Meng Zhang
Boston University
Far-infrared laserMicroscopyInfraredWhole bloodRaman scatteringMinimum inhibitory concentrationPhotothermal therapyChemistryMaterials scienceIncubationPhotothermal effectUrineBroth microdilutionPhotobleachingOptoelectronicsAntibioticsBacteriaMetabolismChemical imagingMicroscopeMicrobiology
10Publications
1H-index
10Citations
Publications 10
Newest
#1Hongli NiH-Index: 1
#2Peng LinH-Index: 6
Last. Ji-Xin ChengH-Index: 83
view all 7 authors...
Spectroscopic stimulated Raman scattering (SRS) imaging has become a useful tool finding a broad range of applications. Yet, wider adoption is hindered by the bulky and environmentally-sensitive solid-state optical parametric oscillator (OPO) in current SRS microscope. Moreover, chemically-informative multi-window SRS imaging across C-H, C-D and fingerprint Raman regions is challenging due to the slow wavelength tuning speed of the solid-state OPO. In this work, we present a multi-window SRS ima...
#1Yi Zhang (BU: Boston University)H-Index: 4
#2Haonan Zong (BU: Boston University)H-Index: 2
Last. Ji-Xin ChengH-Index: 83
view all 7 authors...
Mid-infrared photothermal microscopy is a new chemical imaging technology in which a visible beam senses the photothermal effect induced by a pulsed infrared laser. This technology provides infrared spectroscopic information at submicrometer spatial resolution and enables infrared spectroscopy and imaging of living cells and organisms. Yet, current mid-infrared photothermal imaging sensitivity suffers from a weak dependence of scattering on the temperature, and the image quality is vulnerable to...
1 CitationsSource
#1Haonan ZongH-Index: 2
Last. Ji-Xin ChengH-Index: 83
view all 6 authors...
Mid-infrared photothermal (MIP) microscopy has been a promising label-free chemical imaging technique for functional characterization of specimens owing to its enhanced spatial resolution and high specificity. Recently developed wide-field MIP imaging modalities have drastically improved speed and enabled high-throughput imaging of micron-scale subjects. However, the weakly scattered signal from sub-wavelength particles becomes indistinguishable from the shot-noise as a consequence of the strong...
2 Citations
#1Yi ZhangH-Index: 4
#2Haonan ZongH-Index: 2
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 7 authors...
Mid-infrared photothermal microscopy is a new chemical imaging technology in which a visible beam senses the photothermal effect induced by a pulsed infrared laser. This technology provides infrared spectroscopic information at sub-micron spatial resolution and enables infrared spectroscopy and imaging of living cells and organisms. Yet, current mid-infrared photothermal imaging sensitivity suffers from a weak dependance of scattering on temperature and the image quality is vulnerable to the spe...
#1Haonan Zong (BU: Boston University)H-Index: 2
#2Celalettin Yurdakul (BU: Boston University)H-Index: 7
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 6 authors...
Mid-infrared photothermal microscopy (MIP) has been a promising chemical imaging technique for functionality characterization of biological and pharmaceutical specimens owing to its enhanced resolution and high-specificity. Recently developed wide-field MIP modalities drastically improved the imaging speed and thus enabled high-throughput imaging. However, the sensitivity of the wide-field MIP technique has been limited by shot-noise of background photons. Here, we demonstrate a dark-field MIP m...
Source
#1Yi Zhang (BU: Boston University)H-Index: 4
#2Zong Cheng (BU: Boston University)
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 5 authors...
Mid-infrared photothermal (MIP) imaging is an emerging technique where a visible beam is deployed to sense the photothermal lensing effect induced by infrared absorption of molecules. This technology provides sub-micron spatial resolution defined by the visible probe beam. Yet, the photothermal lensing effect is a weak effect for most materials. For instance, the diffraction coefficient of poly (methyl methacrylate) changes around 0.1% per Kelvin. Thus, highly sensitive probes are desired to imp...
Source
#1Cheng Zong (BU: Boston University)H-Index: 18
#2Yurun Xie (DICP: Dalian Institute of Chemical Physics)H-Index: 1
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 6 authors...
Plasmon-enhanced coherent Raman scattering microscopy has reached single-molecule detection sensitivity. Due to the different driven fields, there are significant differences between a coherent Raman scattering process and its plasmon-enhanced derivative. The commonly accepted line shapes for coherent anti-Stokes Raman scattering and stimulated Raman scattering do not hold for the plasmon-enhanced condition. Here, we present a theoretical model that describes the spectral line shapes in plasmon-...
2 CitationsSource
#1Pu-Ting Dong (BU: Boston University)H-Index: 6
#2Cheng Zong (BU: Boston University)H-Index: 18
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 9 authors...
Ergosterol-targeting amphotericin B (AmB) is the first line of defense for life-threatening fungal infections. Two models have been proposed to illustrate AmB assembly in the cell membrane; one is the classical ion channel model in which AmB vertically forms transmembrane tunnel and the other is a recently proposed sterol sponge model where AmB is laterally adsorbed onto the membrane surface. To address this controversy, we use polarization-sensitive stimulated Raman scattering from fingerprint ...
2 CitationsSource
#1Meng Zhang (BU: Boston University)H-Index: 1
#2Weili Hong (BU: Boston University)H-Index: 4
Last. Ji-Xin ChengH-Index: 83
view all 9 authors...
Rapid antimicrobial susceptibility testing (AST) is urgently needed for treating infections with appropriate antibiotics and slowing down the emergence of antibiotic-resistant bacteria. Here, a phenotypic platform that rapidly produces AST results by femtosecond stimulated Raman scattering imaging of deuterium oxide (D2O) metabolism is reported. Metabolic incorporation of D2O into biomass in a single bacterium and the metabolic response to antibiotics are probed in as short as 10 min after cultu...
14 CitationsSource
#1Meng ZhangH-Index: 15
#2Nader S. AbutalebH-Index: 11
Last. Ji-Xin ChengH-Index: 83
view all 9 authors...
Rapid antimicrobial susceptibility testing (AST) is urgently needed for treating infections with correct antibiotics and slowing down the emergence of antibiotic-resistant bacteria. Here, we report a phenotypic platform that rapidly produces AST results by femtosecond stimulated Raman scattering imaging of deuterium oxide (D2O) metabolism. Metabolic incorporation of D2O into biomass in a single bacterium is probed in as short as 10 minutes after culture in 70% D2O medium, the fastest among curre...
1 Citations