Neera Tewari-Singh
Michigan State University
Chemical warfareDNA damagePolitical scienceTumor necrosis factor alphaPoly ADP ribose polymeraseChemistryTerrorismIn vivoEx vivoMMP9Mechanism of actionOxidative stressEye injuriesCorneaInflammationBenzo(a)pyreneNettle agentChemical terrorismPhosgene oximeWound healingSulfur mustardLipid peroxidationMass CasualtyTissue PreservationChemical InjuryChemical Warfare AgentsMast cell activationProtein CarbonylationToxicityChemical exposureDermal exposureProgrammed cell deathCancer researchEpitheliumViability assayOxidative phosphorylationSignal transductionMedicineCriminologyPollutantMicrobiologyMechanism (biology)Cell biologyPharmacology
9Publications
1H-index
5Citations
Publications 9
Newest
#1Satyendra K. Singh (MSU: Michigan State University)H-Index: 9
#2Dinesh G Goswami (Anschutz Medical Campus)H-Index: 8
Last. Kathryn PateH-Index: 1
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Abstract null null With a possibility for the use of chemical weapons in battlefield or in terrorist activities, effective therapies against the devastating ocular injuries, from their exposure, are needed. Oxygen plays a vital role in ocular tissue preservation and wound repair. We tested the efficacy of supersaturated oxygen emulsion (SSOE) in reducing ex vivo corneal and keratocyte injury from chloropicrin (CP). CP, currently used as a pesticide, is a chemical threat agent like the vesicating...
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#6Neera Tewari-Singh (MSU: Michigan State University)H-Index: 1
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#1Satyendra K. Singh (MSU: Michigan State University)H-Index: 9
#1Satyendra Kumar Singh (MSU: Michigan State University)
Last. Neera Tewari-Singh (MSU: Michigan State University)H-Index: 1
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Highly toxic industrial chemicals that are widely accessible, and hazardous chemicals like phosgene oxime (CX) that can be easily synthesized, pose a serious threat as potential chemical weapons. In addition, their accidental release can lead to chemical emergencies and mass casualties. CX, an urticant, or nettle agent, grouped with vesicating agents, causes instant pain, injury and systemic effects, which can lead to mortality. With faster cutaneous penetration, corrosive properties, and more p...
1 CitationsSource
#1Swati Sharma (MSU: Michigan State University)
#2Joshua A. Klein (MSU: Michigan State University)H-Index: 1
Last. Neera Tewari-Singh (MSU: Michigan State University)H-Index: 1
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#1Robert P. CasillasH-Index: 20
#2Neera Tewari-Singh (MSU: Michigan State University)H-Index: 1
Last. Joshua P. Gray (United States Coast Guard Academy)H-Index: 19
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Chemical exposure emergencies posing a serious threat to the health and survival of civilians can be caused by terrorism events or industrial accidents. The National Institutes of Health (NIH) deve...
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#1Dinesh G Goswami (Anschutz Medical Campus)H-Index: 8
#2Rama Kant (Anschutz Medical Campus)H-Index: 8
Last. Neera Tewari-Singh (Anschutz Medical Campus)H-Index: 1
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ABSTRACT Chloropicrin (CP), a warfare agent now majorly used as a soil pesticide, is a strong irritating and lacrimating compound with devastating toxic effects. To elucidate the mechanism of its ocular toxicity, toxic effects of CP (0-100 µM) were studied in primary human corneal epithelial (HCE) cells. CP exposure resulted in reduced HCE cell viability and increased apoptotic cell death with an up-regulation of cleaved caspase 3 and poly ADP ribose polymerase indicating their contribution in C...
3 CitationsSource
#1Satyendra K. Singh (MSU: Michigan State University)H-Index: 9
#1Satyendra Kumar Singh (MSU: Michigan State University)
Last. Neera Tewari-Singh (MSU: Michigan State University)H-Index: 1
view all 6 authors...
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#1Joshua A. Klein (MSU: Michigan State University)H-Index: 1
#2Satyendra K. Singh (MSU: Michigan State University)H-Index: 9
Last. Neera Tewari-Singh (MSU: Michigan State University)H-Index: 1
view all 8 authors...
Source
#1Kathryn PateH-Index: 1
#2Dinesh G Goswami (Anschutz Medical Campus)H-Index: 8
Last. Neera Tewari-Singh (MSU: Michigan State University)H-Index: 1
view all 7 authors...
INTRODUCTION: Roughly 13% of all battlefield injuries include some form of ocular trauma. Ocular tissue preservation is critical for wound healing for warfighters with ocular injuries. Our team hypothesized that oxygen plays a vital role in ocular tissue preservation and wound healing and has developed a supersaturated oxygen emulsion (SOE) for the topical treatment of ocular trauma. MATERIALS AND METHODS: The partial pressure of oxygen (PO2) was measured in the SOE. Safety and efficacy studies ...
1 CitationsSource