tang (IU: Indiana University)H-Index: 44
view all 7 authors...
Glycan moieties of glycoproteins modulate many biological processes in mammals, such as immune response, inflammation, and cell signaling. Numerous studies show that many human diseases are correlated with quantitative alteration of protein glycosylation. In some cases, these changes can occur for certain types of glycans over specific sites in a glycoprotein rather than on the global abundance of the glycoprotein. Conventional analytical techniques that analyze the abundance of glycans cleaved ...
38 CitationsSource
#1M. M. GayeH-Index: 5
#2Stephen J. Valentine (IU: Indiana University)H-Index: 35
Last. David E. Clemmer (IU: Indiana University)H-Index: 60
view all 8 authors...
Three disease phenotypes, Barrett’s esophagus (BE), high-grade dysplasia (HGD), esophageal adenocarcinoma (EAC), and a set of normal control (NC) serum samples are examined using a combination of ion mobility spectrometry (IMS), mass spectrometry (MS), and principal component analysis (PCA) techniques. Samples from a total of 136 individuals were examined, including 7 characterized as BE, 12 as HGD, 56 as EAC, and 61 as NC. In typical data sets, it was possible to assign ∼20 to 30 glycan ions ba...
41 CitationsSource
#1Chady Haurani (HFHS: Henry Ford Health System)H-Index: 1
#2Arthur M. Carlin (HFHS: Henry Ford Health System)H-Index: 16
Last. Vic Velanovich (USF: University of South Florida)H-Index: 43
view all 4 authors...
Background Paraesophageal hernias may produce a variety of clinical sequelae including anemia and esophagogastric ulcerations or erosions. We examined the prevalence of anemia in patients with paraesophageal hernias and frequency of anemia resolution with hernia repair.
16 CitationsSource
#1Indranil MitraH-Index: 5
#2Zexi Zhuang (IU: Indiana University)H-Index: 4
Last. Stephen C. Jacobson (IU: Indiana University)H-Index: 49
view all 8 authors...
We report analysis of N-glycans derived from disease-free individuals and patients with Barrett’s esophagus, high-grade dysplasia, and esophageal adenocarcinoma by microchip electrophoresis with laser-induced fluorescence detection. Serum samples in 10 μL aliquots are enzymatically treated to cleave the N-glycans that are subsequently reacted with 8-aminopyrene-1,3,6-trisulfonic acid to add charge and a fluorescent label. Separations at 1250 V/cm and over 22 cm yielded efficiencies up to 700 000...
36 CitationsSource
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