Sarah L. Mueller
Griffith University
IsozymeFragment-based lead discoveryChemistryCarbonic anhydraseThiazolidinedioneTroglitazonePioglitazoneRosiglitazoneZincBiochemistry
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The approved drugs that target carbonic anhydrases (CA, EC 4.2.1.1), a family of zinc metalloenzymes, comprise almost exclusively of primary sulfonamides (R-SO2NH2) as the zinc binding chemotype. New clinical applications for CA inhibitors, particularly for hard-to-treat cancers, has driven a growing interest in the development of novel CA inhibitors. We recently discovered that the thiazolidinedione heterocycle, where the ring nitrogen carries no substituent, is a new zinc binding group and an ...
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