Lars Gullestad
Oslo University Hospital
Internal medicineCalcineurinEndocrinologySurgeryCardiologyRandomized controlled trialImmunologyPlaceboInflammationHeart failureCoronary artery diseaseCytokineHeart transplantationEverolimusPopulationTransplantationIn patientMyocardial infarctionMedicineEjection fraction
552Publications
82H-index
21.7kCitations
Publications 562
Newest
#1Muzammil Rafique (University of Oslo)H-Index: 1
#2Ole Geir Solberg (Oslo University Hospital)H-Index: 7
Last. Ketil Lunde (Oslo University Hospital)H-Index: 19
view all 10 authors...
Cardiac allograft vasculopathy (CAV) remains a leading cause of long-term mortality after heart transplantation. Both preventive measures and treatment options are limited. This study aimed to evaluate the short-term effects of high-intensity interval training (HIT) on CAV in de novo heart transplant (HTx) recipients as assessed by optical coherence tomography (OCT). The study population was a subgroup of the 81-patient HITTS study in which HTx recipients were randomized to HIT or moderate inten...
Source
#1Oskar Kristiansen (University of Oslo)H-Index: 1
#2Nils Tore Vethe (Oslo University Hospital)H-Index: 13
Last. John Munkhaugen (University of Oslo)H-Index: 10
view all 15 authors...
Aims To estimate the effect of atorvastatin on muscle symptom intensity in coronary heart disease (CHD) patients with self-perceived statin-associated muscle symptoms (SAMS) and to determine the relationship to blood levels of atorvastatin and/or metabolites. Methods and results A randomized multi-center trial consecutively identified 982 patients with previous or ongoing atorvastatin treatment after a CHD event. Of these, 97 (9.9%) reported SAMS and 77 were randomized to 7-weeks double-blinded ...
Source
#1A.H. Christensen (University of Oslo)H-Index: 1
#2S.I. Nygaard (University of Oslo)H-Index: 1
Last. Vegard Bruun Wyller (University of Oslo)H-Index: 22
view all 10 authors...
Abstract null null Background null Heart transplantation (HTx) surgically denervates the heart. We examined indices of sinoatrial reinnervation, with emphasis on 1) the occurrence and timing of parasympathetic reinnervation, and 2) the consequences of reinnervation for heart rate (HR) responsiveness and arterial baroreceptor sensitivity. null null null Methods null Fifty HTx recipients were prospectively followed for 36 months after surgery. Hemodynamic variables and heart rate variability were ...
Source
#1Jung-Min Ahn (Stanford University)H-Index: 1
#2Frederik M. Zimmermann (Stanford University)H-Index: 12
Last. William F. Fearon (VA Palo Alto Healthcare System)H-Index: 73
view all 19 authors...
Aims null We evaluated the long-term prognostic value of invasively assessing coronary physiology after heart transplantation in a large multicentre registry. null Methods and results null Comprehensive intracoronary physiology assessment measuring fractional flow reserve (FFR), the index of microcirculatory resistance (IMR), and coronary flow reserve (CFR) was performed in 254 patients at baseline (a median of 7.2 weeks) and in 240 patients at 1 year after transplantation (199 patients had both...
Source
#1Anne Pernille Ofstad (Boehringer Ingelheim)H-Index: 8
#2Odd Erik JohansenH-Index: 30
Last. Håvard Dalen (NTNU: Norwegian University of Science and Technology)H-Index: 31
view all 8 authors...
Source
#1M Rafique (Oslo University Hospital)
#2Ole Geir Solberg (Oslo University Hospital)H-Index: 7
Last. Ketil Lunde (Oslo University Hospital)H-Index: 19
view all 7 authors...
Source
#1Thor Ueland (Oslo University Hospital)H-Index: 85
#2Lars GullestadH-Index: 82
Last. Pål AukrustH-Index: 90
view all 11 authors...
We aimed to assess the value of GDF-15, a stress-responsive cytokine, in predicting clinical outcomes in patients with heart failure (HF) with reduced ejection fraction (HFrEF) and anemia Serum GDF-15 was assessed in 1582 HFrEF and mild-to-moderate anemia patients who where followed for 28 months in the Reduction of Events by Darbepoetin alfa in Heart Failure (RED-HF) trial, an overall neutral RCT evaluating the effect darbepoetin alfa on clinical outcomes in patients with systolic heart failure...
Source
#1Oscar Kristiansen (University of Oslo)H-Index: 1
#2Elise Sverre (University of Oslo)H-Index: 4
Last. Nils Tore Vethe (Oslo University Hospital)H-Index: 13
view all 11 authors...
BACKGROUND AND AIMS We aimed to determine the relationship between statin adherence measured directly, and by self-report measures and serum cholesterol levels. METHODS Patients prescribed atorvastatin (N = 373) participated in a cross-sectional study 2-36 months after a coronary event. Self-reported adherence included statin adherence the past week, the 8-item Morisky medication adherence scale (MMAS-8), and the Gehi et al. adherence question. Atorvastatin was measured directly in spot blood pl...
Source
#7Svend Aakhus (NTNU: Norwegian University of Science and Technology)H-Index: 6
Rationale Sleep apnea (SA) is highly prevalent in patients with atrial fibrillation (AF), and both conditions are associated with adverse cardiovascular outcomes. Objectives To determine the effect of continuous positive airway pressure (CPAP) on AF burden. Methods This open-label, parallel-group, randomized, controlled trial included patients with paroxysmal AF and moderate-to-severe SA (apnea-hypopnea index ≥15). Eligible patients were randomized (1:1) to 5 months' treatment with CPAP plus usu...
Source
#1Anders Haugom Christensen (University of Oslo)H-Index: 1
#2S.I. Nygaard (University of Oslo)H-Index: 1
Last. Vegard Bruun Wyller (University of Oslo)H-Index: 22
view all 10 authors...
Background Heart transplantation (HTx) surgically transects all connections to the heart, including the autonomic nerves. We prospectively examined signs, timing and consequences of early sympathetic and parasympathetic sinoatrial reinnervation, as well as explored indirect evidence of afferent cardiopulmonary reinnervation. Methods Fifty HTx recipients were assessed at 2.5, 6 and 12 months after HTx. For comparison, 50 healthy controls were examined once. Continuous, noninvasive recordings of h...
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.