Kentaro Q. Sakamoto
University of Tokyo
Seasonal breederFGF21Insulin receptorAccelerationLoggingInternal medicineGeologyEngineeringEndocrinologyLeptin receptorWhite adipose tissueCardiologyForagingEndogenyAdipose tissueAdipose tissue macrophagesAeronauticsPredationField (physics)IRS2AcousticsSea turtleMeasure (physics)AdipocyteMarine mammalGrand ChallengesInsulin resistanceBradycardiaHyperplasiaWhaleGlucose uptakeHeart rateSeabirdGlucose clamp techniqueTachycardiaLeptinHyperinsulinemiaShell (structure)Adipocyte hypertrophyMeasure heart ratePseudorca crassidensGrampus griseusPower usageBattery capacityNon invasiveEnvironmental scienceFisheryDiabetes mellitusBird flightMedicineBiologySuction cup
Publications 7
#1Kagari Aoki (UTokyo: University of Tokyo)H-Index: 12
#2Yurie Watanabe (Whale Museum)H-Index: 1
Last. Kentaro Q. Sakamoto (UTokyo: University of Tokyo)H-Index: 16
view all 5 authors...
Heart rate monitoring in free-ranging cetaceans to understand their behavioural ecology and diving physiology is challenging. Here, we developed a simple, non-invasive method to monitor the heart rate of cetaceans in the field using an electrocardiogram-measuring device and a single suction cup equipped with an electrode. The unipolar suction cup was placed on the left lateral body surface behind the pectoral fin of Risso's dolphins (Grampus griseus) and a false killer whale (Pseudorca crassiden...
5 CitationsSource
To measure the heart rate of unrestrained sea turtles, it has been believed that a probe must be inserted inside the body owing to the presence of the shell. However, inserting the probe is invasive and difficult to apply to animals in the field. Here, we have developed a non-invasive heart rate measurement method for some species of sea turtles. In our approach, an electrocardiogram (ECG) was performed using an animal-borne ECG recorder and two electrodes-which were electrically insulated from ...
5 CitationsSource
#1Aran Garrod (UTokyo: University of Tokyo)
#2Sei Yamamoto (UTokyo: University of Tokyo)
Last. Katsufumi Sato (UTokyo: University of Tokyo)H-Index: 48
view all 4 authors...
The study of seabird behaviour has largely relied on animal-borne tags to gather information, requiring interpretation to estimate at-sea behaviours. Details of shallow-diving birds' foraging are less known than deep-diving species due to difficulty in identifying shallow dives from biologging devices. Development of smaller video loggers allow a direct view of these birds' behaviours, at the cost of short battery capacity. However, recordings from video loggers combined with relatively low powe...
#1Andreas FahlmanH-Index: 28
#2Kagari Aoki (UTokyo: University of Tokyo)H-Index: 12
Last. Danuta M. WisniewskaH-Index: 13
view all 15 authors...
4 CitationsSource
#1Nozomu Kamei (UTokyo: University of Tokyo)H-Index: 3
#2Kazuyuki TobeH-Index: 84
Last. Takashi KadowakiH-Index: 156
view all 24 authors...
Abstract Adipose tissue expression and circulating concentrations of monocyte chemoattractant protein-1 (MCP-1) correlate positively with adiposity. To ascertain the roles of MCP-1 overexpression in adipose, we generated transgenic mice by utilizing the adipocyte P2 (aP2) promoter (aP2-MCP-1 mice). These mice had higher plasma MCP-1 concentrations and increased macrophage accumulation in adipose tissues, as confirmed by immunochemical, flow cytometric, and gene expression analyses. Tumor necrosi...
719 CitationsSource
#1Ryo Suzuki (UTokyo: University of Tokyo)H-Index: 20
#2Kazuyuki TobeH-Index: 84
Last. Takashi KadowakiH-Index: 156
view all 15 authors...
Abstract Acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes catalyze the final step in mammalian triglyceride synthesis, and their functions are considered to be involved in the mechanisms of obesity, insulin resistance, and leptin resistance. Insulin receptor substrate-2 (IRS-2)-deficient mice exhibit obesity-associated with hypertrophic adipocytes and leptin resistance. Screening for transcripts of genes involved in fatty acid and triglyceride synthesis to investigate the mechanism of the ...
52 CitationsSource
#1Ryo Suzuki (UTokyo: University of Tokyo)H-Index: 20
#2Kazuyuki TobeH-Index: 84
Last. Takashi KadowakiH-Index: 156
view all 16 authors...
Abstract We previously reported that insulin receptor substrate-2 (IRS-2)-deficient mice develop diabetes as a result of insulin resistance in the liver and failure of β-cell hyperplasia. In this study we introduced the IRS-2 gene specifically into the liver of Irs2–/– mice with adenovirus vectors. Glucose tolerance tests revealed that the IRS-2 restoration in the liver ameliorated the hyperglycemia, but the improvement in hyperinsulinemia was only partial. Endogenous glucose production (EGP) an...
53 CitationsSource