Shadi A. Dayeh
University of California, San Diego
Electron mobilitySemiconductorEpitaxyMicroelectrodeField-effect transistorNanotechnologyTransistorElectrodeMaterials scienceCondensed matter physicsTransconductanceNanoscopic scaleOptoelectronicsSiliconGermaniumChemical vapor depositionDopingNucleationNanowireHeterojunction
185Publications
38H-index
7,521Citations
Publications 184
Newest
#1Youngbin TchoeH-Index: 10
#2Jihwan LeeH-Index: 3
Last. Shadi A. DayehH-Index: 38
view all 7 authors...
Nanoscale interfaces with biological tissue, principally made with nanowires (NWs), are envisioned as minimally destructive to the tissue and as scalable tools to directly transduce the electrochemical activity of a neuron at its finest resolution. This review lays the foundations for understanding the material and device considerations required to interrogate neuronal activity at the nanoscale. We first discuss the electrochemical nanoelectrode-neuron interfaces and then present new results con...
Source
#1Ren Liu (UCSD: University of California, San Diego)H-Index: 9
#2Jihwan Lee (UCSD: University of California, San Diego)H-Index: 3
Last. Shadi A. Dayeh (UCSD: University of California, San Diego)H-Index: 38
view all 19 authors...
Intracellular access with high spatiotemporal resolution can enhance our understanding of how neurons or cardiomyocytes regulate and orchestrate network activity, and how this activity can be affected with pharmacology or other interventional modalities. Nanoscale devices often employ electroporation to transiently permeate the cell membrane and record intracellular potentials, which tend to decrease rapidly to extracellular potential amplitudes with time. Here, we report innovative scalable, ve...
Source
#1Jimmy C. Yang (Harvard University)H-Index: 6
#2Angelique C. Paulk (Harvard University)H-Index: 19
Last. Jong Woo Lee (Brigham and Women's Hospital)H-Index: 21
view all 19 authors...
Abstract null null Objective null Interictal discharges (IIDs) and high frequency oscillations (HFOs) are established neurophysiologic biomarkers of epilepsy, while microseizures are less well studied. We used custom poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) microelectrodes to better understand these markers’ microscale spatial dynamics. null null null Methods null Electrodes with spatial resolution down to 50 µm were used to record intraoperatively in 30 subjects. IIDs’...
Source
#1Angelique C. Paulk (Harvard University)H-Index: 19
#2Jimmy C. Yang (Harvard University)H-Index: 6
Last. Sydney S. Cash (Harvard University)H-Index: 66
view all 43 authors...
Despite ongoing advances in our understanding of local single-cellular and network-level activity of neuronal populations in the human brain, extraordinarily little is known about their "intermediate" microscale local circuit dynamics. Here, we utilized ultra-high-density microelectrode arrays and a rare opportunity to perform intracranial recordings across multiple cortical areas in human participants to discover three distinct classes of cortical activity that are not locked to ongoing natural...
Source
#1Hongseok Oh (UCSD: University of California, San Diego)H-Index: 11
#2Shadi A. Dayeh (UCSD: University of California, San Diego)H-Index: 38
Source
#1Ritwik Vatsyayan (UCSD: University of California, San Diego)H-Index: 1
#2Daniel R. Cleary (UCSD: University of California, San Diego)H-Index: 13
Last. Shadi A. Dayeh (UCSD: University of California, San Diego)H-Index: 38
view all 5 authors...
Diagnostic and therapeutic electrical stimulation are increasingly utilized with the rise of neuromodulation devices. However, systematic investigations that depict the practical clinical stimulation paradigms (bipolar, 2-electrode configuration) to determine the safety limits are currently lacking. Further, safe charge densities that were classically determined from conical sharp electrodes are generalized for cylindrical (depth) and flat (surface grid) electrodes completely ignoring geometric ...
Source
We developed scalable manufacturing processes and dense connectorization to realize reconfigurable thin-film, multi-thousand channel neurophysiological recording grids using platinum-nanorods (PtNRGrids). PtNRGrids bridge the gap between increased spatial and temporal resolution and expanded cortical coverage. PtNRGrids resolved sub-millimeter functional organization of the barrel cortex in anesthetized rats that coincided well with histochemically demonstrated structure. In the clinical setting...
#1Lorraine Hossain (UCSD: University of California, San Diego)H-Index: 7
#2Martin Thunemann (BU: Boston University)H-Index: 17
Last. Anna Devor (BU: Boston University)H-Index: 38
view all 5 authors...
An ongoing effort in many neuroscience laboratories is to perform chronic optical imaging and multiplexed electrophysiological recordings in awake behaving mice. We have adapted the use of conformal thin parylene C in conjunction with conductive polymer PEDOT:PSS coating on the electrode sites to realize wearable microelectrode array devices with sufficient optical transparency to allow simultaneous multiphoton imaging and optogenetic manipulation. These devices replace the current cranial glass...
Source
#1Hongseok Oh (UCSD: University of California, San Diego)H-Index: 11
#2Gyu-Chul Yi (SNU: Seoul National University)H-Index: 70
Last. Shadi A. Dayeh (UCSD: University of California, San Diego)H-Index: 38
view all 4 authors...
We report large-scale and multiplexed tactile sensors with submillimeter-scale shear sensation and autonomous and real-time closed-loop grip adjustment. We leveraged dual-gate piezoelectric zinc oxide (ZnO) thin-film transistors (TFTs) fabricated on flexible substrates to record normal and shear forces with high sensitivity over a broad range of forces. An individual ZnO TFT can intrinsically sense, amplify, and multiplex force signals, allowing ease of scalability for multiplexing from hundreds...
Source
#1Sang Baek Ryu (Harvard University)H-Index: 8
#2Angelique C. Paulk (Harvard University)H-Index: 19
Last. Seung Woo LeeH-Index: 13
view all 8 authors...
OBJECTIVE Electrical stimulation via microelectrodes implanted in cortex has been suggested as a potential treatment for a wide range of neurological disorders. Despite some success however, the effectiveness of conventional electrodes remains limited, in part due to an inability to create specific patterns of neural activity around each electrode and in part due to challenges with maintaining a stable interface. The use of implantable micro-coils to magnetically stimulate the cortex has the pot...
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.