Neng Wang
Guangzhou University of Chinese Medicine
10Publications
5H-index
69Citations
Publications 19
Newest
#1Jing Li (Guangzhou University of Chinese Medicine)H-Index: 1
#2Shengqi Wang (Guangzhou University of Chinese Medicine)H-Index: 14
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#9Neng Wang (Guangzhou University of Chinese Medicine)H-Index: 5
Abstract null null Background null : Metastasis is the most common lethal cause of breast cancer-related death. Recent studies have implied that autophagy is closely implicated in cancer metastasis. Therefore, it is of great significance to explore autophagy-related molecular targets involved in breast cancer metastasis and to develop therapeutic drugs null null null . Purpose null : This study was designed to investigate the anti-metastatic effects and autophagy regulatory mechanisms of the Aid...
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#3Neng Wang (Guangzhou University of Chinese Medicine)H-Index: 5
Background null Metastasis represents the leading cause of death in patients with breast cancer. Traditional Chinese medicine is particularly appreciated for metastatic diseases in Asian countries due to its benefits for survival period prolongation and immune balance modulation. However, the underlying molecular mechanisms remain largely unknown. This study aimed to explore the antimetastatic effect and immunomodulatory function of a clinical formula Aiduqing (ADQ). null Methods null Naive CD4+...
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#10Zhiyu Wang (Guangzhou University of Chinese Medicine)
Background: Depression plays a significant role in mediating breast cancer recurrence and metastasis. However, a precise risk model is lacking to evaluate the potential effects of depression on breast cancer prognosis. In this study, we established a depression-related gene (DRG) signature that can predict overall survival (OS) and elucidated its correlation with pathological parameters and sensitivity to therapy in breast cancer. Methods: The model training and validation assays were based on t...
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#7Fengxue Zhang (Guangzhou University of Chinese Medicine)H-Index: 6
#8Neng Wang (Guangzhou University of Chinese Medicine)H-Index: 5
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#1Neng Wang (Guangzhou University of Chinese Medicine)H-Index: 5
As one of the most abundant immune cell populations in the tumor microenvironment (TME), tumor-associated macrophages (TAMs) play important roles in multiple solid malignancies, including breast cancer, prostate cancer, liver cancer, lung cancer, ovarian cancer, gastric cancer, pancreatic cancer, and colorectal cancer. TAMs could contribute to carcinogenesis, neoangiogenesis, immune-suppressive TME remodeling, cancer chemoresistance, recurrence, and metastasis. Therefore, reprogramming of the im...
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#1Neng Wang (Guangzhou University of Chinese Medicine)H-Index: 5
Sanguisorba officinalis L. (SA) is a common herb for cancer treatment in the clinic, particularly during the consolidation phase to prevent occurrence or metastasis. Nevertheless, there are limited studies reporting the molecular mechanisms about its anti-metastatic function. It is well demonstrated that autophagy is one of the critical mechanisms accounting for metastasis and anti-cancer pharmacological actions of Chinese herbs. On the threshold, the regulatory effects and molecular mechanisms ...
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#4Zhiyu Wang (Guangzhou University of Chinese Medicine)
Tumorigenesis are closely associated with the immune function of the human body. Immunotherapy has emerged as a novel and promising treatment strategy in multiple malignancies in the 21st century. Traditional Chinese medicine (TCM) has been extensively used for cancer treatment in China and surrounding countries for it exerts efficient therapeutic effects with few side effects. In recent years, studies have demonstrated that TCM plays a unique and reliable role in regulating tumor immunity. TCM ...
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#3Zhiyu Wang (Guangzhou University of Chinese Medicine)
Purpose: Development of autophagy inhibitors has important clinical significance in cancer therapies. We and others demonstrated that over-expression of Caveolin-1 (Cav1), which was the major scaffolding protein of caveolae, was associated with higher tumor stage, metastasis and worse prognosis in various carcinomas, particularly in breast cancer. Furthermore, we identified critical role of Cav1 in breast cancer metastasis via modulation of lysosomal function and autophagy. Based on the above, w...
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