E Demetriou
NeuriteNuclear Overhauser effectBiomedical engineeringWorld Wide WebChemical physicsNeuroscienceDispersion (optics)ChemistryMaterials scienceProtein foldingIn vivoCombinatorial chemistryNeurodegenerationDiseaseThalamusQuality (business)Acquisition SchemeSaturation transferChemical exchangePrion proteinCest mriCortex (botany)Computer scienceEngineering physicsComputational biologyBiologyOrientation (computer vision)
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In this work, we hypothesize that the metabolic changes occurring in the brain of prion-infected mice due to conformational changes of prion protein can be mapped using CEST MRI following previous in vivo work. Our previous findings include reduced Nuclear Overhauser Effect mediated by exchange-relayed signals in thalamus and cortex of prion-infected mice possibly related to up normal prion protein folding. Here we extend our studies by including a rich multipower acquisition scheme for targetin...
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1 Citations
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Last. H Zhang
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