Katrien Lagrou
Katholieke Universiteit Leuven
EpidemiologyInternal medicinePathologyVirologyIntensive care medicineChemistryImmunologyIn vivoAspergillosisBronchoalveolar lavageDiseaseAspergillusAntifungalAspergillus fumigatusVoriconazoleGalactomannanTransplantationMedicineBiologyMicrobiologyGastroenterology
Publications 394
#1Ann-Sophie Jacob (Katholieke Universiteit Leuven)
#2Galai Chong (Erasmus University Medical Center)
Last. Stefanie Desmet (Katholieke Universiteit Leuven)H-Index: 13
view all 5 authors...
#1Laura HeiremanH-Index: 2
#2Steven Abrams (University of Antwerp)H-Index: 12
Last. Erwin HoH-Index: 3
view all 17 authors...
Introduction null The incidence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections in the Belgian community is mainly estimated based on test results of patients with coronavirus disease (COVID-19)-like symptoms. The aim of this study was to investigate the evolution of the SARS-CoV-2 reverse transcriptase polymerase chain reaction (RT-PCR) positivity ratio and distribution of viral loads within a cohort of asymptomatic patients screened prior hospitalization or surgery, ...
#1Mona KhanH-Index: 11
#2Seung-Jun YooH-Index: 1
Last. Lukas Marcelis (Katholieke Universiteit Leuven)H-Index: 7
view all 29 authors...
SUMMARY null Anosmia, the loss of smell, is a common and often the sole symptom of COVID-19. The onset of the sequence of pathobiological events leading to olfactory dysfunction remains obscure. Here, we have developed a postmortem bedside surgical procedure to harvest endoscopically samples of respiratory and olfactory mucosae and whole olfactory bulbs. Our cohort of 85 cases included COVID-19 patients who died a few days after infection with SARS-CoV-2, enabling us to catch the virus while it ...
#1Matthias Gijsen (Katholieke Universiteit Leuven)H-Index: 5
#2Britt Bekkers (Katholieke Universiteit Leuven)H-Index: 1
Last. Isabel Spriet (Katholieke Universiteit Leuven)H-Index: 29
view all 9 authors...
Cefepime is a first-line antibiotic for the treatment of febrile neutropenia (FN) in haematological cancer patients. Therapeutic drug monitoring (TDM) of cefepime is frequently advocated. However, it remains unclear what range of concentrations should be targeted for maximal efficacy and minimal toxicity. Therefore, we examined the relationship between cefepime exposure and clinical efficacy or neurotoxicity in FN patients. This prospective, observational, single-centre study included all adult ...
#1Robina Aerts (Katholieke Universiteit Leuven)H-Index: 1
#2Toine Mercier (Katholieke Universiteit Leuven)H-Index: 12
Last. Johan Maertens (Katholieke Universiteit Leuven)H-Index: 73
view all 6 authors...
Abstract null null Objectives null Prophylaxis with trimethoprim–sulphamethoxazole (TMP-SMZ) is recommended in Toxoplasma-seropositive allogeneic haematopoietic cell transplant (HCT) recipients to prevent reactivation, but it is associated with numerous side effects. We report our experience of a pre-emptive approach guided by a polymerase chain reaction (PCR) in patients not receiving prophylaxis. null null null Methods null In this retrospective, single-centre experience, seropositive recipien...
#1Ruth Van Daele (Katholieke Universiteit Leuven)H-Index: 4
#2Joost Wauters (Katholieke Universiteit Leuven)H-Index: 25
Last. Isabel Spriet (Katholieke Universiteit Leuven)H-Index: 29
view all 7 authors...
BACKGROUND Isavuconazole is a triazole antifungal drug, approved for the treatment of invasive aspergillosis and mucormycosis. It has been previously reported that an interaction between flucloxacillin and voriconazole may lead to subtherapeutic voriconazole exposure, when used concomitantly. Since isavuconazole is also metabolised via cytochrome P450 enzymes, the same interaction may be expected. OBJECTIVES We aim to document exposure to isavuconazole in patients concomitantly treated with fluc...
#1Charlotte Quintens (Katholieke Universiteit Leuven)H-Index: 4
#2Willy Peetermans (Katholieke Universiteit Leuven)H-Index: 46
Last. Isabel Spriet (Katholieke Universiteit Leuven)H-Index: 29
view all 8 authors...
Objectives null Inappropriate prescribing of antimicrobials in hospitals contributes to the emergence of resistance and adverse drug events. To support antimicrobial stewardship (AMS), clinical decision rules focusing on antimicrobial therapy were implemented in the 'Check of Medication Appropriateness' (CMA). The CMA is a hospital-wide pharmacist-led medication review service consisting of a clinical rule-based screening for potentially inappropriate prescriptions (PIPs). We aimed to investigat...
#1Lore Vanderbeke (Katholieke Universiteit Leuven)H-Index: 9
#2Katrien Lagrou (Katholieke Universiteit Leuven)H-Index: 58
Last. Joost Wauters (Katholieke Universiteit Leuven)H-Index: 25
view all 4 authors...
#1Ruth Van DaeleH-Index: 4
#2Joost Wauters (Katholieke Universiteit Leuven)H-Index: 25
Last. Isabel Spriet (Katholieke Universiteit Leuven)H-Index: 29
view all 9 authors...
Background: Fluconazole is one of the oldest antifungal drugs. Previous studies have raised concerns considering variability in exposure and inadequate target attainment in critically ill patients. The current study aims to define variability and target attainment for fluconazole exposure in a large group of critically ill patients. Methods: In this pharmacokinetic study, daily plasma trough samples and, if possible, 24 h urine samples were collected to determine fluconazole concentration. A min...
#1Rosalie SacheliH-Index: 8
#2Lize Cuypers (Katholieke Universiteit Leuven)H-Index: 10
Last. Marie-Pierre HayetteH-Index: 19
view all 7 authors...
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