John P. Neoptolemos
Heidelberg University
CancerInternal medicineEndocrinologySurgeryPathologyOncologyPancreatitisAcute pancreatitisChemotherapyPancreatic diseasePancreasDiseasePancreatic cancerGemcitabineCancer researchClinical trialGeneral surgeryMedicineBiologyGastroenterology
829Publications
125H-index
45.8kCitations
Publications 814
Newest
#1Marta SandiniH-Index: 15
#2Thilo HackertH-Index: 57
Last. John P. NeoptolemosH-Index: 125
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#1Pascal Probst (Heidelberg University)H-Index: 22
#2Felix J Hüttner (Heidelberg University)H-Index: 16
Last. Marco Del Chiaro (Anschutz Medical Campus)H-Index: 31
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BACKGROUND Pancreatic surgery is associated with considerable morbidity and, consequently, offers a large and complex field for research. To prioritize relevant future scientific projects, it is of utmost importance to identify existing evidence and uncover research gaps. Thus, the aim of this project was to create a systematic and living Evidence Map of Pancreatic Surgery. METHODS PubMed, the Cochrane Central Register of Controlled Trials, and Web of Science were systematically searched for all...
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#1Ryan Baron (RLUH: Royal Liverpool University Hospital)H-Index: 6
#2Andrea Sheel (RLUH: Royal Liverpool University Hospital)H-Index: 7
Last. John P. Neoptolemos (Heidelberg University)H-Index: 125
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Total pancreatectomy for severe pain in end-stage chronic pancreatitis may be the only option, but with vascular involvement, this is usually too high risk and/or technically not feasible. The purpose of the study was to present the clinical outcomes of a novel procedure in severe chronic pancreatitis complicated by uncontrollable pain and vascular involvement. We describe an in situ near-total pancreatectomy that avoids peripancreatic vascular dissection (Livocado procedure) and report on surgi...
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#1Christine Tjaden (University Hospital Heidelberg)H-Index: 12
#2Ulf HinzH-Index: 64
Last. Christoph BerchtoldH-Index: 5
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Objective null Evaluation of the outcome after resection for distal bile duct cancer (DBC) with focus on the impact of microscopic histopathological resection status R0 (>1 mm) vs R1 (≤1 mm) vs R1 (direct). null Summary background data null DBC is a rare disease for which oncologic resection offers the only chance of cure. null Methods null Prospectively collected data of consecutive patients undergoing pancreaticoduodenectomy for DBC were analyzed. Histopathological resection status was classif...
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#1Susanne Roth (University Hospital Heidelberg)H-Index: 11
#1Susanne Roth (University Hospital Heidelberg)H-Index: 1
Last. Thilo Hackert (University Hospital Heidelberg)H-Index: 57
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OBJECTIVE To propose a noninvasive diagnostic approach, which allows reliable distinction between low- and high-risk pancreatic intraductal papillary mucinous neoplasms (IPMNs). BACKGROUND IPMNs are identifiable precursor lesions of pancreatic cancer, of which surgical resection is warranted prior to the development of invasive carcinoma, but low-grade IPMNs should not be unnecessarily resected. However, diagnostic tools that preoperatively enable accurate risk stratification of IPMNs are missin...
1 CitationsSource
#1Markus K. Diener (Heidelberg University)H-Index: 48
#2André L. Mihaljevic (Heidelberg University)H-Index: 20
Last. Markus W. Büchler (Heidelberg University)H-Index: 173
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Abstract Background Modern pancreatic cancer surgery changed with the introduction of effective neoadjuvant therapies. Complete tumor resection is the mainstay for long-term, disease-free, and overall survival and has been a prerequisite for decreasing local recurrence. The medial resection margin in the area of the superior mesenteric vessels limits the radicalness of the resection, especially in borderline and locally advanced cases. Therefore, the periarterial soft tissue around the peripancr...
8 CitationsSource
#1Max Heckler (Heidelberg University)H-Index: 6
#2Thilo Hackert (Heidelberg University)H-Index: 5
Last. John P. Neoptolemos (Heidelberg University)H-Index: 125
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Acute pancreatitis (AP) is defined as an acute inflammatory attack of the pancreas of sudden onset. Around 25% of patients have either moderately severe or severe disease with a mortality rate of 15–20%. The aim of this article was to summarize the advances being made in the understanding of this disease and the important role of surgery. An accurate diagnosis should be made a soon as possible, initiating resuscitation with large volume intravenous fluids and oxygen by mask. Predicted severe dis...
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#1Manuel Gentiluomo (UniPi: University of Pisa)H-Index: 6
#2C. Corradi (UniPi: University of Pisa)H-Index: 1
Last. Gabriele Capurso (UniSR: Vita-Salute San Raffaele University)H-Index: 56
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Although pancreatic ductal adenocarcinoma (PDAC) survival is poor, there are differences in patients' response to the treatments. Detection of predictive biomarkers explaining these differences is of the utmost importance. In a recent study two genetic markers (CD44-rs353630 and CHI3L2-rs684559) were reported to be associated with survival after PDAC resection. We attempted to replicate the associations in 1856 PDAC patients (685 resected with stage I/II) from the PANcreatic Disease ReseArch (PA...
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#1Thomas Hank (University Hospital Heidelberg)H-Index: 11
#2Markus W. Büchler (University Hospital Heidelberg)H-Index: 173
Last. John P. Neoptolemos (University Hospital Heidelberg)H-Index: 125
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There is increasing interest in the use of adjuvant treatment for pancreatic cancer since although postoperative mortality is much improved, median long-term survival is only on the order of 11–15 mo. Despite a proliferation of studies in advanced pancreatic cancer indicating a benefit for chemotherapy, there has only been one small randomized adjuvant trial. A combination of 5-fluorouracil, doxorubicin, and mitomycin-C demonstrated a significantly improved median survival (23 vs 11 mo in contro...
3 CitationsSource
#1Fabian SchuhH-Index: 1
Last. Markus W. BüchlerH-Index: 173
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OBJECTIVE The aim of this study was to develop a classification system for pancreas-associated risk factors in pancreatoduodenectomy (PD). SUMMARY BACKGROUND DATA Postoperative pancreatic fistula (POPF) is the most relevant PD-associated complication. A simple standardized surgical reporting system based on pancreas- associated risk factors is lacking. METHODS A systematic literature search was conducted to identify studies investigating clinically relevant POPF (CR-POPF) and pancreas-associated...
1 CitationsSource