Wei Shi
University of Macau
Publications 1
#1Yu-Chi Chen (UM: University of Macau)
#2Wei Shi (UM: University of Macau)
Last. Jin-Jian Lu (UM: University of Macau)H-Index: 41
view all 4 authors...
CD47, a transmembrane protein, acts as a "do not eat me" signal that is overexpressed in many tumor cell types, thereby forming a signaling axis with its ligand signal regulatory protein alpha (SIRPα) and enabling the tumor cells to escape from macrophage-mediated phagocytosis. Several clinical trials with CD47 targeting agents are underway and have achieved impressive results preliminarily. However, hematotoxicity (particularly anemia) has emerged as the most common side effect that cannot be n...
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