Rita Businaro
Sapienza University of Rome
Internal medicineDownregulation and upregulationPhenotypeChemokineEndocrinologyMetabolomeCell migrationLRP1SurgeryCytoskeletonPathologyCell signalingInterleukin 23AntibodyAutoantibodyProinflammatory cytokineStromal cellReceptorAdipose tissueTelomereMucinChemistryCell typeExtracellular matrixIngestionProgenitor cellIn vitroImmunologyImmunohistochemistryHeat shock proteinPathologicalMultidisciplinary approachStimulationNeuroprotectionEx vivoHsp90Dry mouthOxidative stressBleomycinPlatelet lysateNicotinamide adenine dinucleotideInflammationNeurodegenerationInflammasomeSpinnbarkeitUmbilical veinMUC1LungAntioxidantPostprandialExocrine glandBlood–brain barrierKetogenic dietNitrogen mustardProtein APICALMDiseaseAnti-inflammatoryRAC1MicrogliaUrineWound healingAngiogenesisToxicantFibrosisMetabolic syndromeInvolution (medicine)OverweightSulfur mustardPathogenesisPulmonary fibrosisGlycemic loadGlucose Transporter Type 1Blueberry extractType 2 Diabetes MellitusPossible diagnosisActin cytoskeleton organizationCognitive impairmentLung injuryActin cytoskeletonKetone bodiesInterleukin 17Reactive oxygen speciesSecretionSalivaCentral nervous systemViability assayMedical diagnosisInterleukin 18MedicineNAD+ kinaseEpithelial–mesenchymal transitionBiologyNeuroinflammationAmyloidImmune systemNeuropeptide Y receptorCell biologyGerminal centerPharmacologyCaspase
15Publications
6H-index
120Citations
Publications 15
Newest
Background It is a common opinion that Primary Sjogren Syndrome (pSS) damages the exocrine glands and determines the reduction of secreted saliva, some studies show that there are qualitative anomalies of the mucins produced in saliva, including MUC7, MUC5B, MUC1. The purpose of this study is to trace all the information useful to establish whether there is a qualitative or quantitative defect of the mucins in the pSS. Material and methods We reviewed the literature by looking for publications r...
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#1Rama Malaviya (RU: Rutgers University)H-Index: 14
#2Howard M. Kipen (RU: Rutgers University)H-Index: 44
Last. Debra L. Laskin (RU: Rutgers University)H-Index: 72
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Abstract Pulmonary fibrosis is characterized by destruction and remodeling of the lung due to an accumulation of collagen and other extracellular matrix components in the tissue. This results in progressive irreversible decreases in lung capacity, impaired gas exchange and eventually, hypoxemia. A number of inhaled and systemic toxicants have been identified that cause pulmonary fibrosis including bleomycin, silica, asbestos, nanoparticles, mustard vesicants, nitrofurantoin, amiodarone, and ioni...
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#1Rita Businaro (Sapienza University of Rome)H-Index: 18
#1Rita Businaro (Sapienza University of Rome)H-Index: 6
Last. Debra L. Laskin (RU: Rutgers University)H-Index: 72
view all 5 authors...
Exposure to vesicants, including sulfur mustard and nitrogen mustard, causes damage to the epithelia of the respiratory tract and the lung. With time, this progresses to chronic disease, most notably, pulmonary fibrosis. The pathogenic process involves persistent inflammation and the release of cytotoxic oxidants, cytokines, chemokines, and profibrotic growth factors, which leads to the collapse of lung architecture, with fibrotic involution of the lung parenchyma. At present, there are no effec...
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#1Massimo Fusconi (Sapienza University of Rome)H-Index: 22
#2Isotta Musy (Sapienza University of Rome)H-Index: 1
Last. Rita Businaro (Sapienza University of Rome)H-Index: 6
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Abstract Objectives The diagnosis of primary Sjogren’s syndrome (pSS) continues to be difficult and several patients keep symptomatic for years with different diagnoses before confirmation of pSS. Since the IL-23-IL-17 axis is involved in the etiopathogenesis of pSS we evaluated by immunohistochemistry and morphometric methods the presence of IL-17 as well as IL-23 within minor salivary glands (MSG) obtained from patients with uncertain diagnosis of pSS. Materials and Methods 42 patients, with s...
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#1Daniela Scarabino (National Research Council)H-Index: 6
#2Martina Peconi (Sapienza University of Rome)H-Index: 3
Last. Rita Businaro (Sapienza University of Rome)H-Index: 6
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Abstract Inflammation plays a crucial role in Alzheimer's disease (AD). AD neurodegeneration and concurrent involvement of the peripheral immune system may promote leukocyte division and telomere shortening. We examined genotypes and plasma levels of two proinflammatory cytokines, IL-1beta and IL-18, and leukocyte telomere length (LTL) in patients with mild cognitive impairment (MCI) and AD. We wanted to determine whether changes in plasma IL-1beta and IL-18 levels, together with LTL shortening,...
3 CitationsSource
#1Maria Giovanna De Caris (Sapienza University of Rome)H-Index: 2
#2Maddalena Grieco (Sapienza University of Rome)H-Index: 2
Last. Rita Businaro (Sapienza University of Rome)H-Index: 6
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Microglia, the innate immune cells of the CNS, respond to brain injury by activating and modifying their morphology. Our study arises from the great interest that has been focused on blueberry (BB) for the antioxidant and pharmacological properties displayed by its components. We analyzed the influence of hydroalcoholic BB extract in resting or lipopolysaccharide (LPS)-stimulated microglia BV-2 cells. BB exerted a protective effect against LPS-induced cytotoxicity, as indicated by cell viability...
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#1Jaclynn Andres (RU: Rutgers University)H-Index: 1
#2Ley Cody Smith (RU: Rutgers University)H-Index: 3
Last. Debra L. Laskin (RU: Rutgers University)H-Index: 72
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Abstract Extracellular vesicles (EVs) have emerged as key regulators of cell-cell communication during inflammatory responses to lung injury induced by diverse pulmonary toxicants including cigarette smoke, air pollutants, hyperoxia, acids, and endotoxin. Many lung cell types, including epithelial cells and endothelial cells, as well as infiltrating macrophages generate EVs. EVs appear to function by transporting cargo to recipient cells that, in most instances, promote their inflammatory activi...
5 CitationsSource
#1Romain VerseleH-Index: 3
#2Mariangela Corsi (Artois University)H-Index: 1
Last. Pietra CandelaH-Index: 8
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Alzheimer’s disease (AD) is characterized by the abnormal accumulation of amyloid-β (Aβ) peptides in the brain. The pathological process has not yet been clarified, although dysfunctional transport of Aβ across the blood–brain barrier (BBB) appears to be integral to disease development. At present, no effective therapeutic treatment against AD exists, and the adoption of a ketogenic diet (KD) or ketone body (KB) supplements have been investigated as potential new therapeutic approaches. Despite ...
7 CitationsSource
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#1Anatoly P. SobolevH-Index: 24
#2Alessandra Ciampa (Sapienza University of Rome)H-Index: 1
Last. Alessandro PintoH-Index: 16
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A pilot study was carried out on five obese/overweight patients suffering from metabolic syndrome, with the aim to evaluate postprandial effects of high fat/high glycemic load meals enriched by blueberries. Postprandial urine samples were analyzed by 1H-NMR spectroscopy after 2 and 4 h from ingestion to identify potential markers of blueberry intake. Significant decrease of methylamines, acetoacetate, acetone and succinate, known indicators of type 2 diabetes mellitus, were observed after the in...
5 CitationsSource