Patrick Levallois
Laval University
EpidemiologyEnvironmental chemistryRisk assessmentRural areaPublic healthAnimal scienceOdds ratioTap waterChemistryExposure assessmentGeographyWater qualitySmall for gestational agePopulationDistribution systemEnvironmental exposureEnvironmental scienceMedicineBiologyEnvironmental health
117Publications
32H-index
3,300Citations
Publications 116
Newest
#1Mathieu Valcke (UdeM: Université de Montréal)H-Index: 12
Last. Patrick Levallois (Laval University)H-Index: 32
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Abstract The aim of this study was to assess the impact of exposure to tap water lead concentration ([Pb]TW) occurring in schools or daycares on blood lead level (BLL) of attending children. Given the potentially wide variations in space and time of ([Pb]TW) documented in the literature, a simple probabilistic toxicokinetic (STK) model that allows the simulation of the time-varying evolution of BLL in response to these variations was developed. Thus, basic toxicokinetic equations were assembled ...
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#1Christelle Legay (Laval University)H-Index: 8
#2Sylvie Leduc (Laval University)H-Index: 1
Last. Manuel J. Rodriguez (Laval University)H-Index: 52
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Abstract People are exposed to chlorinated by-products (CBPs) through the consumption of cold tap water (CTW) (ingestion, inhalation, dermal contact) but also through the use of hot tap water (HTW) in such activities as showering and bathing (inhalation, dermal contact). This study focuses on the impact of residential water heating on CBP levels in tap water. Trihalomethane (THM) and haloacetic acid (HAA) levels were measured in the CTW and HTW of 50 residences located in two distribution system...
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Manganese is a natural contaminant of water sources. It is an essential oligo-element, which may exert toxicity at high doses, particularly via inhalation. Its toxicity by the oral route is less known, but epidemiological and experimental studies tend to support its neurodevelopmental toxicity in infants and children. This paper describes the method used by a middle-size public health institution to derive a Drinking Water Guideline (DWG) for manganese. After reviewing the work done by major pub...
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#1Julien VachonH-Index: 3
#2Florence Pagé-Larivière (Laval University)H-Index: 4
Last. Céline Campagna (Laval University)H-Index: 10
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: Human health risk assessment (HHRA) must be adapted to the challenges of the 21st century, and the use of toxicogenomics data in HHRA is among the changes that regulatory agencies worldwide are trying to implement. However, the use of toxicogenomics data in HHRA is still limited. The purpose of this study was to explore the availability, quality, and relevance to HHRA of toxicogenomics publications as potential barriers to their use in HHRA. We conducted a scoping review of available toxicogen...
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#1Tarik Benmarhnia (UCSD: University of California, San Diego)H-Index: 20
#2Ianis Delpla (Laval University)H-Index: 10
Last. Patrick LevalloisH-Index: 32
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The epidemiological evidence demonstrating the effect of disinfection by-products (DBPs) from drinking water on colon and rectal cancers is well documented. However, no systematic assessment has been conducted to assess the potential effect measure modification (EMM) in the relationship between DBPs and cancer. The objective of this paper is to conduct a systematic literature review to determine the extent to which EMM has been assessed in the relationship between DBPs in drinking water in past ...
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#1Patrick Levallois (Laval University)H-Index: 32
#2Prabjit Barn (BC Centre for Disease Control)H-Index: 3
Last. Tom Kosatsky (BC Centre for Disease Control)H-Index: 29
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Purpose of Review Lead can enter drinking water from lead service lines and lead-containing plumbing, particularly in the presence of corrosive water. We review the current evidence on the role of drinking water as a source of lead exposure and its potential impacts on health, with an emphasis on children. Drinking water guidelines and mitigation strategies are also presented.
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#1Samuella G. Bonou (Laval University)H-Index: 1
#2Patrick Levallois (Laval University)H-Index: 32
Last. Alexandre Bureau (Laval University)H-Index: 22
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Abstract Genetic susceptibility may modulate chlorination by-products (CBPs) effects on fetal growth, especially genes coding for the cytochrome P450 involved in the metabolism of CBPs and steroidogenesis. In a case-control study of 1432 mother-child pairs, we assessed the association between maternal and child single nucleotide polymorphisms (SNPs) within CYP1A2, CYP2A6, CYP2D6 and CYP17A1 genes and small-for-gestational-age neonates (SGA Interactions were found between mother and neonate carry...
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#1Rochelle Garner (Statistics Canada)H-Index: 19
#2Patrick Levallois (Laval University)H-Index: 32
Abstract Background Cadmium has been inconsistently related to blood pressure and hypertension. The present study seeks to clarify the relationship between cadmium levels found in blood and urine, blood pressure and hypertension in a large sample of adults. Methods The study sample included participants ages 20 through 79 from multiple cycles of the Canadian Health Measures Survey (2007 through 2013) with measured blood cadmium (n=10,099) and urinary cadmium (n=6988). Linear regression models ex...
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#1Julien Vachon (Laval University)H-Index: 3
#2Céline Campagna (Laval University)H-Index: 10
Last. Patrick Levallois (Laval University)H-Index: 32
view all 5 authors...
Abstract Regulatory agencies worldwide need to modernize human health risk assessment (HHRA) to meet challenges of the 21st century. Toxicogenomics is at the core of this improvement. Today, however, the use of toxicogenomics data in HHRA is very limited. The purpose of this survey was to identify barriers to the application of toxicogenomics data in HHRA by human health risk assessors. An online survey targeting Canadian risk assessors gathered information on their knowledge and perception of t...
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