Martin S. Judenhofer
University of California, Davis
Imaging phantomSilicon photomultiplierAvalanche photodiodePhotomultiplierOpticsPhysicsPET-CTMolecular imagingPathologyMagnetic resonance imagingArtificial intelligenceMaterials scienceImage resolutionPositron emission tomographyScannerPreclinical imagingNuclear medicineComputer scienceImage qualityResolution (electron density)MedicineDetector
68Publications
28H-index
4,231Citations
Publications 67
Newest
#1Georgia R. Frost (Cornell University)H-Index: 3
#2Valerie A. Longo (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 21
Last. Yue Ming Li (Cornell University)H-Index: 1
view all 10 authors...
Source
#1Georgia R. Frost (Cornell University)H-Index: 3
#2Valerie A. Longo (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 21
Last. Yue Ming Li (Cornell University)H-Index: 1
view all 10 authors...
The emergence of PET probes for amyloid plaques and neurofibrillary tangles, hallmarks of Alzheimer disease (AD), enables monitoring of pathology in AD mouse models. However, small-animal PET imaging is limited by coarse spatial resolution. We have installed a custom-fabricated PET insert into our small-animal MRI instrument and used PET/MRI hybrid imaging to define regions of amyloid vulnerability in 5xFAD mice. We compared fluorine-18 [18F]-Florbetapir uptake in the 5xFAD brain by dedicated sm...
Source
#1Hua Guo (Cornell University)H-Index: 13
#2Harikrishna Kommidi (Cornell University)H-Index: 8
Last. Richard Ting (Cornell University)H-Index: 20
view all 12 authors...
PURPOSE: Knowing the precise flow of cerebrospinal fluid (CSF) is important in the management of multiple neurological diseases. Technology for non-invasively quantifying CSF flow would allow for precise localization of injury and assist in evaluating the viability of certain devices placed in the central nervous system (CNS). METHODS: We describe a near-infrared fluorescent dye for accurately monitoring CSF flow by positron emission tomography (PET) and fluorescence. IR-783, a commercially avai...
Source
#1Xuezhu Zhang (UC Davis: University of California, Davis)H-Index: 15
#2Zhaoheng Xie (UC Davis: University of California, Davis)H-Index: 4
Last. Jinyi Qi (UC Davis: University of California, Davis)H-Index: 53
view all 21 authors...
: Rationale: The world's first 194-cm long total-body PET/CT scanner (uEXPLORER) has been built by the EXPLORER consortium to offer a transformative platform for human molecular imaging in clinical research and healthcare. Its total-body coverage and ultra-high sensitivity provide opportunities for more accurate tracer kinetic analysis in studies of physiology, biochemistry and pharmacology. The objective of this study is to demonstrate the capability of total-body parametric imaging and to quan...
Source
#1P. PengH-Index: 15
Last. Simon R. CherryH-Index: 92
view all 3 authors...
: In most high-resolution PET detector designs, there is an inherent trade-off between spatial resolution and detector efficiency. We have developed and tested a new geometry for the detector module which avoids this trade-off. The module uses a layered structure, in which four crystal slabs are stacked in the depth direction and optically separated by enhanced specular reflector (ESR) film. The scintillation light within each layer is measured by 16 SiPMs located on the four sides of the crysta...
Source
#1Xuezhu Zhang (UC Davis: University of California, Davis)H-Index: 15
#2Zhaoheng Xie (UC Davis: University of California, Davis)H-Index: 4
Last. Jinyi Qi (UC Davis: University of California, Davis)H-Index: 53
view all 18 authors...
456 Introduction: The EXPLORER consortium has developed the world’s first 2-meter long total-body PET scanner (uEXPLORER) to provide a versatile platform for biomedical research and clinical applications. Its total-body coverage and ultra-high sensitivity provide opportunities for more accurate tracer kinetics analysis in studies of new pharmaceuticals, physiology and pathology. In this work, we demonstrate total-body parametric imaging using kernel and direct reconstruction of the EXPLORER data...
#1Yang LvH-Index: 4
#2Xinyu LvH-Index: 1
Last. Ramsey D. Badawi (UC Davis: University of California, Davis)H-Index: 29
view all 12 authors...
: As part of the EXPLORER total-body positron emission tomography (PET) project, we have designed and built a high-resolution, high-sensitivity PET/CT scanner, which is expected to have excellent performance for companion animal whole body and human brain imaging. The PET component has a ring diameter of 52 cm and an axial field of view of 48.3 cm. The detector modules are composed of arrays of lutetium (yttrium) oxyorthosilicate (LYSO) crystals of dimensions 2.76 × 2.76 × 18.1 mm3 coupled to si...
Source
#1Aaron R Selfridge (UC Davis: University of California, Davis)H-Index: 3
#2Simon R. Cherry (UC Davis: University of California, Davis)H-Index: 92
Last. Martin S. Judenhofer (UC Davis: University of California, Davis)H-Index: 28
view all 3 authors...
Preclinical positron emission tomography, combined with magnetic resonance imaging (PET/MRI), is increasingly used as a tool to simultaneously characterize functional processes in vivo. Many emerging preclinical applications, however, are limited by PET detection sensitivity, especially when generating short imaging frames for quantitative studies. One such application is dynamic multifunctional imaging, which probes multiple aspects of a biological process, using relationships between the datas...
Source
#1P. Peng (UC Davis: University of California, Davis)H-Index: 15
#2Martin S. Judenhofer (UC Davis: University of California, Davis)H-Index: 28
Last. Simon R. Cherry (UC Davis: University of California, Davis)H-Index: 92
view all 4 authors...
This paper describes a simulation study of a positron emission tomography (PET) detector module that can reconstruct the kinematics of Compton scattering within the scintillator. We used a layer structure, with which we could recover the positions and energies for the multiple interactions of a gamma ray in the different layers. Using the Compton scattering formalism, the sequence of interactions can be estimated. The true first interaction position extracted in the Compton scattering will help ...
Source
#1Edwin Leung (UC Davis: University of California, Davis)H-Index: 3
#2Martin S. Judenhofer (UC Davis: University of California, Davis)H-Index: 28
Last. Ramsey D. Badawi (UC Davis: University of California, Davis)H-Index: 29
view all 4 authors...
: Coincidence processing in positron emission tomography (PET) is typically done during acquisition of the data. However, on the EXPLORER total-body PET scanner we plan, in addition, to store unpaired single events (i.e. singles) for post-acquisition coincidence processing. A software-based coincidence processor was developed for EXPLORER and its performance was assessed. Our results showed that the performance of the coincidence processor could be significantly impacted by the type of data stor...
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.