Peng Zhang
University of Electronic Science and Technology of China
Downregulation and upregulationWnt signaling pathwayEmbryonic stem cellEndogenyGene knockdownSignal transductionTranscription factorBiologyEmbryogenesisCell biology
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#1Yuanshu Liu (MOE: Chinese Ministry of Education)H-Index: 1
#2Peng Zhang (University of Electronic Science and Technology of China)
Last. Rui Zhou (Boston Children's Hospital)
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Background and Objectives Manipulating different signaling pathways via small molecules could efficiently induce cardiomyocytes from human induced pluripotent stem cells (hiPSC). However, the effect of transcription factors on the hiPSC-directed cardiomyocytes differentiation remains unclear. Transcription factor, p53 has been demonstrated indispensable for the early embryonic development and mesendodermal differentiation of embryonic stem cells (ESC). We tested the hypothesis that p53 promotes ...
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