Niels Bergsland
State University of New York System
Internal medicinePathologyMagnetic resonance imagingDiffusion MRIPsychologyCardiologyNeuroscienceCognitionThalamusPutamenMultiple sclerosisExpanded Disability Status ScaleClinically isolated syndromeLesionAtrophyWhite matterNuclear medicineIn patientBrain sizeMedicineGastroenterology
291Publications
40H-index
4,551Citations
Publications 278
Newest
#1Eleonora Tavazzi (SUNY: State University of New York System)H-Index: 22
#2Marta CazzoliH-Index: 1
Last. Francesca BaglioH-Index: 23
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Background: Motor rehabilitation is routinely used in clinical practice as an effective method to reduce progressive disability gain in multiple sclerosis (MS), but rehabilitation approaches are typically unstandardized, and only few studies have investigated the impact of rehabilitation on brain neuroplasticity. Objective: To summarize and critically analyze studies applying MRI markers of functional connectivity and structural changes to assess the effect of motor rehabilitation on brain neuro...
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#1Tomas Uher (University of Melbourne)H-Index: 16
#2Eva Havrdova (First Faculty of Medicine, Charles University in Prague)H-Index: 72
Last. Manuela Vaneckova (First Faculty of Medicine, Charles University in Prague)H-Index: 26
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Background:The added value of neurofilament light chain levels in serum (sNfL) to the concept of no evidence of disease activity-3 (NEDA-3) has not yet been investigated in detail.Objective:To asse...
1 CitationsSource
#1Francesca BaglioH-Index: 23
#2Alice PirastruH-Index: 3
Last. Eleonora Tavazzi (UB: University at Buffalo)H-Index: 22
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Parkinson's disease (PD) is the second most common neurological disease affecting the elderly population. Pharmacological and surgical interventions usually employed for PD treatment show transient effectiveness and are associated with the insurgence of side effects. Therefore, motor rehabilitation has been proposed as a promising supplement in the treatment of PD, reducing the global burden of the disease and improving patients quality of life. The present systematic review aimed to critically ...
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#1Michael Barnett (USYD: University of Sydney)H-Index: 70
#2Niels Bergsland (UB: University at Buffalo)H-Index: 40
Last. Juan Ignacio Rojas (Hospital Italiano de Buenos Aires)H-Index: 18
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BACKGROUND: Methodological challenges limit the use of brain atrophy and lesion burden measures in the follow-up of multiple sclerosis (MS) patients on clinical routine datasets. OBJECTIVE: To determine the feasibility of T2-FLAIR-only measures of lateral ventricular volume (LVV) and salient central lesion volume (SCLV), as markers of disability progression (DP) in MS. METHODS: A total of 3,228 MS patients from 9 MSBase centers in 5 countries were enrolled. Of those, 2,875 (218 with clinically i...
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#1Dejan Jakimovski (SUNY: State University of New York System)H-Index: 16
#2Michael G. Dwyer (SUNY: State University of New York System)H-Index: 54
Last. Robert Zivadinov (SUNY: State University of New York System)H-Index: 83
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The continuous neuroinflammatory and neurodegenerative pathology in multiple sclerosis (MS) results in irreversible accumulation of physical and cognitive disability. Reliable early detection of MS disease processes can aid in the diagnosis, monitoring and treatment management of MS patients. Recent assay technological advancements now allow reliable quantification of serum-based neurofilament light chain (sNfL) levels, which provide temporal information regarding the degree of neuroaxonal damag...
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#1Niels Bergsland (SUNY: State University of New York System)H-Index: 40
#2Michael G. Dwyer (SUNY: State University of New York System)H-Index: 54
Last. Robert Zivadinov (SUNY: State University of New York System)H-Index: 83
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BACKGROUND AND PURPOSE Atrophied T2 lesion volume (LV), reflecting the complete transformation of lesions into cerebrospinal fluid (CSF), has been associated with disease progression in multiple sclerosis (MS). The underlying damage leading to lesion destruction remains poorly understood. The objective of this study was to use diffusion tensor imaging (DTI) to investigate the extent of microstructural tissue damage at baseline in lesions that subsequently transform into CSF. METHODS Ninety-nine ...
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The aim of this study was to develop and validate an MRI protocol based on a variable echo time (vTE) sensitive to the short T2* components of the sciatic nerve. 15 healthy subjects (M/F: 9/6; age: 21–62) were scanned at 3T targeting the sciatic nerve at the thigh bilaterally, using a dual echo variable echo time (vTE) sequence (based on a spoiled gradient echo acquisition) with echo times of 0.98/5.37 ms. Apparent T2* (aT2*) values of the sciatic nerves were calculated with a mono-exponential f...
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#1Tom A. Fuchs (SUNY: State University of New York System)H-Index: 10
#2Michael G. Dwyer (SUNY: State University of New York System)H-Index: 54
Last. Robert Zivadinov (SUNY: State University of New York System)H-Index: 83
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Abstract Background Although quantitative measures from research-quality MRI provide a means to study multiple sclerosis (MS) pathology in vivo, these metrics are often unavailable in legacy clinical datasets. Objective To determine how well an automatically-generated quantitative snapshot of brain pathology, measured only on clinical routine T2-FLAIR MRI, can substitute for more conventional measures on research MRI in terms of capturing multi-factorial disease pathology and providing similar c...
1 CitationsSource
#1Franziska E Hildesheim (SUNY: State University of New York System)
#2Ralph H. B. Benedict (UB: University at Buffalo)H-Index: 81
Last. Niels Bergsland (SUNY: State University of New York System)H-Index: 40
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BACKGROUND The nucleus basalis of Meynert (NBM), representing the major source of cerebral cholinergic innervations, is vulnerable to neurodegeneration in Alzheimer's and Parkinson's disease. OBJECTIVE To determine associations between NBM properties and cognitive outcomes in patients with multiple sclerosis (PwMS). METHODS 84 PwMS and 19 controls underwent 3T MRI, the Paced Auditory Serial Addition Test (PASAT) and subtests of the Brief International Cognitive Assessment for MS (BICAMS). NBM vo...
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#1Tomas UherH-Index: 16
#2Jan KrasenskyH-Index: 24
Last. Tomas KalincikH-Index: 32
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Objective To describe the dynamics of brain volume loss (BVL) at different stages of relapsing-remitting multiple sclerosis (RRMS), to describe the association between BVL and clinical measures, and to investigate an effect of treatment escalation on the rate of BVL. Methods Together, 1903 patients predominantly with RRMS from the Avonex-Steroids-Azathioprine cohort (N = 166), the study of early IFN-β1a treatment cohort (N = 180), and the quantitative MRI cohort (N = 1,557) with ≥2 MRI scans and...
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