Alexander Fisher
Canberra Hospital
Vitamin D and neurologyInternal medicineEndocrinologySurgeryRenal functionCardiologyBone remodelingIntensive care medicineMortality ratePhysical therapyProspective cohort studyHyperparathyroidismOsteoporosisAdiponectinCoronary artery diseaseSecondary hyperparathyroidismHip fractureDementiavitamin D deficiencyResistinCreatinineLeptinParathyroid hormoneAustralian capitalIncidence (epidemiology)StrokeDiabetes mellitusOrthopedic surgeryMedicineGerontologyBlood pressureGastroenterology
20Publications
12H-index
431Citations
Publications 20
Newest
#1Alexander Fisher (Canberra Hospital)H-Index: 12
#1Alexander Fisher (ANU: Australian National University)H-Index: 12
Last. Paul N. Smith (ANU: Australian National University)H-Index: 36
view all 4 authors...
Abstract Introduction The data on predictive value of the routinely obtained preoperative biochemical parameters in hip fracture (HF) patients are limited. The aims of this study were to examine in older HF patients (1) the relationships between a broad set of routine laboratory parameters at admission and in-hospital mortality, and (2) evaluate the prognostic value the biomarkers and clinical characteristics (alone or in combination) provide to predict a fatal outcome. Patients and methods In 1...
11 CitationsSource
#1Leon Fisher (Frankston Hospital)H-Index: 4
#2Alexander Fisher (Canberra Hospital)H-Index: 12
Last. Alexander Fisher (ANU: Australian National University)H-Index: 12
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This narrative review summarises the benefits, risks and appropriate use of acid-suppressing drugs (ASDs), proton pump inhibitors and histamine-2 receptor antagonists, advocating a rationale balanced and individualised approach aimed to minimise any serious adverse consequences. It focuses on current controversies on the potential of ASDs to contribute to infections—bacterial, parasitic, fungal, protozoan and viral, particularly in the elderly, comprehensively and critically discusses the growin...
13 CitationsSource
#1Alexander Fisher (ANU: Australian National University)H-Index: 12
#1Alexander Fisher (ANU: Australian National University)H-Index: 12
Last. Paul J. Smith (ANU: Australian National University)H-Index: 12
view all 4 authors...
Aim: To investigate the association of the neutrophil to lymphocyte ratio (NLR) at admission with presence of fracture, comorbid conditions, and its prognostic value for short-term outcomes in orthogeriatric patients. Methods: On 415 consecutive patients (mean age 78.8 ±8.7[SD] years, 281 women, 255 with a non-vertebral bone fracture, including 167 with a hip fracture, HF) admitted to the Department of Orthopaedic Surgery at the Canberra hospital (2010 - 2011) data on clinical and laboratory cha...
17 CitationsSource
#1Leon Fisher (Canberra Hospital)H-Index: 4
#2Wichat Srikusalanukul (Canberra Hospital)H-Index: 9
Last. Paul J. SmithH-Index: 12
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Aim: To asses liver markers in older patients with hip fracture (HF) in relation to age, comorbidities, metabolic characteristics and short-term outcomes. Methods: In 294 patients with HF (mean age 82.0±7.9 years, 72.1% women) serum alanine aminotransferase (ALT), gammaglutamyltransferase (GGT), alkaline phosphatase (ALP), albumin, bilirubin, 25(OH)vitaminD, PTH, calcium, phosphate, magnesium, adiponectin, leptin, resistin, thyroid function and cardiac troponin I were measured. Results: Elevated...
8 CitationsSource
#1Alexander Fisher (Canberra Hospital)H-Index: 12
#1Alexander Fisher (ANU: Australian National University)H-Index: 12
Last. Michael Davis (ANU: Australian National University)H-Index: 11
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Aims The objective of this study is (i) to evaluate trends in the incidence rates of stroke survivors aged 60 years and older over a 11-year period in the Australian Capital Territory (ACT) and (ii) to forecast future trends in Australia until 2051. Methods Analysis of age- and sex-specific standardized incidence rates of older first-ever stroke survivors in ACT from 1999-2000 to 2009-2010 and projections of number of stroke survivors (NSS) in 2021 and 2051 using 2 models based only on (i) demog...
13 CitationsSource
#1Alexander Fisher (Canberra Hospital)H-Index: 12
#1Alexander Fisher (ANU: Australian National University)H-Index: 12
Last. Paul J. Smith (ANU: Australian National University)H-Index: 12
view all 4 authors...
Objective. To assess the prevalence, clinical and laboratory characteristics, and short-term outcomes of poststroke hip fracture (HF). Methods. A cross-sectional study of 761 consecutive patients aged ≥60 years ( years; 75% females) with osteoporotic HF. Results. The prevalence of poststroke HF was 13.1% occurring on average 2.4 years after the stroke. The poststroke group compared to the rest of the cohort had a higher proportion of women, subjects with dementia, history of TIA, hypertension, c...
19 CitationsSource
#1Alexander Fisher (ANU: Australian National University)H-Index: 12
#1Alexander Fisher (ANU: Australian National University)H-Index: 12
Last. Paul N. Smith (ANU: Australian National University)H-Index: 36
view all 4 authors...
Background Data on clinical characteristics and outcomes in regard to hip fracture (HF) type are controversial. This study aimed to evaluate whether clinical and laboratory predictors of poorer outcomes differ by HF type.
19 CitationsSource
#1Alexander Fisher (ANU: Australian National University)H-Index: 12
#1Alexander Fisher (Canberra Hospital)H-Index: 12
Last. Paul J. Smith (ANU: Australian National University)H-Index: 12
view all 6 authors...
Abstract Objectives To determine the relationship of serum resistin concentrations to biochemical determinants of bone metabolism, comorbidity and outcomes in patients with hip fracture (HF). Methods In 256 consecutive patients (mean age 81.9 ± 7.8 years; 71.1% women) serum levels of resistin (determined by ELISA), biochemical parameters of bone turnover and mineral metabolism as well as routine haematological and biochemical parameters were measured. Clinical data were recorded prospectively. R...
14 CitationsSource
#1Alexander A. Fisher (Canberra Hospital)H-Index: 20
#1Alexander Fisher (Canberra Hospital)H-Index: 12
Last. Paul J. Smith (ANU: Australian National University)H-Index: 12
view all 4 authors...
Abstract Objective To investigate whether clinical and laboratory characteristics, including serum 25-hydroxyvitamin D (25(OH) D), PTH and parameters of mineral and bone metabolism, differ by hip fracture (HF) type. Patients and methods We studied prospectively 761 consecutively admitted older patients (mean age 82.3 + 8.8(SD) years; 74.9% women) with low trauma non-pathological HF. A detailed clinical examination was performed, haematologic, renal, liver and thyroid function tests, serum 25(OH)...
32 CitationsSource
#1Alexander Fisher (ANU: Australian National University)H-Index: 12
#1Alexander Fisher (Canberra Hospital)H-Index: 12
Last. Michael W Davis (ANU: Australian National University)H-Index: 7
view all 4 authors...
To determine whether serum 25(OH)D and/or PTH levels in older patients with hip fracture (HF) could predict short-term clinical outcomes, we conducted a prospective observational study of 287 consecutive HF patients (mean age 81.9 ± 7.5 [SD] years, 72% females). The prevalence of vitamin D inadequacy (25[OH]D 6.8 pmol/l) was 35.5%. After adjustment for age and sex, PTH was significantly associated with in-hospital mortality (OR = 1.12, 95% CI 10.5–1.20, P < 0.001), myocardial injury (OR = 1.05, ...
37 CitationsSource