Chao Fang
Huazhong University of Science and Technology
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#1Yun Wang (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Jian-Hua Mao (SJTU: Shanghai Jiao Tong University)H-Index: 55
Last. Jin Wang (SJTU: Shanghai Jiao Tong University)H-Index: 28
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Platelet-targeted FVIII gene therapy can efficiently recover bleeding phenotype for hemophilia A (HA), yet characteristics of thrombus formation with this ectopic expression of factor VIII (FVIII) in platelets remain unclear. Here, we generated 2bF8trans mice restrictively expressing human B-domain–deleted FVIII (hBDD FVIII) in platelets on a hemophilic (FVIIInull) mice background. The results showed no statistical difference in clot strength and stability between wild-type (WT) and 2bF8trans mi...
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