Thomas Bjarnsholt
Copenhagen University Hospital
Quorum sensingMultidrug tolerancePathologyChemistryImmunologyIn vivoSputumCystic fibrosisFluorescence in situ hybridizationPseudomonas aeruginosaLungStaphylococcus aureusAntimicrobialAntibioticsBacteriaBiofilmVirulenceMedicineBiologyMicrobiology
Publications 281
#1Mads Lichtenberg (UCPH: University of Copenhagen)H-Index: 11
#2Laura Line (UCPH: University of Copenhagen)H-Index: 4
Last. Peter Østrup Jensen (UCPH: University of Copenhagen)H-Index: 57
view all 12 authors...
Summary null null Denitrification supports anoxic growth of Pseudomonas aeruginosa in infections. Moreover, denitrification may provide oxygen (O2) resulting from dismutation of the denitrification intermediate nitric oxide (NO) as seen in Methylomirabilis oxyfera. To examine the prevalence of NO dismutation we studied O2 release by P. aeruginosa in airtight vials. P. aeruginosa rapidly depleted O2 but NO supplementation generated peaks of O2 at the onset of anoxia, and we demonstrate a direct r...
#1Jan Lorenzen (Danish Technological Institute)
#2Yijuan XuH-Index: 10
Last. Trine Rolighed ThomsenH-Index: 25
view all 7 authors...
#1Henriette Lyng Røder (UCPH: University of Copenhagen)H-Index: 13
#2Urvish Trivedi (UCPH: University of Copenhagen)H-Index: 12
Last. Jonas Stenløkke Madsen (UCPH: University of Copenhagen)H-Index: 13
view all 10 authors...
Plasmids facilitate rapid bacterial adaptation by shuttling a wide variety of beneficial traits across microbial communities. However, under non-selective conditions, maintaining a plasmid can be costly to the host cell. Nonetheless, plasmids are ubiquitous in nature where bacteria adopt their dominant mode of life - biofilms. Here, we demonstrate that biofilms can act as spatiotemporal reserves for plasmids, allowing them to persist even under non-selective conditions. However, under these cond...
#1Naireen Fatima (UCPH: University of Copenhagen)
#2Thomas Bjarnsholt (UCPH: University of Copenhagen)H-Index: 71
Last. Lene Bay (UCPH: University of Copenhagen)H-Index: 7
view all 3 authors...
Post-surgical infections arise due to various contributing factors. Most important is the presence of potential pathogenic microorganisms in the skin complemented by the patient´s health status. Cutibacterium acnes is commonly present in the pilosebaceous glands and hair follicle funnels in human skin. After surgical intervention, these highly prevalent, slow-growing bacteria can be found in the deeper tissues and in proximity of implants. C. acnes is frequently implicated in post-surgical infec...
#1Elin JørgensenH-Index: 3
#2Thomas BjarnsholtH-Index: 71
Last. Stine JacobsenH-Index: 27
view all 3 authors...
In chronic wounds in humans, biofilm formation and wound chronicity are linked, as biofilms contribute to chronic inflammation and delayed healing. Biofilms are aggregates of bacteria, and living as biofilms is the default mode of bacterial life; within these aggregates, the bacteria are protected from both antimicrobial substances and the immune response of the host. In horses, delayed healing is more commonly seen in limb wounds than body wounds. Chronic inflammation and hypoxia are the main c...
#2Urvish TrivediH-Index: 12
Last. Jonas Stenløkke MadsenH-Index: 13
view all 10 authors...
#1Thomas Bjarnsholt (Copenhagen University Hospital)H-Index: 71
#2Marvin Whiteley (Georgia Institute of Technology)H-Index: 63
Last. Niels Frimodt-Møller (Copenhagen University Hospital)H-Index: 9
view all 6 authors...
Standard doses of antibiotics do not efficiently treat chronic infections of the soft tissue and bone. In this Personal View, we advocate for improving treatment of these infections by taking the infectious microenvironment into account. The infectious microenvironment can cause sensitive bacteria to lose their susceptibility to antibiotics that are effective in standard laboratory susceptibility testing. We propose that bacteria behave substantially different in standard laboratory conditions t...
#1Hans Christian Ring (UCPH: University of Copenhagen)H-Index: 15
#2Jonathan Thorsen (UCPH: University of Copenhagen)H-Index: 19
Last. Gregor B.E. Jemec (UCPH: University of Copenhagen)H-Index: 87
view all 8 authors...
New avenues for potential treatments or clinically applicable biomarkers for hidradenitis suppurativa (HS) may be discovered in view of the recent findings by several Next Generation 16S rRNA gene sequencing (NGS) studies on the cutaneous HS microbiome.
#1Thomas Bjarnsholt (UCPH: University of Copenhagen)H-Index: 71
#2Henrik Calum (Hvidovre Hospital)H-Index: 10
#1Ida C. Thaarup (UCPH: University of Copenhagen)H-Index: 1
Last. Thomas Bjarnsholt (Copenhagen University Hospital)H-Index: 71
view all 3 authors...
Degradable starch microspheres (DSM) have long been used for topical haemostasis, temporary vascular occlusion and as drug delivery systems. When used for the latter, exact degradation rates of DSM have high importance, as this ensures a controlled and timed drug delivery. Current methods of analysing degradation rates are based on whole batch measurements, which does not yield information regarding individual times of degradation nor does it provide direct correlation measurements between spher...
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