Shigeyoshi Shimaoka
GlycoproteinImmunohistochemistryTranscriptional regulationLactoferrinAmyotrophic lateral sclerosisEntorhinal cortexCentral nervous systemBrainstemBiologyCell biology
Publications 1
#2Hitomi HamaokaH-Index: 3
Last. Yoichi Kondo (Shiga University of Medical Science)
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Lactoferrin (Lf) is an iron-binding glycoprotein mainly found in exocrine secretions and the secondary granules of neutrophils. In the central nervous system (CNS), expression of the Lf protein has been reported in the lesions of some neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, as well as in the aged brain. Lf is primarily considered an iron chelator, protecting cells from potentially toxic iron or iron-requiring microorganisms...