Lourdes A Esparza
University of California, San Diego
ExomeCancerEpigenomicsInternal medicineDownregulation and upregulationEndocrinologyOncologyDynorphinCitric acid cycleReceptorCarbohydrate metabolismGene expression profilingChemistryDNA methylationGonadotropic cellGlycolysisIn vivoLactic acidKisspeptinHypothalamusEstrogenOvulationAndrogenArcuate nucleusLuteinizing hormoneGonadotropinMetastasisDiseaseOrphan receptorGlutamineDihydrotestosteronePancreatic cancerMedulloblastomaAnovulationAdenocarcinomaNeurokinin BRegimenStem cellPopulationAndrogen secretionPuberty onsetPolycystic ovaryLh secretionCancer researchAmino acidTestosteroneCancer stem cellBiochemistryCarcinogenesisBioinformaticsAndrogen receptorMetabolismRNAMedicinePulsatile flowBiologyQuantitative analysis (chemistry)
8Publications
3H-index
553Citations
Publications 9
Newest
#1Margaret A. Mohr (UCLA: University of California, Los Angeles)H-Index: 9
#2Lourdes A Esparza (UCSD: University of California, San Diego)H-Index: 3
Last. Alexander S. Kauffman (UCSD: University of California, San Diego)H-Index: 37
view all 5 authors...
Kisspeptin, encoded by Kiss1, stimulates gonadotropin-releasing hormone neurons to govern reproduction. In female rodents, estrogen-sensitive kisspeptin neurons in the rostral anteroventral periventricular (AVPV) hypothalamus are thought to mediate estradiol (E2)-induced positive feedback induction of the preovulatory luteinizing hormone (LH) surge. AVPV kisspeptin neurons coexpress estrogen and progesterone receptors (PGRs) and are activated during the LH surge. While E2 effects on kisspeptin n...
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#1Eulalia A Coutinho (UCSD: University of California, San Diego)H-Index: 1
#2Lourdes A. Esparza (UCSD: University of California, San Diego)H-Index: 7
Last. Alexander S. Kauffman (UCSD: University of California, San Diego)H-Index: 37
view all 5 authors...
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#1Lourdes A Esparza (UCSD: University of California, San Diego)H-Index: 3
#1Lourdes A. Esparza (UCSD: University of California, San Diego)H-Index: 7
Last. Alexander S. Kauffman (UCSD: University of California, San Diego)H-Index: 37
view all 4 authors...
Androgens can affect the reproductive axis of both sexes. In healthy women, as in men, elevated exogenous androgens decrease gonad function and lower gonadotropin levels; such circumstances occur with anabolic steroid abuse or in transgender men (genetic XX individuals) taking androgen supplements. The neuroendocrine mechanisms by which endogenous or exogenous androgens regulate gonadotropin release, including aspects of pulsatile luteinizing hormone (LH) secretion, remain unknown. Because anima...
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#1Eulalia A Coutinho (UCSD: University of California, San Diego)H-Index: 1
#2Lourdes A. Esparza (UCSD: University of California, San Diego)H-Index: 7
Last. Alexander S. Kauffman (UCSD: University of California, San Diego)H-Index: 37
view all 4 authors...
Source
#1Lourdes A Esparza (UCSD: University of California, San Diego)H-Index: 3
#1Lourdes A. Esparza (UCSD: University of California, San Diego)H-Index: 7
Last. Alexander S. Kauffman (UCSD: University of California, San Diego)H-Index: 37
view all 5 authors...
Source
#1Lourdes A Esparza (UCSD: University of California, San Diego)H-Index: 3
#1Lourdes A. Esparza (UCSD: University of California, San Diego)H-Index: 7
Last. Alexander S. Kauffman (UCSD: University of California, San Diego)H-Index: 37
view all 5 authors...
Polycystic ovary syndrome (PCOS), a common reproductive disorder in women, is characterized by hyperandrogenemia, chronic anovulation, cystic ovarian follicles, and luteinizing hormone (LH) hyper-pulsatility, but the pathophysiology isn't completely understood. We recently reported a novel mouse model of PCOS using chronic letrozole (LET; aromatase inhibitor). Letrozole-treated females demonstrate multiple PCOS-like phenotypes, including polycystic ovaries, anovulation, and elevated circulating ...
10 CitationsSource
#1Nikki K. Lytle (UCSD: University of California, San Diego)H-Index: 15
#2L. Paige Ferguson (UCSD: University of California, San Diego)H-Index: 2
Last. Tannishtha ReyaH-Index: 39
view all 33 authors...
Summary Drug resistance and relapse remain key challenges in pancreatic cancer. Here, we have used RNA sequencing (RNA-seq), chromatin immunoprecipitation (ChIP)-seq, and genome-wide CRISPR analysis to map the molecular dependencies of pancreatic cancer stem cells, highly therapy-resistant cells that preferentially drive tumorigenesis and progression. This integrated genomic approach revealed an unexpected utilization of immuno-regulatory signals by pancreatic cancer epithelial cells. In particu...
39 CitationsSource
#1Sheng Hui (Princeton University)H-Index: 12
#2Jonathan M. Ghergurovich (Princeton University)H-Index: 11
Last. Joshua D. RabinowitzH-Index: 100
view all 12 authors...
Metabolic flux analysis in mice reveals that lactate often acts as the primary carbon source for the tricarboxylic acid cycle both in normal tissues and in tumour microenvironments.
522 CitationsSource
#1Jessica M. Rusert (DI: Discovery Institute)H-Index: 9
#2Alexandra Garancher (DI: Discovery Institute)H-Index: 11
Last. Robert J. Wechsler-Reya (DI: Discovery Institute)H-Index: 51
view all 18 authors...
Medulloblastoma (MB) is the most common malignant brain tumor in children. Even with an intensive regimen of surgery, radiation and chemotherapy, one-third of patients still die from their disease. Moreover, survivors suffer devastating side effects including cognitive deficits, endocrine disorders and an increased incidence of secondary cancers later in life. Thus, more effective and less toxic therapies are desperately needed. Recent genomic analyses have identified 4 major subgroups of MB—WNT...
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