S. Andrew Hires
University of Southern California
TransgeneFilter (signal processing)Excitatory postsynaptic potentialBiological neural networkBeam diameterG protein-coupled receptorBiomedical engineeringPsychologyNeuroscienceSomatosensory systemElectrophysiologyChemistryMonoamine neurotransmitterMaterials scienceLaser power scalingIn vivoStimulationNeurotransmitterTrigeminal ganglionZebrafishHypothalamusMotor cortexLocus coeruleusNorepinephrinePrimary motor cortexVentral posteromedial nucleusBrakeBarrel cortexPopulationTouch PerceptionSensory inputBehavioral engagementOptogeneticsDopamineLaserMidbrainBiologySensory systemCell biology
Publications 5
#1Jiesi Feng (PKU: Peking University)H-Index: 10
#2Zhang C (CAS: Chinese Academy of Sciences)H-Index: 1
Last. Yulong LiH-Index: 21
view all 19 authors...
Summary Norepinephrine (NE) is a key biogenic monoamine neurotransmitter involved in a wide range of physiological processes. However, its precise dynamics and regulation remain poorly characterized, in part due to limitations of available techniques for measuring NE in vivo. Here, we developed a family of GPCR activation-based NE (GRABNE) sensors with a 230% peak ΔF/F0 response to NE, good photostability, nanomolar-to-micromolar sensitivities, sub-second kinetics, and high specificity. Viral- o...
130 CitationsSource
#1Jinho Kim (SC: University of Southern California)H-Index: 7
#1Jinho KimH-Index: 2
Last. S. Andrew Hires (SC: University of Southern California)H-Index: 2
view all 2 authors...
A new study finds that a major population of output cells in primary motor cortex suppresses movement and behavioral engagement.
3 CitationsSource
#1Jianing Yu (HHMI: Howard Hughes Medical Institute)H-Index: 12
#2Diego A. Gutnisky (HHMI: Howard Hughes Medical Institute)H-Index: 15
Last. Karel Svoboda (HHMI: Howard Hughes Medical Institute)H-Index: 116
view all 4 authors...
During tactile exploration, neural activity related to movement of digits or whiskers is suppressed to facilitate high signal-to-noise ratio encoding of touch. The authors show that in mouse this computation occurs in layer 4 of the barrel cortex and is mediated by fast-spiking interneurons.
66 CitationsSource
#1Samson G. King (SC: University of Southern California)
#2Monica Song (SC: University of Southern California)
Last. S. Andrew Hires (SC: University of Southern California)H-Index: 2
view all 6 authors...
Accurate decision-making requires the precisely timed input of sensory information to yield a functional percept that can inform behavioral choices. Touch perception requires neural activity in primary somatosensory cortex (S1). Here, we determine optimal laser power and shape to optogenetically drive precise spiking activity recorded via electrophysiology in layer IV of mouse S1, for the purpose of biasing sensation and thereby behavior in a multi-whisker two alternative forced-choice task. Our...
#2Ehud AhissarH-Index: 41
Last. Mitra J. Z. HartmannH-Index: 27
view all 19 authors...