Norbert V. Heeb
Swiss Federal Laboratories for Materials Science and Technology
GasolineCombustionEnvironmental chemistryAnalytical chemistryDiesel particulate filterDiesel fuelCatalysisAutomotive engineeringOrganic chemistryChemistryParticulatesSootBenzeneCatalytic converterExhaust gasDiesel exhaustEnvironmental scienceEnantiomerWaste managementStereochemistryEnvironmental engineering
105Publications
30H-index
3,547Citations
Publications 103
Newest
#1Alwyn Fernandes (UEA: University of East Anglia)H-Index: 11
#2Walter Vetter (University of Hohenheim)H-Index: 53
Last. Kerstin Krätschmer (EU: European Union)H-Index: 6
view all 9 authors...
Abstract null null The determination of chlorinated paraffins (CPs) has posed an intractable challenge in analytical chemistry for over three decades. The combination of an as yet unspecifiable number (tens - hundreds of thousands) of individual congeners in mass produced commercial CP mixtures and the steric interactions between them, contrive to defy efforts to characterise their residual occurrences in environmental compartments, food and human tissues. However, recent advances in instrumenta...
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#1Marco C. Knobloch (UZH: University of Zurich)H-Index: 2
#2Flurin Mathis (Zurich University of Applied Sciences/ZHAW)
Last. Norbert V. Heeb (Empa: Swiss Federal Laboratories for Materials Science and Technology)H-Index: 30
view all 7 authors...
Abstract null null Transformation studies of chlorinated paraffins (CPs) and the effects of CP transformation products on humans, biota and environment are rare. The focus here is on hydroxylation reactions. As for polyhalogenated persistent organic pollutants (POPs) in general, hydroxylation reactions convert lipophilic material to more polar compounds with increased mobility. We investigated the in-vitro transformation of single-chain CP-mixtures to hydroxylated products with the dehalogenase ...
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#1Marco C. Knobloch (Empa: Swiss Federal Laboratories for Materials Science and Technology)H-Index: 2
#2Jannik Sprengel (University of Hohenheim)H-Index: 7
Last. Norbert V. Heeb (Empa: Swiss Federal Laboratories for Materials Science and Technology)H-Index: 30
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Abstract null null Technical chlorinated paraffins (CPs) are produced via radical chlorination of n-alkane feedstocks with different carbon chain-lengths (∼C10–C30). Short-chain CPs (SCCPs, C10–C13) are classified as persistent organic pollutants (POPs) under the Stockholm Convention. This regulation has induced a shift to use longer-chain CPs as substitutes. Consequently, medium-chain (MCCPs, C14–C17) and long-chain (LCCPs, C > 17) CPs have become dominant homologues in recent environmental sam...
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#1Marco C. Knobloch (UZH: University of Zurich)H-Index: 2
#2Lena Schinkel (Eawag: Swiss Federal Institute of Aquatic Science and Technology)H-Index: 2
Last. Norbert V. Heeb (Empa: Swiss Federal Laboratories for Materials Science and Technology)H-Index: 30
view all 7 authors...
Abstract null null Structure, reactivity and physico-chemical properties of polyhalogenated compounds determine their up-take, transport, bio-accumulation, transformation and toxicity and their environmental fate. In technical mixtures of chlorinated paraffins (CPs), these properties are distributed due to the presence of thousands of homologues. We hypothesized that roles of CP dehalogenation reactions, catalyzed by the haloalkane dehalogenase LinB, depend on structural properties of the substr...
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#1María Isabel Vera Muñoz (Empa: Swiss Federal Laboratories for Materials Science and Technology)H-Index: 9
#2Regula Haag (Empa: Swiss Federal Laboratories for Materials Science and Technology)H-Index: 12
Last. Norbert V. Heeb (Empa: Swiss Federal Laboratories for Materials Science and Technology)H-Index: 30
view all 8 authors...
