Qiang Zhang
Sichuan University
Therapeutic effectDruggabilityProdrugTransporterBioavailabilityChemistryIn vivoDrugToxicityPharmacology
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#1Honglin Xiang (Sichuan University)
#2Qiang Zhang (Sichuan University)
Last. Ling Zhang (Sichuan University)H-Index: 9
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Currently, ischemic stroke is the leading cause of disability and death worldwide, and the performance of corresponding drugs is often unsatisfactory owing to the complex pathological processes and the impediment of the blood-brain barrier (BBB). Here, we employed various tertiary amino groups, including different linear, cyclic, and bimolecular drug structures, to modify 3-n-butylphthalide (NBP), a natural product used for ischemic stroke treatment, which has poor bioavailability, to generate a...
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