Chenxia Jiang
Nantong University
Gene knockdownTranscriptional regulationTumor microenvironmentLung cancerImmunotherapyEpigeneticsMutationCancer researchBiologyImmune system
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#1Yu Zhao (Nantong University)H-Index: 11
#2Yuejiao Cao (Nantong University)H-Index: 2
Last. Xiaorong Zhou (Nantong University)H-Index: 5
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Loss of the B2M gene is associated with tumor immune escape and resistance to immunotherapy. However, genetic alterations of the B2M gene are rare. We performed an integrative analysis of the mutational and transcriptional profiles of large cohorts of non-small-cell lung cancer (NSCLC) patients and found that epigenetic downregulation of B2M is common. B2M-low tumors exhibit a suppressive immune microenvironment characterized by reduced infiltration of immune cells of various lineages; in B2M-hi...
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