Meiyan Fan
Quenching (fluorescence)Molecular modelChemistryApoptosisStructure–activity relationshipChelationIn vitroCombinatorial chemistryMoietyColchicineIC50ThiazoleKojic acidAntifungalDrugCell cycleActive siteBiochemistryPharmacophoreComputational biologyStereochemistryDrug discoveryA549 cellTubulinTyrosinaseCancer cell
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Publications 4
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#1Guangcheng WangH-Index: 13
#2Meiyan FanH-Index: 1
Last. Zhiyun Peng (Shanghai Ocean University)H-Index: 4
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A new series of sulphonamide derivatives bearing naphthalene moiety were synthesised and evaluated for their antiproliferative and tubulin polymerisation inhibitory activities. These new compounds ...
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#1Min HeH-Index: 1
#2Meiyan FanH-Index: 1
Last. Guangcheng Wang (MOE: Chinese Ministry of Education)
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Abstract Hydroxypyranone and hydroxypyridinone are important oxygen-containing or nitrogen-containing heterocyclic nucleus and attracted increasing attention in medicinal chemistry and drug discovery over the past decade. Previous literature reports revealed that hydroxypyranone and hydroxypyridinone derivatives exhibit a wide range of pharmacological activities such as antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, antioxidant, anticonvulsant, and anti-diabetic activities....
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#1Guangcheng WangH-Index: 13
#2Wenjing LiuH-Index: 4
Last. Zhiyun Peng (Shanghai Ocean University)H-Index: 4
view all 6 authors...
A novel series of thiazole-naphthalene derivatives as tubulin polymerisation inhibitors were designed, synthesised, and evaluated for the anti-proliferative activities. The majority of the tested compounds exhibited moderate to potent antiproliferative activity on the MCF-7 and A549 cancer cell lines. Among them, compound 5b was found to be the most active compound with IC50 values of 0.48 ± 0.03 and 0.97 ± 0.13 μM. Moreover, mechanistic studies revealed that 5b significantly inhibited tubulin p...
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Abstract null null Tyrosinase plays an important role in melanin biosynthesis and enzymatic browning of fresh-cut fruit and vegetables. To discover potent tyrosinase inhibitors and antibrowning agents, a series of novel kojic acid derivatives containing bioactive heterocycle moiety (4a-4l) were designed and synthesized. Thereinto, 4d displayed the most potent tyrosinase inhibitory activity with IC50 of 3.23 ± 0.26 μM and behaved as a competitive inhibitor with a Ki of 1.96 μM, compared to kojic ...
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