Daniela Di Paolo
Istituto Giannina Gaslini
CancerPathologyMolecular biologyNanocarriersLiposomeChemistryApoptosisTherapeutic indexIn vitroImmunologyIn vivoNeuroblastomaDrug deliveryAngiogenesisDoxorubicinCancer researchCell growthMedicineCell cultureBiologyCancer cellPharmacology
47Publications
22H-index
1,265Citations
Publications 46
Newest
#1Daniela Di Paolo (Istituto Giannina Gaslini)H-Index: 22
Last. Cristina BorziH-Index: 8
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Lung cancer is the leading cause of cancer-related death worldwide. Late diagnosis and metastatic dissemination contribute to its low survival rate. Since microRNA (miRNA) deregulation triggers lung carcinogenesis, miRNAs might represent an interesting therapeutic tool for lung cancer management. We identified seven miRNAs, including miR-126-3p and miR-221-3p, that are deregulated in tumours compared with normal tissues in a series of 38 non-small-cell lung cancer patients. A negative correlatio...
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#1Daniela Di Paolo (Istituto Giannina Gaslini)H-Index: 22
#1D. Di Paolo (Istituto Giannina Gaslini)H-Index: 5
Last. Patrizia Perri (Istituto Giannina Gaslini)H-Index: 22
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Neuroblastoma (NB) tumor substantially contributes to childhood cancer mortality. The design of novel drugs targeted to specific molecular alterations becomes mandatory, especially for high-risk patients burdened by chemoresistant relapse. The dysregulated expression of MYCN, ALK, and LIN28B and the diminished levels of miR-34a and let-7b are oncogenic in NB. Due to the ability of miRNA-mimics to recover the tumor suppression functions of miRNAs underexpressed into cancer cells, safe and efficie...
2 CitationsSource
Background: Neuroblastoma (NB) represents the most frequent and aggressive form of extracranial solid tumor of infants. Since the use of targeted therapies is severely limited by the lack of specific receptors, chemotherapy and radiotherapy remain the main treatment choices, which, nevertheless expose high-risk NB patients to unacceptable toxicity and to the development of drug resistance. Nucleolin (NCL), a multifunctional protein involved in both physiological and pathological conditions, is o...
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#1Massimo MoroH-Index: 17
#2Daniela Di Paolo (Istituto Giannina Gaslini)H-Index: 22
Last. Orazio FortunatoH-Index: 11
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Abstract Lung cancer is the leading cause of cancer-related deaths. Late diagnosis and inadequate therapies contribute to poor outcomes. MicroRNAs (miRNAs) are small non-coding RNAs and are involved in lung cancer development. Because miRNAs simultaneously regulate several cancer-related genes, they represent an interesting therapeutic approach for cancer treatment. We have developed Coated Cationic Lipid-nanoparticles entrapping miR-660 (CCL660) and intraperitoneally administered (1.5 mg/Kg) tw...
12 CitationsSource
#1Fabio Pastorino (Istituto Giannina Gaslini)H-Index: 34
#2Chiara Brignole (Istituto Giannina Gaslini)H-Index: 29
Last. Mirco Ponzoni (Istituto Giannina Gaslini)H-Index: 55
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: Neuroblastoma is a rare pediatric cancer characterized by a wide clinical behavior and adverse outcome despite aggressive therapies. New approaches based on targeted drug delivery may improve efficacy and decrease toxicity of cancer therapy. Furthermore, nanotechnology offers additional potential developments for cancer imaging, diagnosis, and treatment. Following these lines, in the past years, innovative therapies based on the use of liposomes loaded with anticancer agents and functionalized...
16 CitationsSource
#1Mirco Ponzoni (Istituto Giannina Gaslini)H-Index: 55
#2Flavio Curnis (UniSR: Vita-Salute San Raffaele University)H-Index: 32
Last. Fabio Pastorino (Istituto Giannina Gaslini)H-Index: 34
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: Targeted delivery of anticancer drugs with nanocarriers can reduce side effects and ameliorate therapeutic efficacy. However, poorly perfused and dysfunctional tumor vessels limit the transport of the payload into solid tumors. The use of tumor-penetrating nanocarriers might enhance tumor uptake and antitumor effects. A peptide containing a tissue-penetrating (TP) consensus motif, capable of recognizing neuropilin-1, is here fused to a neuroblastoma-targeting peptide (pep) previously developed...
10 CitationsSource
#1Mirco Ponzoni (Istituto Giannina Gaslini)H-Index: 55
#2Fabio Pastorino (Istituto Giannina Gaslini)H-Index: 34
Last. Chiara Brignole (Istituto Giannina Gaslini)H-Index: 29
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Macrophages, cells belonging to the innate immune system, present a high plasticity grade, being able to change their phenotype in response to environmental stimuli. They play central roles during development, homeostatic tissue processes, tissue repair, and immunity. Furthermore, it is recognized that macrophages are involved in chronic inflammation and that they play central roles in inflammatory diseases and cancer. Due to their large involvement in the pathogenesis of several types of human ...
49 CitationsSource
#1Mirco PonzoniH-Index: 55
#2Chiara BrignoleH-Index: 29
Last. Fabio PastorinoH-Index: 34
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Background: Anti-cancer drugs-loaded targeted nanocarriers can reduce side-effects and improve therapeutic efficacy in preclinical studies. However, poorly perfused and dysfunctional tumour vessels limit the transport of the payload into the parenchyma of solid tumours. The use of tumour-penetrating nanocarriers might enhance tumour penetration and anti-tumour effects. Methods: A consensus motif, mediator of tissue penetration (TP) was added to a previously characterized neuroblastoma (NB)-targe...
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#1Fabio PastorinoH-Index: 34
#2Chiara BrignoleH-Index: 29
Last. Mirco PonzoniH-Index: 55
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Anticancer drugs loaded into tumor- and vasculature-targeted nanocarriers (NC) can reduce side-effects and improve therapeutic efficacy in pre-clinical studies. However, poorly perfused and dysfunctional tumor vessels and lymphatics limit the transport of the payload into the parenchyma of solid tumors. The use of NC decorated with tumor-penetrating peptides (TPPs) might enhance tumor penetration and antitumor effects. A previously characterized neuroblastoma (NB)-targeting peptide ligand was he...
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#1Müjdat Zeybel (Newcastle University)H-Index: 11
#2Saimir Luli (Newcastle University)H-Index: 8
Last. Derek A. Mann (Newcastle University)H-Index: 71
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The progression of fibrosis in chronic liver disease is dependent upon hepatic stellate cells (HSCs) transdifferentiating to a myofibroblast-like phenotype. This pivotal process is controlled by enzymes that regulate histone methylation and chromatin structure, which may be targets for developing anti-fibrotics. There is limited pre-clinical experimental support for the potential to therapeutically manipulate epigenetic regulators in fibrosis. In order to learn if epigenetic treatment can halt t...
40 CitationsSource