Umadevi S Sajjan
Temple University
AirwayPhosphorylationInterleukin 33Internal medicineInnate immune systemUnfolded protein responseEndoplasmic reticulumAndrologyCD8ReceptorIntegrin alpha MChemistryAdverse effectImmunologyVirusPlaceboOxidative stressInterferonSTAT2COPDInflammationCystic fibrosisSTAT1LungMycobacterium tuberculosisAgonistRhinovirusCD11cComprehensive metabolic panelIRF3TuberculosisTLR2QuercetinPopulationEnergy metabolismCigarette smokingC57bl 6jReactive oxygen speciesCancer researchClinical trialSignal transductionMedicineProtein kinase BBiologyRespiratory epitheliumMicrobiologyGastroenterology
8Publications
2H-index
27Citations
Publications 9
Newest
#1Sudhir Kotnala (TU: Temple University)H-Index: 5
#2Yerin Kim (TU: Temple University)
Last. Umadevi S. Sajjan (TU: Temple University)H-Index: 31
view all 9 authors...
Dipeptidyl peptidase 4 (DPP4) expression is increased in the lungs of chronic obstructive pulmonary disease (COPD). DPP4 is known to be associated with inflammation in various organs, including LPS-induced acute lung inflammation. Since non-typeable Haemophilus influenzae (NTHi) causes acute exacerbations in COPD patients, we examined the contribution of DPP4 in NTHi-induced lung inflammation in COPD. Pulmonary macrophages isolated from COPD patients showed higher expression of DPP4 than the mac...
Source
#1Haleh Ganjian (TU: Temple University)H-Index: 1
#2Charu Rajput (TU: Temple University)H-Index: 1
Last. Umadevi S. Sajjan (TU: Temple University)H-Index: 31
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Airway epithelial cells, which lines the respiratory mucosa is in direct contact with the environment. Airway epithelial cells are the primary target for rhinovirus and other inhaled pathogens. In response to rhinovirus infection, airway epithelial cells mount both pro-inflammatory responses and antiviral innate immune responses to clear the virus efficiently. Some of the antiviral responses include the expression of IFNs, endoplasmic reticulum stress-induced unfolded protein response and autoph...
3 CitationsSource
#1MeiLan K. Han (UM: University of Michigan)H-Index: 74
#2Tyler A Barreto (TU: Temple University)H-Index: 1
Last. Umadevi S. Sajjan (TU: Temple University)H-Index: 31
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Introduction Quercetin is a plant flavonoid and has potent antioxidant and anti-inflammatory properties. In a preclinical model of chronic obstructive pulmonary disease (COPD), quercetin reduced markers of both oxidative stress and lung inflammation and also reduced rhinovirus-induced progression of lung disease. Although quercetin appears to be an attractive natural alternative to manage COPD, the safety of quercetin supplementation in this population is unknown. Methods We recruited COPD patie...
17 CitationsSource
#1Nathaniel Xander (TU: Temple University)H-Index: 3
#2Hymavathi Reddy Vari (TU: Temple University)H-Index: 2
Last. Umadevi S. Sajjan (TU: Temple University)H-Index: 31
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: IFN responses to viral infection are necessary to establish intrinsic antiviral state, but if unchecked can lead to heightened inflammation. Recently, we showed that TLR2 activation contributes to limitation of rhinovirus (RV)-induced IFN response in the airway epithelial cells. We also demonstrated that compared with normal airway epithelial cells, those from patients with chronic obstructive pulmonary disease (COPD) show higher IFN responses to RV, but the underlying mechanisms are not known...
9 CitationsSource
#1H. Reddyvari (TU: Temple University)
#2N. Xander (TU: Temple University)
Last. Umadevi S. Sajjan (TU: Temple University)H-Index: 31
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#1Joao Antonio Gimenes (TU: Temple University)H-Index: 2
#2V C Srivastava (TU: Temple University)H-Index: 4
Last. Umadevi S. Sajjan (TU: Temple University)H-Index: 31
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Rhinovirus (RV), which is associated with acute exacerbations, also causes persistent lung inflammation in patients with chronic obstructive pulmonary disease (COPD), but the underlying mechanisms are not well-known. Recently, we demonstrated that RV causes persistent lung inflammation with accumulation of a subset of macrophages (CD11b+/CD11c+), and CD8+ T cells, and progression of emphysema. In this study, we examined the mechanisms underlying the RV-induced persistent inflammation and progres...
3 CitationsSource
Source
#1Shawn E. SoutiereH-Index: 7
#2Wayne MitznerH-Index: 57
Last. Kristen J. WilkinsonH-Index: 6
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#1Adam T. ComstockH-Index: 18
#2Wai-Ming LeeH-Index: 1
Last. Andrea N. FarisH-Index: 8
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(MPA) and RV showed lowerlevelsofinterferons(IFNs)andhigherviralloadsthanthoseofRV-infectedcells.UnlikeresultsforCFcells,normalbronchial epithelial cells coinfected with MPA/RV showed higher IFN expression than RV-infected cells. In both CFand normal cells, the RV-stimulated IFN response requires phosphorylation of Akt and interferon response factor3 (IRF3). Preinfection with MPA inhibited RV-stimulated Akt phosphorylation and decreased IRF3 phosphoryla-tion in CF cells but not in normal cells. ...
1 Citations
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Adam T. Comstock
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Wuyan Li
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Shyamala Ganesan
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Kristen J. Wilkinson
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Marisa J. Linn
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Wayne Mitzner
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Mohammad Farazuddin
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Manal Elzoheiry
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Haleh Ganjian
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Charu Rajput
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Tyler A Barreto
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Rewees Eskandar
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Hymavathi Reddy Vari
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N. Xander
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H. Reddyvari
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Hymavathi Reddyvari
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Ying Zhao
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Rahul Mishra
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University of Michigan
Joao Antonio Gimenes
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Nathaniel Xander
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Sudhir Bolla
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Qiong Wang
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Rockefeller University
Wai-Ming Lee
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Shawn E. Soutiere
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Johns Hopkins University
Jeffrey L. Curtis
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Huifang Yang
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Nathaniel Marchetti
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