The use of reclaimed asphalt pavement (RAP) is of increasing importance due to fast-growing amounts of demolished road materials. However, reclaimed asphalt can contain relevant amounts of pollutan...
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#1Norbert V. Heeb (Empa: Swiss Federal Laboratories for Materials Science and Technology)H-Index: 30
#2Jasmin Hubeli (Zurich University of Applied Sciences/ZHAW)H-Index: 1
Last. Hans-Peter E. Kohler (Eawag: Swiss Federal Institute of Aquatic Science and Technology)H-Index: 59
view all 7 authors...
Abstract Hexabromocyclododecanes (HBCDs) were used as flame-retardants until their ban in 2013. Among the 16 stereoisomers known, e-HBCD has the highest symmetry. This makes e-HBCD an interesting substrate to study the selectivity of biotransformations. We expressed three LinA dehydrohalogenase enzymes in E. coli bacteria, two wild-type, originating from Sphingobium indicum B90A bacteria and LinATM, a triple mutant of LinA2, with mutations of L96C, F113Y and T133 M. These enzymes are involved in...
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#1Marco C. Knobloch (Empa: Swiss Federal Laboratories for Materials Science and Technology)H-Index: 2
#2Lena Schinkel (Eawag: Swiss Federal Institute of Aquatic Science and Technology)H-Index: 2
Last. Norbert V. Heeb (Empa: Swiss Federal Laboratories for Materials Science and Technology)H-Index: 30
view all 7 authors...
Abstract Short-chain chlorinated paraffins (SCCPs) are listed as persistent organic pollutants (POPs) under the Stockholm Convention. Such substances are toxic, bioaccumulating, transported over long distances and degrade slowly in the environment. Certain bacterial strains of the Sphingomonadacea family are able to degrade POPs, such as hexachlorocyclohexanes (HCHs) and hexabromocyclododecanes (HBCDs). The haloalkane dehalogenase LinB, expressed in certain Sphingomonadacea, is able to catalyze ...
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#1Norbert V. Heeb (Empa: Swiss Federal Laboratories for Materials Science and Technology)H-Index: 30
#2Silvan Iten (Empa: Swiss Federal Laboratories for Materials Science and Technology)H-Index: 1
Last. Walter Vetter (University of Hohenheim)H-Index: 53
view all 8 authors...
Abstract The photolytic chlorination of n-alkanes in presence of sulfuryl chloride (SO2Cl2) was explored to produce new standard materials. Five mixtures of chlorinated tetradecanes were synthesized with chlorination degrees (mCl,EA) varying from 43.7% to 59.4% (m/m) based on elemental analysis. Chlorine-enhanced negative chemical ionization mass spectrometry (CE–NCI–MS) forcing the formation of chloride-adduct ions [M+Cl]- was applied to characterize these materials which all contained tetra-to...
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#1Lena Schinkel (Empa: Swiss Federal Laboratories for Materials Science and Technology)H-Index: 7
#2Elia Canonica (Empa: Swiss Federal Laboratories for Materials Science and Technology)H-Index: 1
Last. Norbert V. HeebH-Index: 30
view all 5 authors...
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#1Norbert V. Heeb (Empa: Swiss Federal Laboratories for Materials Science and Technology)H-Index: 30
#2Simone Schalles (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 2
Last. Hans-Peter E. Kohler (Eawag: Swiss Federal Institute of Aquatic Science and Technology)H-Index: 59
view all 8 authors...
Abstract Short-chain chlorinated paraffins (SCCPs) are polyhalogenated hydrocarbons as are hexachlorocyclohexanes (HCHs) and hexabromocyclododecanes (HBCDs). They all have been classified as persistent organic pollutants (POPs) under the UN Stockholm Convention. Per se such compounds are transformed slowly in the environment, transported over long distances and accumulate in biota. Several Sphingomonadacea strains isolated from HCH dump sites have evolved to express enzymes that can transform HC...
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