Al-Amin M
University of Padua
Translation (biology)ChemistryRhodopsinEx vivoEthylene glycolDrugRetinalRetinal degenerationChaperone (protein)Cell biology
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Publications 2
Newest
#1Merve Sen (University of Tübingen)H-Index: 2
#2Al-Amin (UNIPD: University of Padua)H-Index: 1
Last. Marius Ueffing (University of Tübingen)H-Index: 72
view all 10 authors...
Abstract null null Mutations in rhodopsin lead to its misfolding resulting in autosomal dominant retinitis pigmentosa (adRP). Pharmacological inhibition of the ATP-driven chaperone valosin-containing protein (VCP), a molecular checkpoint for protein quality control, slows down retinal degeneration in animal models. However, poor water-solubility of VCP inhibitors poses a challenge to their clinical translation as intravitreal injections for retinal treatment. In order to enable the delivery of V...
Source
#1Merve Sen (University of Tübingen)H-Index: 2
#2Al-Amin M (UNIPD: University of Padua)
Last. Marius Ueffing (University of Tübingen)H-Index: 72
view all 10 authors...
1.Mutations in rhodopsin lead to its misfolding resulting in autosomal dominant retinitis pigmentosa (adRP). Pharmacological inhibition of the ATP-driven chaperone valosin- containing protein (VCP), a molecular checkpoint for protein quality control, slows down retinal degeneration in animal models. However, poor water-solubility of VCP inhibitors poses a challenge to their clinical translation as intravitreal injections for retinal treatment. In order to enable the delivery of VCP inhibitors, w...
Source