Anil Kumar Kalvala
NephrotoxicityOxidative stressFisetinCisplatinNADPH oxidaseI?BaNOX4Respiratory enzymeBiochemistryBiologyPharmacology
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#1Bidya Dhar Sahu (Indian Institute of Chemical Technology)H-Index: 16
#2Anil Kumar KalvalaH-Index: 1
Last. Ramakrishna Sistla (Indian Institute of Chemical Technology)H-Index: 32
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Nephrotoxicity is a dose-dependent side effect of cisplatin limiting its clinical usage in the field of cancer chemotherapy. Fisetin is a bioactive flavonoid with recognized antioxidant and anti-inflammatory properties. In the present study, we investigated the potential renoprotective effect and underlying mechanism of fisetin using rat model of cisplatin-induced nephrotoxicity. The elevation in serum biomarkers of renal damage (blood urea nitrogen and creatinine); degree of histopathological a...
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