Minghua Zhuge
Zhejiang University
Visible spectrumBiophysicsMicroscopyRaman scatteringChemistryLipid dropletRetinoidMoleculeBiomoleculeChemical imaging
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#1Minghua Zhuge (ZJU: Zhejiang University)H-Index: 1
#1Minghua Zhuge (ZJU: Zhejiang University)H-Index: 1
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
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High-sensitivity chemical imaging offers a window to decipher the molecular orchestra inside a living system. Based on vibrational fingerprint signatures, coherent Raman scattering microscopy provides a label-free approach to map biomolecules and drug molecules inside a cell. Yet, by near-infrared (NIR) pulse excitation, the sensitivity is limited to millimolar concentration for endogenous biomolecules. Here, the imaging sensitivity of stimulated Raman scattering (SRS) is significantly boosted f...
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