Wenwen Si
Therapeutic effectEndosomeGene silencingChromatin immunoprecipitationDopaminergicGene expressionGPX4RNA interferenceChemistryMesenchymal stem cellMoxibustionSorting nexinParkinson's diseaseAtractylodes lanceaSuper-enhancerFTH1Neural degenerationMir 181a 5pChondrogenesisReactive oxygen speciesMedicineBiologyCell biologyPharmacology
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Abstract null null Parkinson's disease (PD) is the second most prevalent neurodegenerative disease worldwide. Recent studies revealed that the ferroptosis pathway is involved in the death process of dopaminergic neurons in PD. The aberrant endosomal sorting pathway, which results in aberrant iron level in eukaryotic cells, may serve a role in the ferroptosis pathway in PD condition. However, its specific molecular mechanisms remained unclear. In the present study, we performed chromatin immunopr...
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#1Zifeng Huang (Guangzhou University of Chinese Medicine)
Last. Meiling ZhuH-Index: 4
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Ferroptosis is associated with neural degeneration of dopaminergic neurons in Parkinson’s disease (PD). However, how to control the level of ferroptosis in PD remains unclear. Clinically, moxibustion has been used to treat PD and has an apparent therapeutic effect on improving the motor symptoms of PD. In the present study, the PD rat model was constructed by two-point stereotactic 6-hydroxydopamine injection. Then, moxibustion was used to treat the PD rats. The expression of glutathione peroxid...
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#1Shanyu YeH-Index: 3
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